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I love Pure. If you are looking for a lightweight less-intrusive alternative to Bootstrap you should try it, or even to replace part of it.
Can you expound re: "less intrusive?"

My impression of Pure the first time was that it was a bit verbose to do what Bootstrap can do with a col-sm-3 for example. I do like the fraction-based grid though and perhaps verbosity is the price I have to accept to have that.

With the new Get Started page [1], you can change the class names for the grid columns. Here's an example. [2]

[1] http://purecss.io/start/ [2] http://purecss.io/start/?cols=12&prefix=.col-&sm=35.5em&md=4...

Edit: I see you can introduce a full overwrite of the classname.

Beyond that I'd say that Bootstrap includes a lot of what some might call "fluff," but take the CSS alone and I'm struggling to see the "less intrusive" part.

Markup aside, the projects take different approaches: Bootstrap is polished, opinionated defaults that can be overridden, and Pure is a minimal base to extend.
I've been using Pure for a few months now and really like it. Design and organizing CSS aren't my forte and Pure is small, light and easy to extend. I don't use their grid system because I prefer grid mixins[0] over grid classes, but the rest of Pure is really a pleasure to use. It's nice to see the project gaining adoption, back during Pure 0.2 I was worried it might be abandoned.

0 - http://neat.bourbon.io/

Pure core contributor here. Thanks for the kind words fellas. There are still some rough edges in Pure, especially around extending Menus but that's next on our list of things to tackle.
I've used pure on a couple of sites and found it a pleasure to work with. I could probably do a bunch of this stuff manually, but not being a "real" front end guy it's often a surprise battle on different devices. It's nice not having to deal with this. Thanks people who did pure.
I just used Pure for the first time on a small Flask site I'm building and it's been great. Love it as an alternative to bootstrap.

Not wanting to spend a ton of time designing the site (yet), but also wanting to keep it small, made Pure the perfect fit.

After 3 projects in a row on Bootstrap I started using Pure about a month ago, and like the clean, un-opinionated approach. It's been especially useful for learning more about SASS and responsive layout without having to override a bunch of Bootstrap's defaults.