Yes, that is exactly what I meant! Here’s an experiment to try: Frances Arnold got a nobel prize for work related to directed evolution. However, we know evolution is limited by the tools available to it as you mention.…
This approach is pretty much like the TED approach from a few years back. As far as I remember there wasn’t a ridiculous amount of fold diversity there either. It turns out evolution isn’t averse to a bit of liberal…
This looks very cool. Does the window picker for multi-window apps work with the pinning? So if I have a safari windows I want to have associated with a profile, and the option-tab will ignore all the other windows? It…
Even better, don’t ban it, but require companies to do age verification (above a certain age?) before displaying advertising. You get two wins in one: make the child market less attractive for algorithmic feeds, and you…
It is a huge worry for me that unless we decouple the publishing “system” from the career pathways (i.e., rewards), we are going to lose access to both the careers (to robot-weilding bullshitters) and even worse, the…
For prosterity, the original report on the pilot program with the checklist including introducing names of participants (doi 10.1056/NEJMsa0810119). Possibly popularised by Atul Gawande “The Checklist Manifesto”.…
That is really insightful regarding the ritual improving outcomes through better communication - something I see reflected in many meetings I turn up to now which involve an introduction round between participants, and…
This is great - now I can get the authentic conference experience of a disengaged speaker reading out the slides in a monotone, without all the hassle of international travel and scheduling. In all seriousness, there…
I was ruminating about how Atproto would be great for re-thinking the peer review system for scientific journals. Imagine a world where a preprint is “published” onto the social web, from which you could aggregate…
Arc institute probably.
It is a real shame that peer review reports were only first published relatively recently. These would have provided valuable training information as to what peer review performs. Unfortunately now, I fully expect the…
Not my subject area, but at least one other group looked at ABCA1, and judging from this abstract, it has been linked via GWAS already, and furthermore concludes it doesn’t play a role (I haven’t looked at the data…
I guess that whatever recognises the enhancers must be conserved ish in mice for us to be able to drop this region into the mouse genome. That might be interesting alone apart from the functions of the frizzleds. Always…
My innate immune system is here for chewing gum and binding viral glycans, and I’m all out of specific lectins. Looks like this works by apparently binding complex N-glycans on the viral envelope. I can’t imagine this…
This is pretty interesting, also that they get it down to the amount of mannan in the fungal cell walls being somehow related to the β cell amounts. There's probably a nice project in here to figure out what the…
Ancient medicine solves that problem https://news.ycombinator.com/item?id=43196488
I think what you mean is the MUC1-20 (ish, numbering is a bit sloppy but hopefully we can clean it up in near future) genes encode for mucins, that are synthesised on a ribosome, threaded into ER, shuffled off into the…
Mucins aren't enzymes (as far as we know!), and the gut mucins are a bit different from those found on the endothelium, largely because they have different functions. The gut (and generally mucous epithelial) mucus is…
Yes, something along these lines, and maybe the other pathways as the most interesting possibility. I don’t know if there any reports of sTn in older mice, but that would be pretty wild.
Catflap is a surprisingly apt analogy. In this case it is an endocytosis receptor, that selects cargo for uptake. Differs from virus to virus of course, but I could see changes in the sugars on these proteins altering…
Fun fact: The AAVR (AAV receptor) is itself a glycoprotein (carrying the precise type of glycosylation they are trying to repair with the “gene therapy”). Haven’t read up what replacement gene dose ended up being, but…
We don’t know is the answer. However, if you were coral, then I would suggest increasing the amount of symbiotic algae, which stimulates mucin secretion (probably a nutrient boost). A brain normally doesn’t receive…
This area is very much in my wheelhouse (both the biosynthetic process, and functions of mucins). They’re a pretty interesting biomolecule, present in all animals (slightly different molecules in other branches of…
First question I have is what kind of nutrient base conditions can we expect to start from? Should it be like Earth, or somewhere a bit more resource constrained (and how would it be constrained)? I’d like to imagine…
Colour me unsurprised - even not knowing data leakage had occurred, the hypothesis was underwhelming, as I mentioned in a comment on an earlier discussion. I sometimes despair for the state of thinking in science these…
Yes, that is exactly what I meant! Here’s an experiment to try: Frances Arnold got a nobel prize for work related to directed evolution. However, we know evolution is limited by the tools available to it as you mention.…
This approach is pretty much like the TED approach from a few years back. As far as I remember there wasn’t a ridiculous amount of fold diversity there either. It turns out evolution isn’t averse to a bit of liberal…
This looks very cool. Does the window picker for multi-window apps work with the pinning? So if I have a safari windows I want to have associated with a profile, and the option-tab will ignore all the other windows? It…
Even better, don’t ban it, but require companies to do age verification (above a certain age?) before displaying advertising. You get two wins in one: make the child market less attractive for algorithmic feeds, and you…
It is a huge worry for me that unless we decouple the publishing “system” from the career pathways (i.e., rewards), we are going to lose access to both the careers (to robot-weilding bullshitters) and even worse, the…
For prosterity, the original report on the pilot program with the checklist including introducing names of participants (doi 10.1056/NEJMsa0810119). Possibly popularised by Atul Gawande “The Checklist Manifesto”.…
That is really insightful regarding the ritual improving outcomes through better communication - something I see reflected in many meetings I turn up to now which involve an introduction round between participants, and…
This is great - now I can get the authentic conference experience of a disengaged speaker reading out the slides in a monotone, without all the hassle of international travel and scheduling. In all seriousness, there…
I was ruminating about how Atproto would be great for re-thinking the peer review system for scientific journals. Imagine a world where a preprint is “published” onto the social web, from which you could aggregate…
Arc institute probably.
It is a real shame that peer review reports were only first published relatively recently. These would have provided valuable training information as to what peer review performs. Unfortunately now, I fully expect the…
Not my subject area, but at least one other group looked at ABCA1, and judging from this abstract, it has been linked via GWAS already, and furthermore concludes it doesn’t play a role (I haven’t looked at the data…
I guess that whatever recognises the enhancers must be conserved ish in mice for us to be able to drop this region into the mouse genome. That might be interesting alone apart from the functions of the frizzleds. Always…
My innate immune system is here for chewing gum and binding viral glycans, and I’m all out of specific lectins. Looks like this works by apparently binding complex N-glycans on the viral envelope. I can’t imagine this…
This is pretty interesting, also that they get it down to the amount of mannan in the fungal cell walls being somehow related to the β cell amounts. There's probably a nice project in here to figure out what the…
Ancient medicine solves that problem https://news.ycombinator.com/item?id=43196488
I think what you mean is the MUC1-20 (ish, numbering is a bit sloppy but hopefully we can clean it up in near future) genes encode for mucins, that are synthesised on a ribosome, threaded into ER, shuffled off into the…
Mucins aren't enzymes (as far as we know!), and the gut mucins are a bit different from those found on the endothelium, largely because they have different functions. The gut (and generally mucous epithelial) mucus is…
Yes, something along these lines, and maybe the other pathways as the most interesting possibility. I don’t know if there any reports of sTn in older mice, but that would be pretty wild.
Catflap is a surprisingly apt analogy. In this case it is an endocytosis receptor, that selects cargo for uptake. Differs from virus to virus of course, but I could see changes in the sugars on these proteins altering…
Fun fact: The AAVR (AAV receptor) is itself a glycoprotein (carrying the precise type of glycosylation they are trying to repair with the “gene therapy”). Haven’t read up what replacement gene dose ended up being, but…
We don’t know is the answer. However, if you were coral, then I would suggest increasing the amount of symbiotic algae, which stimulates mucin secretion (probably a nutrient boost). A brain normally doesn’t receive…
This area is very much in my wheelhouse (both the biosynthetic process, and functions of mucins). They’re a pretty interesting biomolecule, present in all animals (slightly different molecules in other branches of…
First question I have is what kind of nutrient base conditions can we expect to start from? Should it be like Earth, or somewhere a bit more resource constrained (and how would it be constrained)? I’d like to imagine…
Colour me unsurprised - even not knowing data leakage had occurred, the hypothesis was underwhelming, as I mentioned in a comment on an earlier discussion. I sometimes despair for the state of thinking in science these…