> It's possible that it's very difficult to engineer a virus that can do better than anything nature has come up with As someone finishing a PhD in computer-aided drug discovery, this seems to be the situation in a lot…
> Coevolution was part of it, but the actual "breakthrough" in their paper was the use metagenome sequences for protein structure prediction Ah -- I hadn't read into the metagenomics aspect. That is quite substantial.…
I was surprised to see the "breakthrough" in this article. The idea to use correlated mutations to identify contacting residues has been around since the 90's [1](if not earlier), but it seems like it's just now getting…
> It's possible that it's very difficult to engineer a virus that can do better than anything nature has come up with As someone finishing a PhD in computer-aided drug discovery, this seems to be the situation in a lot…
> Coevolution was part of it, but the actual "breakthrough" in their paper was the use metagenome sequences for protein structure prediction Ah -- I hadn't read into the metagenomics aspect. That is quite substantial.…
I was surprised to see the "breakthrough" in this article. The idea to use correlated mutations to identify contacting residues has been around since the 90's [1](if not earlier), but it seems like it's just now getting…