Yeah seems like related to homeopathic medicine (aromatherapy or essential oils or tinctures)
the study said that the 5 patients with VITT that they looked at had the IGLV3-21 * 02 polymorphism, but it's a fallacy to say that means that you can't get clotting without it
It's a shame that Perceptive Automata shut down.
TRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, and the function of mechanosenstation in…
This paper is the first structure of any odorant receptor-ligand interaction. There's currently no equivalent structure for mammalian odorant receptors to validate the docking theory, but it's likely correct.
Not really. GPCRs amplify signals at each step via their second messenger cascade. These channels form homotetramers whose structure differs greatly from the canonical seven transmembrane domain structure of GPCRs. So…
The Code Breaker by Walter Isaacson is a recent biography of Jennifer Doudna, who won the Nobel Prize for her pioneering work on CRISPR, that you might enjoy
RNA uses uracil/uridine rather than thymine, but uridine is actually quite immunogenic. That's what has prevented people from using mRNA as a therapy until recently, when the founders of BioNTech figured out that they…
A similar article was published in Wired about a month ago: https://www.wired.co.uk/article/mrna-coronavirus-vaccine-pfi...
I have no idea why you think that there were no studies in April. A quick search shows that's wrong. There were initial reports in March, followed by many peer-reviewed studies that started coming out in April, which…
This is an interesting and well-done paper. It is, however, difficult to evaluate these mouse studies because, unlike human ACE2, mouse ACE2 doesn't facilitate SARS-CoV-2 cell entry. Therefore, they had to first deliver…
While you're right they edited the embryos the sentence you quoted is describing a drug (680C91) that they bath-applied to inhibit the TDO enzyme (as a positive control), rather than the CRISPR strategy they used, in…
Normally I agree that press releases way oversell the research, but I don't think that was the case here. Their camelid nanobody approach seems to be a fairly novel idea with some nice benefits over traditional…
That's why I'm in favor of this change in nomenclature.
Excel isn't the program of choice for most scientists and computational biologists, who typically use R, python, or command line tools. However, we often get data from other scientists or reanalyze data from other…
SCN9A variants have certainly been linked to changes in pain sensitivity (in both directions), but where have they been linked to changes in risk for opiate addiction? Even for the variant identified in this paper, the…
Why are people so keen to look for genetic explanations, rather than socioeconomic ones?
Yes, this was noted in the article, which certainly does not proclaim that the CS50 model is the one that all universities and courses should be adopting. "Malan’s contract at Harvard allows him to focus almost…
COVID-19 patients may have neurological symptoms, but that doesn't mean that SARS-CoV-2 directly attacks the CNS. As noted recently, most neurological symptoms associated with COVID-19 can be explained by vasculopathies…
Yeah seems like related to homeopathic medicine (aromatherapy or essential oils or tinctures)
the study said that the 5 patients with VITT that they looked at had the IGLV3-21 * 02 polymorphism, but it's a fallacy to say that means that you can't get clotting without it
It's a shame that Perceptive Automata shut down.
TRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, and the function of mechanosenstation in…
This paper is the first structure of any odorant receptor-ligand interaction. There's currently no equivalent structure for mammalian odorant receptors to validate the docking theory, but it's likely correct.
Not really. GPCRs amplify signals at each step via their second messenger cascade. These channels form homotetramers whose structure differs greatly from the canonical seven transmembrane domain structure of GPCRs. So…
The Code Breaker by Walter Isaacson is a recent biography of Jennifer Doudna, who won the Nobel Prize for her pioneering work on CRISPR, that you might enjoy
RNA uses uracil/uridine rather than thymine, but uridine is actually quite immunogenic. That's what has prevented people from using mRNA as a therapy until recently, when the founders of BioNTech figured out that they…
A similar article was published in Wired about a month ago: https://www.wired.co.uk/article/mrna-coronavirus-vaccine-pfi...
I have no idea why you think that there were no studies in April. A quick search shows that's wrong. There were initial reports in March, followed by many peer-reviewed studies that started coming out in April, which…
This is an interesting and well-done paper. It is, however, difficult to evaluate these mouse studies because, unlike human ACE2, mouse ACE2 doesn't facilitate SARS-CoV-2 cell entry. Therefore, they had to first deliver…
While you're right they edited the embryos the sentence you quoted is describing a drug (680C91) that they bath-applied to inhibit the TDO enzyme (as a positive control), rather than the CRISPR strategy they used, in…
Normally I agree that press releases way oversell the research, but I don't think that was the case here. Their camelid nanobody approach seems to be a fairly novel idea with some nice benefits over traditional…
That's why I'm in favor of this change in nomenclature.
Excel isn't the program of choice for most scientists and computational biologists, who typically use R, python, or command line tools. However, we often get data from other scientists or reanalyze data from other…
SCN9A variants have certainly been linked to changes in pain sensitivity (in both directions), but where have they been linked to changes in risk for opiate addiction? Even for the variant identified in this paper, the…
Why are people so keen to look for genetic explanations, rather than socioeconomic ones?
Yes, this was noted in the article, which certainly does not proclaim that the CS50 model is the one that all universities and courses should be adopting. "Malan’s contract at Harvard allows him to focus almost…
COVID-19 patients may have neurological symptoms, but that doesn't mean that SARS-CoV-2 directly attacks the CNS. As noted recently, most neurological symptoms associated with COVID-19 can be explained by vasculopathies…