I'm honestly not familiar with "deep mutational scanning." Can you share a link? I'm first author on papers related to the structural biology of coevolution and I competed in CASP about a decade ago, but I haven't kept…
It doesn't matter so much how they perform the feature extraction, so much as what their inputs to the feature extraction are. This model requires a collection of wild-type proteins in an accurate MSA. Producing an…
The method relies on multiple-sequence-alignment (MSA) of homologous proteins. This cannot fold arbitrary proteins, only biologically relevant ones that have high quality MSAs available. It's also worth pointing out…
I'm honestly not familiar with "deep mutational scanning." Can you share a link? I'm first author on papers related to the structural biology of coevolution and I competed in CASP about a decade ago, but I haven't kept…
It doesn't matter so much how they perform the feature extraction, so much as what their inputs to the feature extraction are. This model requires a collection of wild-type proteins in an accurate MSA. Producing an…
The method relies on multiple-sequence-alignment (MSA) of homologous proteins. This cannot fold arbitrary proteins, only biologically relevant ones that have high quality MSAs available. It's also worth pointing out…