Well, confusingly, the last picture on the blogpost look (to my untrained eye) to be tetrapods. Those are 'tetrahedral' (ish) shapes. In contrast, the https://en.wikipedia.org/wiki/Dolos (plural 'Dolosse') are two…
Interesting point - usually people approach the question "who draws the tiger" from the other end. As in, the assumption is (not unreasonably!) the genAI is doing all the work and the AI 'artist' is doing nothing. Of…
Of course, now the question the boy in the article asked - "where does the Tiger come from?" - could be answered with "the prompt". The arguments today are whether a prompt like "draw a Tiger" are the same somehow to…
I see that I was unclear - I did not mean "the law goes along with this, and I don't know why?" I meant "I do not understand why Sov. Cit. would believe that the law would agree to these ideas".
A very clear example of this is the 'Sovereign Citizen', who have bizarre beliefs around how to interact with courts. As far as I understand it, there are some 'cheat codes' people believe (incorrectly) are effective in…
I suspect Sandi Toksvig, one of the hosts of QI. One of the 'success' messages is "quite interestng!". No offence mean to anyone, but the whole exercise feels very QI : superficial 'understanding' of a large range of…
That's actually a feature that washing machines have had for a while - "generative washing" - it is where the extra odd socks come from.
I recently bought the book 'Watch Repair for Beginners' for reference (a project I slightly unwisely agreed to do). It has some great diagrams, but obviously nothing on these interactive animations (er, naturally, since…
I meant metallocenes in general: https://en.wikipedia.org/wiki/Metallocene A metal atom sandwiched between two Cp rings. You _can_ model this as 5 single bonds between each atom of a ring (so 10 total C-M bonds), or you…
There is a lot of graph theory in Chemistry - modelling chemicals as (vertex/edge coloured) graphs, reaction networks, etc. Of course some molecules (eg aromatic systems, like ferrocene) are not naturally representable…
You got me. Usually I read them. edit: Huh. Actually not a bad read. It even mentions ' On Growth and Form' which is interesting, if outdated. There are more modern texts like 'Shapes', 'Flow', and 'Branches' by Philip…
Surface area to volume ratio?
A very reasonable question, that I don't have an immediate concrete answer to! Apparently I upvoted this question in the past (found it by searching for an answer - no AI, like the good old days)…
That would be difficult - a metabolic map is a diagram showing the known reactions. At any point in time, only a subset of these will be active. Like a road map - at midnight, only some roads will have traffic. I think…
> add too numbers Did you do this on purpose to anger both Mathematicians and keen spellers?
Heh, on my watchlist - ""The Unreasonable Effectiveness of Group Theory" - https://www.youtube.com/watch?v=1XsXRUsNEC4
Yes, I was watching a video about that the other day - the 'dark proteome' or the 'ghost proteome' or similar.
A random sequence may not fold at all! I seem to remember a paper that tried this, creating a bunch of random proteins, and checking how much structure they had - I think they were helical bundles, but don't quote me.…
I see. I meant 'energetically accessible', but you mean more like 'affordably accessible' (in the sense that the molecular toolkit of a cell is what can 'afford' certain structures, due to chaperones available and so…
This is about folds, not amino acids - even if you used a larger alphabet of residues, I somehow doubt that you would get many more folds. Thinking more about the question of protein _length_ - I'm also not convinced…
I understood it as metaphor - just that evolutionarily distant sequences can adopt the same (or very similar) folds because there are only a limited number of stable, accessible folds that are possible.
They found "several thousand" novel folds? I had remembered that there were around 1000: https://pmc.ncbi.nlm.nih.gov/articles/PMC7072414/ Oh ok, I misremembered: "This review has focused only on small fragments of fold…
Ah FeMo-co! One of the cooler cofactors - iron-sulfur cluster, plus a molybdenum, and finally a bridging carbon (https://en.wikipedia.org/wiki/FeMoco) So yes, I can understand why it took so long to calculate the…
Hate to agree, but it is true. For a while, I think, the main sequencing framework was in perl (Bioperl). Not sure what was best for structures - possibly Biojava? It is very tempting, though - 'just' make a nice, clean…
DNA is one-dimensional aperiodicity, which is ... fairly common. This sentence is one-dimensionally aperiodic! Most biological structures are amorphous in some way, rather than strictly aperiodic. There are structures…
Well, confusingly, the last picture on the blogpost look (to my untrained eye) to be tetrapods. Those are 'tetrahedral' (ish) shapes. In contrast, the https://en.wikipedia.org/wiki/Dolos (plural 'Dolosse') are two…
Interesting point - usually people approach the question "who draws the tiger" from the other end. As in, the assumption is (not unreasonably!) the genAI is doing all the work and the AI 'artist' is doing nothing. Of…
Of course, now the question the boy in the article asked - "where does the Tiger come from?" - could be answered with "the prompt". The arguments today are whether a prompt like "draw a Tiger" are the same somehow to…
I see that I was unclear - I did not mean "the law goes along with this, and I don't know why?" I meant "I do not understand why Sov. Cit. would believe that the law would agree to these ideas".
A very clear example of this is the 'Sovereign Citizen', who have bizarre beliefs around how to interact with courts. As far as I understand it, there are some 'cheat codes' people believe (incorrectly) are effective in…
I suspect Sandi Toksvig, one of the hosts of QI. One of the 'success' messages is "quite interestng!". No offence mean to anyone, but the whole exercise feels very QI : superficial 'understanding' of a large range of…
That's actually a feature that washing machines have had for a while - "generative washing" - it is where the extra odd socks come from.
I recently bought the book 'Watch Repair for Beginners' for reference (a project I slightly unwisely agreed to do). It has some great diagrams, but obviously nothing on these interactive animations (er, naturally, since…
I meant metallocenes in general: https://en.wikipedia.org/wiki/Metallocene A metal atom sandwiched between two Cp rings. You _can_ model this as 5 single bonds between each atom of a ring (so 10 total C-M bonds), or you…
There is a lot of graph theory in Chemistry - modelling chemicals as (vertex/edge coloured) graphs, reaction networks, etc. Of course some molecules (eg aromatic systems, like ferrocene) are not naturally representable…
You got me. Usually I read them. edit: Huh. Actually not a bad read. It even mentions ' On Growth and Form' which is interesting, if outdated. There are more modern texts like 'Shapes', 'Flow', and 'Branches' by Philip…
Surface area to volume ratio?
A very reasonable question, that I don't have an immediate concrete answer to! Apparently I upvoted this question in the past (found it by searching for an answer - no AI, like the good old days)…
That would be difficult - a metabolic map is a diagram showing the known reactions. At any point in time, only a subset of these will be active. Like a road map - at midnight, only some roads will have traffic. I think…
> add too numbers Did you do this on purpose to anger both Mathematicians and keen spellers?
Heh, on my watchlist - ""The Unreasonable Effectiveness of Group Theory" - https://www.youtube.com/watch?v=1XsXRUsNEC4
Yes, I was watching a video about that the other day - the 'dark proteome' or the 'ghost proteome' or similar.
A random sequence may not fold at all! I seem to remember a paper that tried this, creating a bunch of random proteins, and checking how much structure they had - I think they were helical bundles, but don't quote me.…
I see. I meant 'energetically accessible', but you mean more like 'affordably accessible' (in the sense that the molecular toolkit of a cell is what can 'afford' certain structures, due to chaperones available and so…
This is about folds, not amino acids - even if you used a larger alphabet of residues, I somehow doubt that you would get many more folds. Thinking more about the question of protein _length_ - I'm also not convinced…
I understood it as metaphor - just that evolutionarily distant sequences can adopt the same (or very similar) folds because there are only a limited number of stable, accessible folds that are possible.
They found "several thousand" novel folds? I had remembered that there were around 1000: https://pmc.ncbi.nlm.nih.gov/articles/PMC7072414/ Oh ok, I misremembered: "This review has focused only on small fragments of fold…
Ah FeMo-co! One of the cooler cofactors - iron-sulfur cluster, plus a molybdenum, and finally a bridging carbon (https://en.wikipedia.org/wiki/FeMoco) So yes, I can understand why it took so long to calculate the…
Hate to agree, but it is true. For a while, I think, the main sequencing framework was in perl (Bioperl). Not sure what was best for structures - possibly Biojava? It is very tempting, though - 'just' make a nice, clean…
DNA is one-dimensional aperiodicity, which is ... fairly common. This sentence is one-dimensionally aperiodic! Most biological structures are amorphous in some way, rather than strictly aperiodic. There are structures…