there are long regions on the Y chromosome that are very similar to the X chromosome, which would make the analysis difficult: https://en.wikipedia.org/wiki/Pseudoautosomal_region
One minor correction - in step 2 the DNA is not amplified as this would reduce the fragment length and also lose the methylation information
The "ultra long" nanopore reads used in this study are often greater than 100kbp in length and occasionally up to 1Mbp
the distinction is important here because this subthread started from the suggestion that there are multiple strains circulating, with different virulence. The fact there are multiple lineages is a natural consequence…
yes: https://www.sciencemag.org/news/2020/03/mutations-can-reveal...
"Is here. This not a joke. We can wonder about the license though. Maybe we should ask the walking product of this source: Craig Venter." The reference build of the human genome (provided here by Ensembl) is almost…
This is the most important statement in the paper.
It is common to compare traits in monozygotic vs dizygotic twins to help control for shared environments.
Also a great example of the system working as intended. A group publishes a dubious study with potentially important implications and people queue up to refute it, correcting the scientific record.
there are long regions on the Y chromosome that are very similar to the X chromosome, which would make the analysis difficult: https://en.wikipedia.org/wiki/Pseudoautosomal_region
One minor correction - in step 2 the DNA is not amplified as this would reduce the fragment length and also lose the methylation information
The "ultra long" nanopore reads used in this study are often greater than 100kbp in length and occasionally up to 1Mbp
the distinction is important here because this subthread started from the suggestion that there are multiple strains circulating, with different virulence. The fact there are multiple lineages is a natural consequence…
yes: https://www.sciencemag.org/news/2020/03/mutations-can-reveal...
"Is here. This not a joke. We can wonder about the license though. Maybe we should ask the walking product of this source: Craig Venter." The reference build of the human genome (provided here by Ensembl) is almost…
This is the most important statement in the paper.
It is common to compare traits in monozygotic vs dizygotic twins to help control for shared environments.
Also a great example of the system working as intended. A group publishes a dubious study with potentially important implications and people queue up to refute it, correcting the scientific record.