To push back a little, isn't there causality inherently in these sequence-to-function models, in the sense that causality must proceed in the direction of genetics -> predicted molecular function? And the genetic…
There are existing frameworks for integrating functional and statistical fine mapping methods (e.g. polyfun + susie/finemap). They use annotation overlaps like epigenetic or conservation tracks but can be extended to…
Such an advantage that is rare and across such long time scales would be so small on average that it would be effectively neutral. Natural selection can only really act on fitness advantages greater than on the order of…
Plenty of simple models in biology that don't model the underlying details provide profoundly generalizable insights across scales. The percolation threshold model explains phase transition behavior from the…
To push back a little, isn't there causality inherently in these sequence-to-function models, in the sense that causality must proceed in the direction of genetics -> predicted molecular function? And the genetic…
There are existing frameworks for integrating functional and statistical fine mapping methods (e.g. polyfun + susie/finemap). They use annotation overlaps like epigenetic or conservation tracks but can be extended to…
Such an advantage that is rare and across such long time scales would be so small on average that it would be effectively neutral. Natural selection can only really act on fitness advantages greater than on the order of…
Plenty of simple models in biology that don't model the underlying details provide profoundly generalizable insights across scales. The percolation threshold model explains phase transition behavior from the…