If you had to give a percent figure, what do you believe your mother's chances were of discovering a radical curative treatment for SCC and curing her own cancer?
I notice you've watered down your terminology from "cure" to "improvement on clinical best practice" which are pretty different things in the context of cancer treatment. However, I can respect the switch and I'll treat…
> This virologist did believe that her colleagues were sitting around not rolling out something that would cure her. And because her outcome was so unexpected and unusual it got published as a case study. What you don't…
What doesn't make its way into case studies and HN headlines is all the stories of people who did get access to uncertain treatments and died anyway. Sometimes faster than they would have without the experimental…
This is a big simplification. 1. The interaction between oncolytic virotherapy and host immunity is complex. Consider that oncolytic viruses are also targeted by the immune system. 2. Oncolytic viruses that directly…
> He's not wrong though. It's more of a "not even wrong" statement. It's the kind of useless and reductive analysis poor leaders trot out from a position of personal frustration after failing to surmount the challenges…
"AI assistants are bad" isn't the take. The thing making people feel icky/uncomfortable about Her - and about the 4o demos - is not the idea of Samantha but the idea of Theodore. It's about nerds' idealized AI versions…
This is the thing that is so wild to me. Outside of tech, everyone I encounter in day-to-day life intuitively understands that tech dudes inventing AI voices to flirt with them is not awesome or cool. At this point, I…
> but I don't think she has any rights to voices that merely sound like hers, when they're not being used to fraudently imply that she's involved. IANAL but it's actually not that simple. There are laws and precedents…
There is no point to the article. It's another boring anti-React/Electron screed but with a conspiratorial, junior high polsci bent to it. Having frameworks that allow more devs to do more things means correspondingly…
Quick check of the bio reveals his alternative is Svelte. Weird since the usual Svelte argument is that it's so simple anyone can pick it up and be effective the next day - unlike bloated old React where each team needs…
If medicine is just following a decision tree why would we need LLMs to do it? Computers have been able to follow decision trees for 70 years or something.
> Most places I've worked in the last 6 or so years are obsessed with tooling and add so many lint rules that it's often impossible to merge your pull request if you decide to format your code in a way that violates the…
I recovered, but it took a long time. I don't know about RA. OPs blog post sounds a bit too optimistic for someone living with untreated RA for 3 years.
Yeah, I agree. In some sense, tendons remodel more easily than the brain. Somatic pain disorders can easily ruin someone's life.
Seems like a bizarre omission from the article given the number of tangents and topics covered. My guess is that going down the traditional medicine route lead to him being told there was no organic basis to the pain.…
1. There is a meaningful difference between replacing and assisting. Replacing implies being able to take over the entire function. Technology that assists doctors with one part of their function, or process, can…
It definitely can be. The presence of uncontrolled interruptions is a common complaint in open offices. Individual employees tend to manage this issue with noise cancelling headphones. I've also seen eng managers create…
That's even worse. You're sending out rounds of "Hi's" to multiple people, distracting them to prepare them for a question you might not even ask? Candidly, you sound like an incredibly selfish communicator.
> At the least, its a communication that you are about to ask them something, i.e. check back here in the next minute or so while I type out my question. This is part of what makes it such poor etiquette. You've created…
In theory it's Coase Theorem / Coasean bargaining. But even by economics standards, this theoretical result has little real world applicability.
I don't think the two PoVs are incompatible. Lower tolerance for mess drives people to clean earlier and more proactively. The labor equity issue is a direct consequence of differences in taste. There are lots of group…
> I think there's nothing wrong with seeing your partner struggling with something, talking to them about it and coming up with ideas to help them. There is something wrong here: and that's assuming your partner is the…
Everyone knows that bad actors will continue to behave badly in the face of the law. This isn't the insight you seem to think it is. Really, PG's tweet has little to do with game theory or anything else. It is a…
Agree. How much corporate propaganda are people consuming that legislators are seen as wholly responsible for the bad behavior and malicious compliance actions of corporations? What does it say about the relationship…
If you had to give a percent figure, what do you believe your mother's chances were of discovering a radical curative treatment for SCC and curing her own cancer?
I notice you've watered down your terminology from "cure" to "improvement on clinical best practice" which are pretty different things in the context of cancer treatment. However, I can respect the switch and I'll treat…
> This virologist did believe that her colleagues were sitting around not rolling out something that would cure her. And because her outcome was so unexpected and unusual it got published as a case study. What you don't…
What doesn't make its way into case studies and HN headlines is all the stories of people who did get access to uncertain treatments and died anyway. Sometimes faster than they would have without the experimental…
This is a big simplification. 1. The interaction between oncolytic virotherapy and host immunity is complex. Consider that oncolytic viruses are also targeted by the immune system. 2. Oncolytic viruses that directly…
> He's not wrong though. It's more of a "not even wrong" statement. It's the kind of useless and reductive analysis poor leaders trot out from a position of personal frustration after failing to surmount the challenges…
"AI assistants are bad" isn't the take. The thing making people feel icky/uncomfortable about Her - and about the 4o demos - is not the idea of Samantha but the idea of Theodore. It's about nerds' idealized AI versions…
This is the thing that is so wild to me. Outside of tech, everyone I encounter in day-to-day life intuitively understands that tech dudes inventing AI voices to flirt with them is not awesome or cool. At this point, I…
> but I don't think she has any rights to voices that merely sound like hers, when they're not being used to fraudently imply that she's involved. IANAL but it's actually not that simple. There are laws and precedents…
There is no point to the article. It's another boring anti-React/Electron screed but with a conspiratorial, junior high polsci bent to it. Having frameworks that allow more devs to do more things means correspondingly…
Quick check of the bio reveals his alternative is Svelte. Weird since the usual Svelte argument is that it's so simple anyone can pick it up and be effective the next day - unlike bloated old React where each team needs…
If medicine is just following a decision tree why would we need LLMs to do it? Computers have been able to follow decision trees for 70 years or something.
> Most places I've worked in the last 6 or so years are obsessed with tooling and add so many lint rules that it's often impossible to merge your pull request if you decide to format your code in a way that violates the…
I recovered, but it took a long time. I don't know about RA. OPs blog post sounds a bit too optimistic for someone living with untreated RA for 3 years.
Yeah, I agree. In some sense, tendons remodel more easily than the brain. Somatic pain disorders can easily ruin someone's life.
Seems like a bizarre omission from the article given the number of tangents and topics covered. My guess is that going down the traditional medicine route lead to him being told there was no organic basis to the pain.…
1. There is a meaningful difference between replacing and assisting. Replacing implies being able to take over the entire function. Technology that assists doctors with one part of their function, or process, can…
It definitely can be. The presence of uncontrolled interruptions is a common complaint in open offices. Individual employees tend to manage this issue with noise cancelling headphones. I've also seen eng managers create…
That's even worse. You're sending out rounds of "Hi's" to multiple people, distracting them to prepare them for a question you might not even ask? Candidly, you sound like an incredibly selfish communicator.
> At the least, its a communication that you are about to ask them something, i.e. check back here in the next minute or so while I type out my question. This is part of what makes it such poor etiquette. You've created…
In theory it's Coase Theorem / Coasean bargaining. But even by economics standards, this theoretical result has little real world applicability.
I don't think the two PoVs are incompatible. Lower tolerance for mess drives people to clean earlier and more proactively. The labor equity issue is a direct consequence of differences in taste. There are lots of group…
> I think there's nothing wrong with seeing your partner struggling with something, talking to them about it and coming up with ideas to help them. There is something wrong here: and that's assuming your partner is the…
Everyone knows that bad actors will continue to behave badly in the face of the law. This isn't the insight you seem to think it is. Really, PG's tweet has little to do with game theory or anything else. It is a…
Agree. How much corporate propaganda are people consuming that legislators are seen as wholly responsible for the bad behavior and malicious compliance actions of corporations? What does it say about the relationship…