In addition to what others have written (mainly, loss of tumor antigen target CD19) the antigen receptor (part of the CAR) can be recognized as foreign (FMC63 on human CD19 targeting CARs is mouse origin) and the body…
Tumor vaccines are not at all equivalent to CAR-T. CAR-T involves genetically reprogramming T cells with information encoding a specific signal to find cancer, recognize it like a lock and key, and then destroy it.…
In addition to what others have written (mainly, loss of tumor antigen target CD19) the antigen receptor (part of the CAR) can be recognized as foreign (FMC63 on human CD19 targeting CARs is mouse origin) and the body…
Tumor vaccines are not at all equivalent to CAR-T. CAR-T involves genetically reprogramming T cells with information encoding a specific signal to find cancer, recognize it like a lock and key, and then destroy it.…