The cost of manufacturing drugs is not where pharma makes it’s profits. Look at the margins for competitive generic drugs and over the counter medicine. Margins are tight. Pharma makes bank on drugs that are patent…
Hearing people talk about the “information superhighway” was exceptionally tedious. The biggest difference to me is the tone. The dot-com era was brimming with optimism and enthusiasm. People were getting rich (on…
Drug design is hard because it’s a system problem not a molecule-protein interaction problem. At one point the gold standard for generating leads was using combinatorial chemistry to experimentally screen through…
It’s marketing, but in a global good will sense of “look how much OpenAI cares about secure open source.” This works for established profitable brands that want to build / maintain a good public image. This isn’t the…
I agree it’s not great, and finding an MCU that does this well is challenging. But that may just become a hardware design constraint going forward. It’s not clear to me what else one can do to protect this kind of IP if…
One solution is to encrypt the firmware and keep the decryption keys on the hardware side, preferably in something that’s tamper resistant. It’s not ideal. It has serious drawbacks. It makes development and updates a…
> Software engineers are getting laid off because of advancements made by AI. This is said by a lot of CEOs trying to make layoffs look good, but I haven’t seen anything that suggests that it’s true. > Yet I see far…
> Assume the model which initiates the worm is a high powered model. The disconnect here is that highly powered models have billions or trillions of parameters and have compute requirements that scale with the parameter…
> Instead of infrastructure being more easily shared with the collective, or valued enough to build a business, now companies can tailor even major infrastructure to their own needs, and avoid all that coordination.…
> I hypothesize that the kind of reader who wants a physical copy of a book is much happier to get a hardcover. Nope. I vastly prefer paperback. I don’t like ebooks much, and hardcover books are too large, too heavy,…
Most good scientists work hard to prove results to themselves before going public. Peer review is then done _in private_ before publication as a check on quality and significance. Retracting a paper is pretty…
They only withdrew it after someone pointed out that it was a flawed paper. In one case by asking Astra to review it. Not exactly encouraging that they did their homework before publishing results.
I think the general argument is “if you can’t bother writing a blog post, then why should I read it? Which seems like a pretty good argument to me, given the amount of slip out there and how increasingly performative…
Long before ChatGPT I would occasionally see a LinkedIn post and get suckered into clicking on it. A waste of time. Every. Single. Time. It wasn’t quite as needlessly performative. But it’s never been good.
In a trivial sense, arrays are hash tables with a hash function of the identity f(x)=x. It’s just not particularly common (or helpful) to view them that way.
This is pretty typical product positioning. You want to sell to both high-end and low-end users, so you offer products at a few price points. Then it turns out that that middle is a much better fit for most users. So…
It might be, but ... there are a lot of us who've seen this happen time and time again. You have some startup, the founder is either young or doesn't want to do the CEO stuff. Things kind of eek along until the founder…
> Most interactive tech on Star Trek is like this - from phasers to consoles to communicators to voice interactions with the ship's computer. Almost like the Star Trek mechanisms can infer perfect intent. Like there’s a…
Some fraction of applications that don’t really fit are submitted by people trying to keep their unemployment benefits. You have to keep applying to continue to qualify, but the jobs don’t have to be a perfect fit.…
> It's never the case that someone misunderstood what scientist wrote. This is wrong. Reporters frequently don’t understand the science or the nuance in the science. Reporting and science are two very different…
In simplest terms: if you don’t tell the kernel that you’re waiting, the scheduler assumes you aren’t and will wake you up and let you spin, to the detriment of other threads that aren’t waiting. If the OS knows that a…
> from a business perspective AI is a legit threat to Amazon because headless Amazon makes it more difficult for Amazon to sell ads, which is a large part of their revenue. The dystopian part of me suspects that this is…
There are a lot of companies and academic institutions working on genomics. Most don’t do self promotion at the scale that Google does. And most aren’t on the HN radar.
It’s a very common experience that people in the physics-adjacent sciences have. It’s so common that there’s an xkcd about it: https://xkcd.com/793/
My job hasn’t completely changed. It’s changed, but fundamentally I solve problems. Sometimes LLMs help me do that now. The job market sucks, but there are so many confounding factors: pandemic over hiring, the loss of…
The cost of manufacturing drugs is not where pharma makes it’s profits. Look at the margins for competitive generic drugs and over the counter medicine. Margins are tight. Pharma makes bank on drugs that are patent…
Hearing people talk about the “information superhighway” was exceptionally tedious. The biggest difference to me is the tone. The dot-com era was brimming with optimism and enthusiasm. People were getting rich (on…
Drug design is hard because it’s a system problem not a molecule-protein interaction problem. At one point the gold standard for generating leads was using combinatorial chemistry to experimentally screen through…
It’s marketing, but in a global good will sense of “look how much OpenAI cares about secure open source.” This works for established profitable brands that want to build / maintain a good public image. This isn’t the…
I agree it’s not great, and finding an MCU that does this well is challenging. But that may just become a hardware design constraint going forward. It’s not clear to me what else one can do to protect this kind of IP if…
One solution is to encrypt the firmware and keep the decryption keys on the hardware side, preferably in something that’s tamper resistant. It’s not ideal. It has serious drawbacks. It makes development and updates a…
> Software engineers are getting laid off because of advancements made by AI. This is said by a lot of CEOs trying to make layoffs look good, but I haven’t seen anything that suggests that it’s true. > Yet I see far…
> Assume the model which initiates the worm is a high powered model. The disconnect here is that highly powered models have billions or trillions of parameters and have compute requirements that scale with the parameter…
> Instead of infrastructure being more easily shared with the collective, or valued enough to build a business, now companies can tailor even major infrastructure to their own needs, and avoid all that coordination.…
> I hypothesize that the kind of reader who wants a physical copy of a book is much happier to get a hardcover. Nope. I vastly prefer paperback. I don’t like ebooks much, and hardcover books are too large, too heavy,…
Most good scientists work hard to prove results to themselves before going public. Peer review is then done _in private_ before publication as a check on quality and significance. Retracting a paper is pretty…
They only withdrew it after someone pointed out that it was a flawed paper. In one case by asking Astra to review it. Not exactly encouraging that they did their homework before publishing results.
I think the general argument is “if you can’t bother writing a blog post, then why should I read it? Which seems like a pretty good argument to me, given the amount of slip out there and how increasingly performative…
Long before ChatGPT I would occasionally see a LinkedIn post and get suckered into clicking on it. A waste of time. Every. Single. Time. It wasn’t quite as needlessly performative. But it’s never been good.
In a trivial sense, arrays are hash tables with a hash function of the identity f(x)=x. It’s just not particularly common (or helpful) to view them that way.
This is pretty typical product positioning. You want to sell to both high-end and low-end users, so you offer products at a few price points. Then it turns out that that middle is a much better fit for most users. So…
It might be, but ... there are a lot of us who've seen this happen time and time again. You have some startup, the founder is either young or doesn't want to do the CEO stuff. Things kind of eek along until the founder…
> Most interactive tech on Star Trek is like this - from phasers to consoles to communicators to voice interactions with the ship's computer. Almost like the Star Trek mechanisms can infer perfect intent. Like there’s a…
Some fraction of applications that don’t really fit are submitted by people trying to keep their unemployment benefits. You have to keep applying to continue to qualify, but the jobs don’t have to be a perfect fit.…
> It's never the case that someone misunderstood what scientist wrote. This is wrong. Reporters frequently don’t understand the science or the nuance in the science. Reporting and science are two very different…
In simplest terms: if you don’t tell the kernel that you’re waiting, the scheduler assumes you aren’t and will wake you up and let you spin, to the detriment of other threads that aren’t waiting. If the OS knows that a…
> from a business perspective AI is a legit threat to Amazon because headless Amazon makes it more difficult for Amazon to sell ads, which is a large part of their revenue. The dystopian part of me suspects that this is…
There are a lot of companies and academic institutions working on genomics. Most don’t do self promotion at the scale that Google does. And most aren’t on the HN radar.
It’s a very common experience that people in the physics-adjacent sciences have. It’s so common that there’s an xkcd about it: https://xkcd.com/793/
My job hasn’t completely changed. It’s changed, but fundamentally I solve problems. Sometimes LLMs help me do that now. The job market sucks, but there are so many confounding factors: pandemic over hiring, the loss of…