impressive to me, but sadly i feel a little misleading since this is only the data-science part of life sciences. every few weeks though i test claude and chatgpt on their scientific reasoning and it has definitely…
i'm very late but i just wanted to give you kudos for a succinct yet spot-on comment on the state of funding. you captured everything i've been trying to put into words and failing miserably at.
the recent drama about science funding to me highlights one of the main problems with our grant-based distribution system: which is that it is unsurprisingly very frail to fast-moving changes in government and society…
The stem cell field is also quirky. IMO it is one of the most cutthroat, competitive, ruthless fields of life sciences that is new enough in history to still have a bunch of pioneers fighting to be the figurative…
> They're in a sticky spot where their most successful customer is one that they will never see another dime from, and there's not really a way around it. naive question: why has no one made an app with the reverse…
sadly no, this is not a thing and it's critically needed. top on my list of things to do if i were a billionaire: launch an institute for the sole purpose of reproducing other's findings.
the problem is two-fold in my opinion. firstly, there are basically no legal repercussions for scientific misconduct (e.g. falsifying data, fake images, etc.). most individuals who are caught doing this get either 1) a…
sadly it looks like seanhunter was correct, shame.
every few months i like to ask chatgpt to do the "thinking" part of my job (scientist) and see how the responses stack up. at the beginning 2022 it was useless because the output was garbage (hallucinations and fake…
i am very glad to see others (presumably non-scientists) in this thread dunking on the false paradigm that "peer review = true". anyone who peddles this notion is naive or a moron. while the author is correct that the…
some added context (both my parents are/were in the Foreign Service): your location is assigned based on a competitive bidding system where you select from a list of cities to do your next tour. some countries/cities…
the small molecule is SW033291, papers are required to publish this specific detail but second order news sources tend to avoid the technical details.
at the dissolution and decentralization of empires feudalism in it's many forms historically seems to be the most common outcome. i would say that we firmly live in the American Empire with techno-feudalistic…
my own institution launched an internal investigation into a professor who i know for a fact committed fraud and was "unable to prove intentional wrongdoing". academic institutions have taken the "this never happens…
the greatest travesty of modern science is that fraud is not illegal. in every other industry that i can imagine, purposely committing fraud has been made illegal. this is not the case in modern science, and in my…
I think about this quite a lot. I’ve come to the conclusion that in the past acting with integrity was rewarded and lacking integrity was punished. In 2025 it seems integrity is meaningless, “winning” is all that…
chatgpt making targeted "recommendations" (read ads) is a nightmare. especially if it's subtle and not disclosed.
My portfolio was +94% in 2024 and +52% in the past 6 months (I took a massive haircut thanks to April's tariff saga and by having biblical levels of greed...lesson learned). How do I declare for the inaugural Hedge Fund…
yup, anecdotally the majority of postdocs these days are internationals who are willing to work 60+ hour weeks on $50k a year, for the infinitesimal chance to land a R1 tenure-track faculty position. americans have no…
Painkillers like ibuprofen are NSAIDs which inhibit the enzyme COX1/2, reducing prostaglandin production. Prostaglandins are an inflammatory hormone that do a variety of things, but specifically PGE2 plays a role in…
I've always thought of these VC fueled expeditions to nowhere as the opposite. Wealth transfer from the owning class to the middle class seeing as a lot of these ventures crash and burn with nothing to show for it.…
I’m sorry who is who in this analogy. Because if internet/tech is the gun then the clear solution is “not giving your children guns”. Bad modern parents just give their kids an iPad.
On the topic of hammers: "if you don't hold the hammer at exactly 2.6cm from the end of the handle and strike the nail with 6N of force at an angle of 58 degrees then of course you won't get a good nail strike into the…
Just like AI seems like it's being used as a convenient scapegoat for the layoffs and trimming following the end of ZIRP, now we see it also being used to blame for the failures of our modern education system. Mostly…
Love this quote and tell it to friends often. I strive to be the clever and lazy officer. It was also eye opening to meet the first hardworking+stupid individual of my career and see just how much damage they really…
impressive to me, but sadly i feel a little misleading since this is only the data-science part of life sciences. every few weeks though i test claude and chatgpt on their scientific reasoning and it has definitely…
i'm very late but i just wanted to give you kudos for a succinct yet spot-on comment on the state of funding. you captured everything i've been trying to put into words and failing miserably at.
the recent drama about science funding to me highlights one of the main problems with our grant-based distribution system: which is that it is unsurprisingly very frail to fast-moving changes in government and society…
The stem cell field is also quirky. IMO it is one of the most cutthroat, competitive, ruthless fields of life sciences that is new enough in history to still have a bunch of pioneers fighting to be the figurative…
> They're in a sticky spot where their most successful customer is one that they will never see another dime from, and there's not really a way around it. naive question: why has no one made an app with the reverse…
sadly no, this is not a thing and it's critically needed. top on my list of things to do if i were a billionaire: launch an institute for the sole purpose of reproducing other's findings.
the problem is two-fold in my opinion. firstly, there are basically no legal repercussions for scientific misconduct (e.g. falsifying data, fake images, etc.). most individuals who are caught doing this get either 1) a…
sadly it looks like seanhunter was correct, shame.
every few months i like to ask chatgpt to do the "thinking" part of my job (scientist) and see how the responses stack up. at the beginning 2022 it was useless because the output was garbage (hallucinations and fake…
i am very glad to see others (presumably non-scientists) in this thread dunking on the false paradigm that "peer review = true". anyone who peddles this notion is naive or a moron. while the author is correct that the…
some added context (both my parents are/were in the Foreign Service): your location is assigned based on a competitive bidding system where you select from a list of cities to do your next tour. some countries/cities…
the small molecule is SW033291, papers are required to publish this specific detail but second order news sources tend to avoid the technical details.
at the dissolution and decentralization of empires feudalism in it's many forms historically seems to be the most common outcome. i would say that we firmly live in the American Empire with techno-feudalistic…
my own institution launched an internal investigation into a professor who i know for a fact committed fraud and was "unable to prove intentional wrongdoing". academic institutions have taken the "this never happens…
the greatest travesty of modern science is that fraud is not illegal. in every other industry that i can imagine, purposely committing fraud has been made illegal. this is not the case in modern science, and in my…
I think about this quite a lot. I’ve come to the conclusion that in the past acting with integrity was rewarded and lacking integrity was punished. In 2025 it seems integrity is meaningless, “winning” is all that…
chatgpt making targeted "recommendations" (read ads) is a nightmare. especially if it's subtle and not disclosed.
My portfolio was +94% in 2024 and +52% in the past 6 months (I took a massive haircut thanks to April's tariff saga and by having biblical levels of greed...lesson learned). How do I declare for the inaugural Hedge Fund…
yup, anecdotally the majority of postdocs these days are internationals who are willing to work 60+ hour weeks on $50k a year, for the infinitesimal chance to land a R1 tenure-track faculty position. americans have no…
Painkillers like ibuprofen are NSAIDs which inhibit the enzyme COX1/2, reducing prostaglandin production. Prostaglandins are an inflammatory hormone that do a variety of things, but specifically PGE2 plays a role in…
I've always thought of these VC fueled expeditions to nowhere as the opposite. Wealth transfer from the owning class to the middle class seeing as a lot of these ventures crash and burn with nothing to show for it.…
I’m sorry who is who in this analogy. Because if internet/tech is the gun then the clear solution is “not giving your children guns”. Bad modern parents just give their kids an iPad.
On the topic of hammers: "if you don't hold the hammer at exactly 2.6cm from the end of the handle and strike the nail with 6N of force at an angle of 58 degrees then of course you won't get a good nail strike into the…
Just like AI seems like it's being used as a convenient scapegoat for the layoffs and trimming following the end of ZIRP, now we see it also being used to blame for the failures of our modern education system. Mostly…
Love this quote and tell it to friends often. I strive to be the clever and lazy officer. It was also eye opening to meet the first hardworking+stupid individual of my career and see just how much damage they really…