I'm not sure where you're getting your information from, but a lot of it is very incorrect and has a strong anti-pharma bias. For example: > Paradoxically if they were stepping away from the monoamine hypothesis, they…
Thanks for sharing your experience. I'm still surprised that more doctors aren't taking a proactive approach to telling their patients what to expect. I suspect part of it stems from lack of education, but I think some…
> Then there's the academic problem: the monoamine hypothesis (the underlying theory behind the actions and use of SSRIs etc) is at best a crude approximation with precious little in vivo data to support ideas that are…
> pharmas are able to start clinical trials and then shut them down without reporting result is a problem. As you've worked in the industry, I'm curious: What do you think could remedy this situation? Forcing all…
The study is interesting and worth following up on, but the biggest takeaway from your post is your statement that: > We don't know which way causality runs. The study found a correlation, not a causation, and even the…
Sure! Here is a somewhat recent study on the topic: http://www.sciencedirect.com/science/article/pii/S1053811911... Some of these studies are difficult to interpret without the appropriate background, though, because…
This is an egregious violation on many levels. It highlights a massive gap in the clinical trials process (companies can stop trials without reporting negative results) that really should be addressed. I think everyone…
> Now let's find out if this anti-depressant really helps anyone, or is it just another terrible drug with horrid side effects? If it doesn't help better than placebo; take it off the market? The claim that SSRIs are no…
> I'd like to see how I react to both together, but hesitant given my poor reaction to Adderall. When I was younger I remember preferring Ritalin over Adderall. I always advise against poly-pharmacy if possible.…
Everyone is different, of course, but after 10 years it would be reasonable to assume that your brain was well-adapted to many of the effects of the Adderall and that you were taking a reasonable therapeutic dosage with…
> Isn't "Do they respond to ADHD medication?" our only test? No, absolutely not. It's a common internet myth that response to ADHD medication is indicative of ADHD. In reality, nearly anyone who takes ADHD medication…
> Adderall is not the answer as these journalists like to claim though. It's useless for basically anything other than very rare usage and has difficult to manage loss of productivity during withdraw. It has an…
Unfortunately, most casual and first-time users associate Adderall with the honeymoon phase you spoke of, not the actual long-term therapeutic effects that come from proper therapeutic use and dosing schedules.…
> I believe that one of the most "abused" drugs for "productivity" is currently Modafinil, far more powerful than Adderall and without all those side effects. Modafinil is easier to acquire than Adderall, but it…
I'm not sure where you're getting your information from, but a lot of it is very incorrect and has a strong anti-pharma bias. For example: > Paradoxically if they were stepping away from the monoamine hypothesis, they…
Thanks for sharing your experience. I'm still surprised that more doctors aren't taking a proactive approach to telling their patients what to expect. I suspect part of it stems from lack of education, but I think some…
> Then there's the academic problem: the monoamine hypothesis (the underlying theory behind the actions and use of SSRIs etc) is at best a crude approximation with precious little in vivo data to support ideas that are…
> pharmas are able to start clinical trials and then shut them down without reporting result is a problem. As you've worked in the industry, I'm curious: What do you think could remedy this situation? Forcing all…
The study is interesting and worth following up on, but the biggest takeaway from your post is your statement that: > We don't know which way causality runs. The study found a correlation, not a causation, and even the…
Sure! Here is a somewhat recent study on the topic: http://www.sciencedirect.com/science/article/pii/S1053811911... Some of these studies are difficult to interpret without the appropriate background, though, because…
This is an egregious violation on many levels. It highlights a massive gap in the clinical trials process (companies can stop trials without reporting negative results) that really should be addressed. I think everyone…
> Now let's find out if this anti-depressant really helps anyone, or is it just another terrible drug with horrid side effects? If it doesn't help better than placebo; take it off the market? The claim that SSRIs are no…
> I'd like to see how I react to both together, but hesitant given my poor reaction to Adderall. When I was younger I remember preferring Ritalin over Adderall. I always advise against poly-pharmacy if possible.…
Everyone is different, of course, but after 10 years it would be reasonable to assume that your brain was well-adapted to many of the effects of the Adderall and that you were taking a reasonable therapeutic dosage with…
> Isn't "Do they respond to ADHD medication?" our only test? No, absolutely not. It's a common internet myth that response to ADHD medication is indicative of ADHD. In reality, nearly anyone who takes ADHD medication…
> Adderall is not the answer as these journalists like to claim though. It's useless for basically anything other than very rare usage and has difficult to manage loss of productivity during withdraw. It has an…
Unfortunately, most casual and first-time users associate Adderall with the honeymoon phase you spoke of, not the actual long-term therapeutic effects that come from proper therapeutic use and dosing schedules.…
> I believe that one of the most "abused" drugs for "productivity" is currently Modafinil, far more powerful than Adderall and without all those side effects. Modafinil is easier to acquire than Adderall, but it…