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  1. How to Decide What to Build (dcgross.com)
    630 points by danicgross 175
  2. Blood test that finds 50 types of cancer is accurate enough to be rolled out (theguardian.com)
    630 points by kieranmaine 377
  3. Show HN: Timelinize – Privately organize your own data from everywhere, locally (timelinize.com)

    Hey HN -- thanks for showing interest in this. Happy to collaborate on this project. I'm hoping to get it stable soon so my own family can start using it. I've been working on this for about 10+ years, nights and…

    630 points by mholt 76
  4. Ask HN: How are you using GPT to be productive?

    With GPT so hot in the news right now, and seeing lots of impressive demos, I'm curious to know, how are you actively using GPT to be productive in your daily workflow? And what tools are you using in tandem with GPT to…

    629 points by yosito 735
  5. Ask HN: What technologies did you learn in 2018?

    What technologies have you invested time in learning that you are going to keep using/experimenting/learning about in the next year? I'm a professional Android engineer, and as for me: I learned Kotlin and use it at…

    629 points by vchernobyl 601
  6. The tiny corp raised $5.1M (geohot.github.io)
    629 points by super256 317
  7. Hardening Firefox with Anthropic's Red Team (anthropic.com)

    The bugs are the ones that say "using Claude from Anthropic" here: https://www.mozilla.org/en-US/security/advisories/mfsa2026-1... https://blog.mozilla.org/en/firefox/hardening-firefox-anthro...…

    629 points by todsacerdoti 48
  8. How to communicate when trust is low without digging yourself into a deeper hole (charity.wtf)
    629 points by zdw 281
  9. Hubble telescope has new lease on life after computer swap appears to fix glitch (sciencemag.org)
    629 points by sohkamyung 231
  10. Live Nation illegally monopolized ticketing market, jury finds (bloomberg.com)

    https://www.nytimes.com/2026/04/15/arts/music/live-nation-an..., https://archive.ph/KA1wV https://www.theverge.com/policy/912689/live-nation-ticketmas...

    629 points by Alex_Bond 29
  11. The Best Birth Control In The World Is For Men (techcitement.com)
    629 points by d2vid 196
  12. Git Notes (tylercipriani.com)
    629 points by thcipriani 128
  13. Air pollution fell substantially as Paris restricted car traffic (washingtonpost.com)
    629 points by perihelions 563
  14. 24-core CPU and I can’t type an email (randomascii.wordpress.com)
    629 points by ghuntley 310
  15. The $300B Google-Meta advertising duopoly is under attack (economist.com)
    629 points by acconrad 547
  16. AWS Lambda pricing now per ms (aws.amazon.com)
    629 points by astuyvenberg 275
  17. Dropbox S-1 (sec.gov)
    629 points by i0exception 378
  18. Managers with a business degree reduce employees' wages, do not increase profit (nber.org)
    629 points by jstx1 258
  19. I have a bad feeling about this (raganwald.posterous.com)
    629 points by llambda 179
  20. It’s cheaper to build multiple native applications than one responsive web app (hueniverse.com)
    629 points by cdnsteve 304
  21. Time to Dump Time Zones (nytimes.com)
    629 points by prostoalex 536
  22. ToS;DR — TL;DR for Terms of Service and Privacy Policy (tos-dr.info)
    629 points by hugoroy 128
  23. Common mistakes in salary negotiation (interviewing.io)
    629 points by eamonnm 454
  24. Ask HN: Programs that saved you 100 hours?

    I learned about a ton of useful CLIs, desktop apps, and SaaS products from this thread (https://news.ycombinator.com/item?id=13887237). But it was posted 3 years ago, and perhaps some useful stuff has emerged in the…

    629 points by zJayv 516
  25. Ethereum 2.0 launches (twitter.com)
    629 points by 0x64 603