Truly a terrible disease. The fear associated with it must be horrible for pregnant women. I wonder if the warning would be the same if the virus had killed or disfigured 4000 newborns instead of affecting fetuses. We seem to put more emphasis on the health of a fetus than anything (prenatal supplements, mother's habits, etc).
It isn't so much that it is killing many. It isn't. The problem is that these babies are being born relatively healthy, but with debilitating mental/brain deficiencies that will follow them and their families for decades.
This, on top of all the other mosquito-born diseases, may finally convince the authorities/ethical commitees/whoever has the decision power to use this CRISPR specie-killing scheme talked about some time ago. It's scary, but it's badly needed.
Because as sibling comment said, asking people not to get pregnant will never work, anytime anywhere in the world.
That cannot be allowed to be a thing. Mosquitoes fill an important niche in a great many ecologies. Any society capable of creating such a thing will surely be able to create a vaccine or treatment. That is where energies should be focused.
> Many species of insect, spider, salamander, lizard and frog would also lose a primary food source. In one study published last month, researchers tracked insect-eating house martins at a park in Camargue, France, after the area was sprayed with a microbial mosquito-control agent1. They found that the birds produced on average two chicks per nest after spraying, compared with three for birds at control sites.
> Most mosquito-eating birds would probably switch to other insects that, post-mosquitoes, might emerge in large numbers to take their place. Other insectivores might not miss them at all: bats feed mostly on moths, and less than 2% of their gut content is mosquitoes. "If you're expending energy," says medical entomologist Janet McAllister of the Centers for Disease Control and Prevention in Fort Collins, Colorado, "are you going to eat the 22-ounce filet-mignon moth or the 6-ounce hamburger mosquito?"
> With many options on the menu, it seems that most insect-eaters would not go hungry in a mosquito-free world. There is not enough evidence of ecosystem disruption here to give the eradicators pause for thought.
Go to the north. Wait. Wait until the sky darkens and you are afraid to venture outside. Then say that mosquitoes don't matter. There is some evidence that they consume more caribou, by weight, than the wolves.
I went to grad school with a lot of ecologists (not an ecologist myself). I've seen countless presentations about anthropogenic threats to all kinds of ecosystems. I've never seen anything that included mosquitoes as anything but a disease vector, and I've heard numerous opinions saying that mosquitoes are the one class of animal whose absence would not be noticed by the ecosystem. To back that claim up, I have the micro-review in Nature that I linked above. You can find more sources by following the citation web from it.
Gene drives are certainly a powerful and dangerous technology. But if you want to argue against using a gene drive on mosquitoes from a scientific standpoint, you need to present scientific evidence.
> I've never seen anything that included mosquitoes as anything but a disease vector,
There are entire branches of ecology studying (among other things) the role of mosquitoes in ecosystems. Limnology for example.
> I've heard numerous opinions saying that mosquitoes are the one class of animal whose absence would not be noticed by the ecosystem
Define "numerous"
I can't understand how somebody could claim that nothing will occur if we wipe an entire "class" of animals comprising more than 3000 species and that are linked with almost all in freshwater ecosystems in its quadruple role of prey, predator, pollinisator and vector. Hundred of species of vertebrates of economic interest to man depend on them, probably.
The question is if "Mosquitoes fill an important niche in a great many ecologies".
The Nature article that ak217 linked to describes the north as the primary special case: "Taken all together, then, mosquitoes would be missed in the Arctic — but is the same true elsewhere?"
Otherwise, they don't seem to have a key niche, eg, as a food source for insect-eaters.
> Ultimately, there seem to be few things that mosquitoes do that other organisms can't do just as well — except perhaps for one. They are lethally efficient at sucking blood from one individual and mainlining it into another, providing an ideal route for the spread of pathogenic microbes.
It ends with a quote:
> "They don't occupy an unassailable niche in the environment," says entomologist Joe Conlon, of the American Mosquito Control Association in Jacksonville, Florida. "If we eradicated them tomorrow, the ecosystems where they are active will hiccup and then get on with life. Something better or worse would take over."
Thus, the article argues that mosquitoes do not fill an important niche in a great many ecologies, though they definitely fill an important niche in the arctic.
It sounds like scientists thought about it, decided that their niche would quickly be filled by other insects - "Life would continue as before — or even better":
Eh, from another angle mosquito-killing gene editing (MKGE) is one of the least destructive ways humans can try to kill all mosquitoes.
Killing all mosquitoes isn't a new idea or one that we haven't tried putting into practice. For instance, take a look at satellite photos of Long Island sometime[0]. You see all those straight lines dug along the coasts? That's where we destroyed thousands of acres of marshes for the purpose of killing mosquitoes around New York.
We also led a pretty destructive campaign against them in the American south, as part of essentially eliminating malaria in the United States. Again, countless wetlands destroyed along with spraying some absurd amount of highly effective pesticides like DDT everywhere.
MKGE is like the most environmentally friendly way we've ever tried to kill all mosquitoes.
I don't believe they do, because the death rates just aren't that high. Population-limiting factors for Humans have historically been mostly food supply and childhood diseases. I've heard that Malaria wasn't so much of a problem until people where driven into malaria-infested areas due to population growth.
Today the population limiting factor for Humans seems to be women's education. No kidding, this seems to be the number one factor in birth-rates. The more education women are getting the less babies are born. And I am generally in favor of both, more education and less procreation.
In certain areas, but resistance to the chemical was observed even in early usage. It's highly unlikely malaria would've been eliminated by DDT use in the long run.
Right now, the best response we have is to target mosquito breeding sites. Mosquitos need still water to lay eggs, which it typically found in drains, plant pots, uncovered debris (bottles, tires), swimming pools, etc.
What is the rate of ultrasounds in these countries? This deformity is very detectable. I know that the only treatment, if one can call it that, is termination, but this may be important in coming years.
In many communities mothers would commonly opt to terminate these pregnancies. It's harsh and vicious, but it does happen. We need to think about such sociological differences when predicting this disease. The wave of birth defects hitting Brazil may not be replicated in countries where ultrasounds are standard and attitudes to termination differ.
Latin America in general is very Catholic and very Pro Life. Abortions are often illegal or only legal in select cases. Even if the disease was detectable, they mothers may not terminate.
That's precisely my point. The rate of birth defects is dependant on more than the spread of the disease. The epidemiologists predicting the long term situation will have to account for this.
El Salvador has the Marco Rubio/Ted Cruz abortion policy. It's illegal even if the fetus is unviably sick, even as a result of rape, and even if the mother will die from the pregnancy.
These defects are often not detectable via ultrasound until late second / early third trimester, where abortions are more expensive, more emotionally scarring, and more illegal.
Diseases transmitted by mosquitos have increased tremendously in the last decade, Especially in developing nations. I am from India and we never used to hear about cases of Dengue or Chikungunya 10-15 years ago. Now its all too common. Looks like this is a similar disease, now with links to microcephaly.
Dramatic increase in city populations, poor infrastructure result in increased mosquito breeding grounds
These nations need to heavily invest in taking out disease carrying mosquitoes or situations like these are only going to increase.
Diseases like this are something that forces you go to the doctor, where its gonna gain a diagnosis. With diseases like Zika and Chikungunya the big problem is globalization and air travel.
How is a doctor supposed to diagnose a Virus like Zika without advanced lab tests? The symptoms are non-specific and often non-obvious. In fact, I doubt Zika virus was regularly tested for.
Significant number, maybe. Penetration of medical services in these countries has increased quite a lot in the same time span. But, impact of this depends on the type of disease.
Significant increase in breast cancer cases for example is I believe a direct result of increased diagnosis.
But, for the increase in cases of viral diseases, I believe the majority cause is due to things like more dense population, unsanitary conditions and poor infrastructure.
I'd exclude breast cancer because it's detectable with non-medical means before it becomes fatal. I also wasn't speaking so much about medical incidence statistics, but more about perceptions.
> The epidemiology of dengue fevers in the Indian subcontinent has been very complex and has substantially changed over almost past six decades in terms of prevalent strains, affected geographical locations and severity of disease. The very first report of existence of dengue fevers in India was way back in 1946[15]. Thereafter, for the next 18 years, there was no significant dengue activity reported anywhere in the country. In 1963-1964, an initial epidemic of dengue fever was reported on the Eastern Coast of India[7,16–20], it spread northwards and reached Delhi in 1967[21] and Kanpur in 1968
then continues with many more recent epidemics of Dengue in India throughout the decades.
I can think of several other hypotheses, besides a rise in mosquito-transmitted diseases, which can fit your observation:
1) you didn't pay attention to it 15-20 years ago, or your memory has faded, 2) other diseases, like polio and malaria, were more significant so played a larger role in health reporting, 3) people and news sources talk more about health issues now than then, 4) official counts which were deliberately under-stated are now becoming more realistic.
If this pope, and this crisis in his own back yard, aren't sufficient to compel a change in Catholic teachings on birth control, I think it's safe to assume it'll not happen for generations.
I am not sure how it "works" either. But, if the Catholic church could gradually change its position on slavery [1], surely it should be possible to do so on other matters as well.
95% of Catholicism is re-interpretation by the Church of their holy documents. Changing the mind of the church is definitely a thing - see heliocentrism.
Heliocentrism was a religiously-derived belief. There are certainly other examples - for some verses in the bible, there are hundreds of interpretations.
That's the official line of the catholic church, yes. Not without internal protests, and not without quite a few people, including clergy, ignoring it, but still. No active birth control, married or not.
The fact that (unlike e.g. AIDS, where this policy also has been under fire) this isn't sexually transmitted and supposedly temporary might make it easier to change the line? I think the GP is right that now seems to be a prime moment for it to happen.
Terrifying. Doing some quick back of the envelope calculations: 1,000,000 people in Brazil got the virus, and there are 4,000 cases of microcephaly. Let's assume that most of these are caused by the virus (pre-virus level of microcephaly were very low) and assume half of the people are women. Also assume roughly two pregnancies over a women's life, and an average life expectancy of 73 years.
This would mean that of the 500,000 women that got the virus, roughly 2% of these women were pregnant while getting the virus, which equates to 10,000 women, resulting in 4,000 cases of microcephaly. This would be a 40% chance of microcephaly when a woman catches the virus during pregnancy. That is absurdly high for a virus that is starting to become (or already is) an epidemic.
There's many assumptions in the calculation and I'm sure the medical profession has much better numbers. As I said it's a back of the envelope. But even if the chances are 20% or 10%, that is still extremely high and worrying. The recommendation not to get pregnant in countries where the virus is active suddenly makes sense.
> The recommendation not to get pregnant in countries where the virus is active suddenly makes sense
How is one going to implement such a policy ? one can't make people stop having sex and AFAIK El Salvador is very religious (no abortions...) and poor (no contraceptives ...). This epidemic concerns the whole world IMHO and we should put a maximum of resources into finding a cure or a vaccine (if none exist yet) ASAP. Now i'm even hearing that this virus might be a STD ... scary.
Condoms don't really work for preventing pregnancy though, the failure rate is too high for that. They have success at reducing pregnancy rates, but not at stopping it.
No contraceptive is perfect, and the rates vary between methods. Note that some of the methods in the table can be combined (and often are), thus lowering the overall chance of pregnancy.
ars's comment seems a bit extreme; while condoms don't perfectly prevent pregnancy, they are certainly quite effective at reducing the chance of it.
Correct. They don't prevent, they reduce. Used at typical rates, 18% of women will still get pregnant every year (reduced from 85% - it's a large reduction, but I would not call it prevent).
For a situation like this, with (according to geertj's calculations) 40% chance of severe birth defect, that's far too much.
Condoms are not the solution here - in fact I think they do more harm than good because people think they work (like you did), while they are not sufficiently effective.
Result:
When used consistently and correctly, condoms are 98% effective in preventing pregnancy and are the only form of birth control that also can prevent STIs.3,7,8 This is why it's important to follow directions for correct use.
>>When we talk about the effectiveness of any kind of contraception, including condoms, we reference two different groups of figures. One is perfect use: that means a person always uses their method and always uses it correctly. These results are often figured via lab studies, where perfect use can be verified. The other is typical use: how your average person generally uses a method. For instance, it’s typical use for women to take a birth control pill late or miss one now and then, have a patch slip off, or only put a condom on after intercourse has already begun. Typical use rates also include not using a given method at all. In other words, the typical use rate for condoms is about people who, when asked what method of birth control they use, say condoms, even if they only use a condom one out of every three times they have intercourse. - See more at: http://rhrealitycheck.org/article/2009/10/02/get-real-how-we...
<<
So in essence a condom works if you use it and if you don't use it and get pregnant it is not very effective. WTF? At this point I'm cursing for wasting my time.
No one is lying. Parent's 18% is the figure for male condom use in reality, vs your 2% for consistent and correct use.
The point is that if you have an entire population of people who say that their primary method of contraception is male condom, you should expect an unplanned pregnancy rate closer to ~18% per year than 2% per year.
Those numbers are completely useless because they don't question the reliability of condoms but the more social aspects of it (eg: how good are people on average in using them). If you are capable of using birth control then they will work just fine to prevent a pregnancy.
They're also percentages with no actual absolute numbers. People often interpret percentages while falsely assuming that other things remain constant. For example, if condom use is accepted and people come to believe condoms work, they may be more likely to have sex more frequently because their fear of contracting STDs and pregnancy have decreased. This means that the failure rate no longer pertains to the original frequency of sexual intercourse but the new one. This way, the number of actual failures (vs. just the rate) may exceed the original, and with it the number of abortions. This way, condoms actually enable the behavior whose consequences they were intended to limit. Yay, big picture.
Well, they don't have any problem with correcting hereditary problems in the womb[1], and it appears okay to straight up not have kids if you know you have a problem that's going to affect the fetus as well[2].
What they absolutely aren't okay with is finding out the child has microcephaly, and aborting as a result.
It's my own personal read on canon law that giving birth in such an environment, to the point where the civil authorities are saying "please don't", would present an unacceptable risk to the child, and thus be immoral, and thus be a sin.
Why does sex seem to get a pass for "you can't control your biological impulses" when other drives don't?
- We're driven to eat as well, and have a growing problem with obesity. At least, when you eat too much, you're only harming yourself. Yet, we (the society "we") tut at the obese, in some cases make fun of them. "Why can't you control yourself?" we say. "Put down the fork!" says another.
- We have a drive to be social, yet humans are pretty well controlled when it comes to expressing that drive at the wrong times in the wrong places.
- It's expected to be protective of your family, but in another time, that would have meant meting out lethal punishment to an interloper. Now, doing that lands you a prison sentence.
Without moralizing on any of this:
The drive to reproduce, we somehow don't expect people to stop screwing when it's likely that doing so will have really awful consequences for a perfectly innocent life. Either now, in the case of a virus causing congenital defects, or in other cases, such as not being able to support a child. We throw our hands up, say "welp, abstience doesn't work, knock yourselves out", and try to work around the problem with birth control (something which still has a <100% chance of stopping unwanted births)
Why is this? Surrender to the implacable force of human nature doesn't seem to be the answer, seeing as how we've at least partially tamed most other impulses, or at least refused to give up.
WRT obesity, there is a big drive to recognize that this is not a really controllable impulse (appetite and metabolism differences are strongly biologically determined) and a lot if the effort (diets, for example, or low-calorie substitutes) goes into figuring out how to fulfill the impulse while reducing the harm - similar to STD protection and birth control.
WRT socializing, we definitely have norms about controlling the drive to socialize, but I don't know many people who advocate complete isolation.
Similarly with sex. What you characterize as a "you can't control biological impulses" position usually specifically targets abstinence - that is not a fight you can win. But those same people are often totally in favor of more limited control of the sex drive. Laws against rape (statutory or otherwise), norms against romances on the workplace or military service where a power imbalance exists, norms against just plain moving too fast with someone new - these are all very broadly supported.
I think we need to define abstinence a bit more carefully. In most cases, it's meant as a temporary thing, not permanent virginity.
Teens: Don't have sex till later, you don't want babies yet.
Women in this country: Don't have sex till later, you don't want babies with birth defects.
Church: Don't have sex till later (marriage), you'll offend God
So what is the substantial difference between the socially accepted "don't have sex in the military, wait till you're out" and the quickly becoming socially unaccepted "don't have sex for this set period of time"? You just did it right here, characterizing it as a fight you can't win.
It seems... strange, to expect responsibility and prioritization of biological goals from people at some times and not others.
The military does not demand abstinence from sex for years - if they did, it would be an epic disaster. The relationships (sexual and social) that are prohibited are very specific in nature [1]. Soldiers have sex with civilians when on leave in the countries where they're stationed, they have sex with other soldiers they they don't have command authority over and that aren't in the same small unit, they have sex when they're back home between tours.
Please address the central point rather that seizing on an ambiguity in my post.
That point being, that sexual activity in the armed forces is still controlled and sometimes that drive cannot be satisfied for relatively long periods, and this is commonly accepted.
I am trying to address your central point. Your point is, as far as I can understand, "if it's okay for the military to control soldiers' sex lives in X, Y, and Z ways, why isn't it okay to similarly control teenager's and unmarried people's sex lives?"
But the kinds and degrees of control that work successfully are totally different from the kinds that you're suggesting. The "seizing on an ambiguity" is actually seizing on the fact that the policies you claim support abstinence's effectiveness are not policies of abstinence.
Again, you seem to conflate abstinence with permanent virginity. No, absolutely not.
This is really, really simple. Are you not supposed to have sexual contact for X period of time? If yes, you are abstinent for that period. The period varies, sometimes longer, sometimes shorter, but the definition still applies.
That would classify "don't have sex until the weekend" as an abstinence policy, which is ridiculous.
If X period is repeating on and off on semi-regular schedule, then it's not an abstinence policy. That's just scheduling sex. If it's a single continuous period, then it might be an abstinence policy.
It's not really that strange when you think about it. We are animals that have biological urges. However, we are social animals that live in a society. As a result, we must balance our biological pressures with our societal ones.
Let's just take the first example - teens who do not want to get pregnant.
I'm not sure what you find strange about this. Teenagers will feel the desire to have sex, but they (and/or their families) will be aware that having a baby at a young age can limit your freedom later in life. Thus, teenagers are told to either wait until they are older to have sex, or be sure to use contraception.
> It seems... strange, to expect responsibility and prioritization of biological goals from people at some times and not others.
Control over our base biological goals is a key part of what makes us civilised.
azernik already answered regarding the drive. Just wanted to comment regarding:
> At least, when you eat too much, you're only harming yourself.
That's not true, just as "if you smoke / drink you're only harming yourself". Provided you have a family you're putting them at risk of your early death. You're both passing down more likely obesity when pregnant (2015 study, but don't have time to google it now) and teaching kids the behaviour that likely leads to obesity for them too.
So yeah, you're actually harming your family not just yourself.
>Why does sex seem to get a pass for "you can't control your biological impulses" when other drives don't?
You probably have ancestors who could control their eating, but you have no ancestors who successfully controlled their sex drive. Most of our DNA probably comes from the most sexually active/driven humans that ever existed. Humans who could control it or were not as sexually driven didn't shape our DNA as much.
That assumes it's best to attempt reproduction at all times. During a food shortage, people who can control their urges would fair better than those who end up getting pregnant and starving to death.
That's a ridiculous assumption, on so many levels.
A woman can get raped and end up pregnant. She can have zero interest in sex and still reproduce.
"Evolution" favors those who survive long enough to reproduce. Merely being born is not sufficient. If you have 20 kids and none of them live to adulthood, your genes die out. There is a correlation (that seems to run two ways) between having fewer kids and having them survive. Cultures with high child mortality also have high birth rates. So fucking like rabbits does not by itself ensure survival.
Generally speaking, the human race places a high value on a faithful woman. A woman who is faithful is more likely to get support from the father of her children, thus her children are more likely to thrive. Most likely, "bastard" is a swear word or insult because, historically, having a child out of wedlock tended to doom both mother and child to extreme poverty.
Why does sex seem to get a pass for "you can't control your biological impulses" when other drives don't?
That isn't really the problem. The problem is more complicated than that. It includes:
Delusion: Modern peoples think birth control is more reliable than it really is.
Guilt: I have seen studies that indicate that certain populations of women have a high incidence of pregnancy because they feel planning for sex makes them a slut, but just getting swept away with emotion makes it "love" and that is somehow OK. So, birth control is proof that "I am a slut."
Religion: Some religions (Catholic church) forbid use if birth control.
I am sure I could add to that list, but I have other things I need to do.
Sex isn't just a biological impulse. Many couples feel that it's important to their bond. One might respond more reductively with "why does the biological need for oxytocin to maintain intimacy get a pass" or somesuch, but the fact is that sex is never something that our evolution needed to control or limit. Having some sex is absolutely necessary for the species to survive. You're comparing that with maladaptive behaviors, whereas it's the exact opposite. You might as well expect people not to eat at all.
You must realize how ridiculous your post is. Sex can and does play a role in intimacy, but we do possess brains that can prioritize goods and sacrifice the lesser ones for the greater ones when necessary. It may requires work and habit formation, and some suffering, but it's possible. If all that is keeping your relationship together is sex, then you have larger issues you must address. The rest you've written is just woo.
Reproducing when the result will end up in a damaged child, or one you can't support, isn't maladaptive?
This is what I mean - we can obviously prioritize our needs and put a lid on biological drives when social needs demand for, pretty much everything else. Why is it so strange to expect that same restraint when it comes to sex?
Frankly, you're premise is flatly wrong; other drives get passes just as much as sex does or more; the people that take the contrary attitudes you point to on some other biological drives tend also to be equally or more judgemental of others when it comes to sex, and plenty of people who dont get judgemental about those other things get quite judgemental about other peoples sexual habits.
Claiming that sex is the biological drive that gets a pass compared to all others is completely detached from reality.
And the "advocating abstinence doesn't work" position isn't something that comes about out of nowhere and bias that sex is special, its the result of studies of how well that messaging works
Manifestly, empirically, abstinence advocacy is generally ineffective.
I'm not referring to judgemental-ness nearly as much as I am tenacity. It seems to be a foregone conclusion that people can't control when they have sex and that it's fruitless to suggest otherwise.
That same conclusion does not seem to apply to eating, socializing, and other base drives.
It's not surprising. Part of it is that the sexual appetite is particularly powerful. Part of it is because people are often weak in being able to endure (not talking repression here) the appetite when it manifests. Add to that the fact that sexual desire, when routinely gratified, can be habit forming. Then add to that a culture that obsesses over it and enables mindless sexual indulgence. Funny because lack of sex never killed a man. A lack of food can. Yet the desperate some claim to feel around sex would have you believe they were starving.
When such a greater good demands we abstain and we don't, we can justly be called selfish. It's something one needs to work on and struggle. Instead of waffling between prudery and licentiousness, one should work on one's sexual prudence (called the virtue of chastity, but the word, I fear, is uncool and infected with cooties, say the cool kids). It involves endurance, mindfulness, and possibly suffering.
Robin Williams once joked that god gave man two heads but just enough blood to operate one at a time. There's something to that.
Although it is only a recommendation, ignoring it might be more problematic than it seems right now. Of course, I'm not assuming that majority of Argentinian women would actually make careful review of all the risks, but still. Critically low newborn number for 2 years actually is a big deal. If we assume there won't be many babies in 2017 it means there won't be many 7 year olds in 2024. That probably means financing 2-nd class of elementary school that year is pretty pointless, which means problems if you actually had a healthy newborn child in 2017. That means virtually no need for goods & services targeting some specific age, critical hit for businesses.
On the other hand that means the opposite situation for those born in 2018-year, which also is not normal. (Overpopulated classes some 7 years later, at the very least.)
The birth rate in Brazil in 2015 was 14.46 births/1,000 population[1]. The twin rate is 8.8/1,000 births[2]. So, of 1,000,000 who got sick, roughly 14,300 were pregnant women[3], resulting in a 28% chance of microcephaly.
That still comes with a big asterisk since 80% cases of the disease in the general population are asymptomatic[4]. But(!) pregnant women are at increased risk for many diseases.
I wonder whether there is a window during pregnancy for a Zika infection causing microcephaly. eg, thalidomide caused different defects depending on which day of the pregnancy the mother took it -- take it on the Nth day and you get blindness, on the Mth day you get malformed limbs.
If it's something like "only a risk during the second trimester", then that 28% chance becomes "100% during second trimester".
I thought it was obvious... 2016 Summer Olympic games are being held in Brazil, the epicenter of the Zika virus pandemic. Aedes aegypti (a mosquito) is the disease vector. Tourists traveling to Brazil for the olympics will be at risk on contracting the disease and returning home. There are no known treatments or vaccines. The CDC has already issued warnings against traveling to these locations.
Aedes aegypti seems to be spreading in the US, with recent sightings in Sounthern and Central California -- not to mention natural populations in the South. So yeah, it could be really bad.
Yes but catching this in Brazil and pandemic are not necessarily linked. In this article I didn't see any reference that being infected in brazil will mean is a mosquito or other transmission in your home country is likely. I know in my country of Australia only one species of mosquito can potentially carry this virus, and they exist is in a remote region itself even if they can get this virus from the human that caught it and returned to a non-infected country.
Do you see where I'm coming from? I'm not saying this couldn't be a point to spread this virus around the world. However I'm not seeing any information that confirms this is a real risk other than people from around the world will be going into a live infection region. It takes much more that people simply visiting this area to make this into a Zika virus pandemic.
It's mind-boggling to think of the societal effects this will have at the nationwide level for the countries where this is so prevalent. Entire programs that will need to be increased or completely created anew to handle the amount of people affected with microcephaly.
Likewise, depending on how effective the government's urging will be, imagine being one of the few children born during those two years, having only 3 other children in your class through your entire primary and secondary education (I'm not sure what the El Salvador schooling program actually is, so these are large assumptions; but I imagine at this point, not entirely outside the realm of possibility).
Let's all remember that abortion is illegal in El Salvador, even in cases of rape. A woman who is raped and who also gets the Zika virus has no recourse. This is a very Catholic country. Access to birth control is extremely difficult. This new government recommendation is in conflict with dozens of other laws that the El Salvador government has passed, all of which are designed to maximize pregnancy.
Indeed, let's not forget that their anti-abortion laws are so strict that women have been imprisoned for more than a decade for having miscarriages, and premature (healthy) births.[0]
Seems a high risk if you get pregnant in El Salvador at any time.
Could you imagine if China had the threat of a virus to ensure people stopped breeding for two years? Imagine the help that would've done to their depopulation campaign!
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[ 3.0 ms ] story [ 167 ms ] threadI don't think the mosquito-killing gene editing technology is ready for deployment yet...
That cannot be allowed to be a thing. Mosquitoes fill an important niche in a great many ecologies. Any society capable of creating such a thing will surely be able to create a vaccine or treatment. That is where energies should be focused.
Wiping them out would be a serious error.
> Many species of insect, spider, salamander, lizard and frog would also lose a primary food source. In one study published last month, researchers tracked insect-eating house martins at a park in Camargue, France, after the area was sprayed with a microbial mosquito-control agent1. They found that the birds produced on average two chicks per nest after spraying, compared with three for birds at control sites.
> Most mosquito-eating birds would probably switch to other insects that, post-mosquitoes, might emerge in large numbers to take their place. Other insectivores might not miss them at all: bats feed mostly on moths, and less than 2% of their gut content is mosquitoes. "If you're expending energy," says medical entomologist Janet McAllister of the Centers for Disease Control and Prevention in Fort Collins, Colorado, "are you going to eat the 22-ounce filet-mignon moth or the 6-ounce hamburger mosquito?"
> With many options on the menu, it seems that most insect-eaters would not go hungry in a mosquito-free world. There is not enough evidence of ecosystem disruption here to give the eradicators pause for thought.
This is not true, and it's irresponsible to repeat it as fact.
Source please. I am not aware of any study that confirms this statement. See also http://www.nature.com/news/2010/100721/full/466432a.html.
I went to grad school with a lot of ecologists (not an ecologist myself). I've seen countless presentations about anthropogenic threats to all kinds of ecosystems. I've never seen anything that included mosquitoes as anything but a disease vector, and I've heard numerous opinions saying that mosquitoes are the one class of animal whose absence would not be noticed by the ecosystem. To back that claim up, I have the micro-review in Nature that I linked above. You can find more sources by following the citation web from it.
Gene drives are certainly a powerful and dangerous technology. But if you want to argue against using a gene drive on mosquitoes from a scientific standpoint, you need to present scientific evidence.
There are entire branches of ecology studying (among other things) the role of mosquitoes in ecosystems. Limnology for example.
> I've heard numerous opinions saying that mosquitoes are the one class of animal whose absence would not be noticed by the ecosystem
Define "numerous"
I can't understand how somebody could claim that nothing will occur if we wipe an entire "class" of animals comprising more than 3000 species and that are linked with almost all in freshwater ecosystems in its quadruple role of prey, predator, pollinisator and vector. Hundred of species of vertebrates of economic interest to man depend on them, probably.
The Nature article that ak217 linked to describes the north as the primary special case: "Taken all together, then, mosquitoes would be missed in the Arctic — but is the same true elsewhere?"
Otherwise, they don't seem to have a key niche, eg, as a food source for insect-eaters.
> Ultimately, there seem to be few things that mosquitoes do that other organisms can't do just as well — except perhaps for one. They are lethally efficient at sucking blood from one individual and mainlining it into another, providing an ideal route for the spread of pathogenic microbes.
It ends with a quote:
> "They don't occupy an unassailable niche in the environment," says entomologist Joe Conlon, of the American Mosquito Control Association in Jacksonville, Florida. "If we eradicated them tomorrow, the ecosystems where they are active will hiccup and then get on with life. Something better or worse would take over."
Thus, the article argues that mosquitoes do not fill an important niche in a great many ecologies, though they definitely fill an important niche in the arctic.
- http://www.nature.com/news/2010/100721/full/466432a.html
- http://blog.chron.com/sciguy/2010/07/scientists-go-ahead-kil...
- https://cogito.cty.jhu.edu/43255/up-for-debate-should-we-era...
Of course, whether it's ethically right is worth considering, as is the possibility that the scientists have missed some unintended consequence.
Killing all mosquitoes isn't a new idea or one that we haven't tried putting into practice. For instance, take a look at satellite photos of Long Island sometime[0]. You see all those straight lines dug along the coasts? That's where we destroyed thousands of acres of marshes for the purpose of killing mosquitoes around New York.
We also led a pretty destructive campaign against them in the American south, as part of essentially eliminating malaria in the United States. Again, countless wetlands destroyed along with spraying some absurd amount of highly effective pesticides like DDT everywhere.
MKGE is like the most environmentally friendly way we've ever tried to kill all mosquitoes.
[0] https://www.google.com/maps/@40.6098489,-73.448941,1067m/dat...
Because, well, I don't think you have any idea what you are talking about.
I think people just repeat this dogmatically, it doesn't appear to be true.
But there are arguments about how necessary this role really is I guess.
Sounds like it will eliminate malaria and not mosquitos
In many communities mothers would commonly opt to terminate these pregnancies. It's harsh and vicious, but it does happen. We need to think about such sociological differences when predicting this disease. The wave of birth defects hitting Brazil may not be replicated in countries where ultrasounds are standard and attitudes to termination differ.
Some women who miscarried have been imprisoned.
Maybe this disease will make them change their repressive law, but it's not likely.
Significant increase in breast cancer cases for example is I believe a direct result of increased diagnosis. But, for the increase in cases of viral diseases, I believe the majority cause is due to things like more dense population, unsanitary conditions and poor infrastructure.
> The epidemiology of dengue fevers in the Indian subcontinent has been very complex and has substantially changed over almost past six decades in terms of prevalent strains, affected geographical locations and severity of disease. The very first report of existence of dengue fevers in India was way back in 1946[15]. Thereafter, for the next 18 years, there was no significant dengue activity reported anywhere in the country. In 1963-1964, an initial epidemic of dengue fever was reported on the Eastern Coast of India[7,16–20], it spread northwards and reached Delhi in 1967[21] and Kanpur in 1968
then continues with many more recent epidemics of Dengue in India throughout the decades.
I can think of several other hypotheses, besides a rise in mosquito-transmitted diseases, which can fit your observation:
1) you didn't pay attention to it 15-20 years ago, or your memory has faded, 2) other diseases, like polio and malaria, were more significant so played a larger role in health reporting, 3) people and news sources talk more about health issues now than then, 4) official counts which were deliberately under-stated are now becoming more realistic.
It's God's mind you have to "change", not the Pope's.
At least, if I understand Catholicism correctly.
[1]: https://en.wikipedia.org/wiki/Catholic_Church_and_slavery#Th...
After all, most people use birth control for economic reasons, not health reasons.
Are you sure that's really what they would prefer?
The fact that (unlike e.g. AIDS, where this policy also has been under fire) this isn't sexually transmitted and supposedly temporary might make it easier to change the line? I think the GP is right that now seems to be a prime moment for it to happen.
This would mean that of the 500,000 women that got the virus, roughly 2% of these women were pregnant while getting the virus, which equates to 10,000 women, resulting in 4,000 cases of microcephaly. This would be a 40% chance of microcephaly when a woman catches the virus during pregnancy. That is absurdly high for a virus that is starting to become (or already is) an epidemic.
There's many assumptions in the calculation and I'm sure the medical profession has much better numbers. As I said it's a back of the envelope. But even if the chances are 20% or 10%, that is still extremely high and worrying. The recommendation not to get pregnant in countries where the virus is active suddenly makes sense.
How is one going to implement such a policy ? one can't make people stop having sex and AFAIK El Salvador is very religious (no abortions...) and poor (no contraceptives ...). This epidemic concerns the whole world IMHO and we should put a maximum of resources into finding a cure or a vaccine (if none exist yet) ASAP. Now i'm even hearing that this virus might be a STD ... scary.
In reality man should also be educated and provided with lots of condoms.
No contraceptive is perfect, and the rates vary between methods. Note that some of the methods in the table can be combined (and often are), thus lowering the overall chance of pregnancy.
ars's comment seems a bit extreme; while condoms don't perfectly prevent pregnancy, they are certainly quite effective at reducing the chance of it.
For a situation like this, with (according to geertj's calculations) 40% chance of severe birth defect, that's far too much.
Condoms are not the solution here - in fact I think they do more harm than good because people think they work (like you did), while they are not sufficiently effective.
Result: When used consistently and correctly, condoms are 98% effective in preventing pregnancy and are the only form of birth control that also can prevent STIs.3,7,8 This is why it's important to follow directions for correct use.
Somebody is lying.
So in essence a condom works if you use it and if you don't use it and get pregnant it is not very effective. WTF? At this point I'm cursing for wasting my time.
"Perfect" use increases effectiveness, but even if you aren't just derpy about it, they can still fail.
I routinely see this assumption that birth control works perfectly if you just use it, and that simply isn't true.
The point is that if you have an entire population of people who say that their primary method of contraception is male condom, you should expect an unplanned pregnancy rate closer to ~18% per year than 2% per year.
What they absolutely aren't okay with is finding out the child has microcephaly, and aborting as a result.
It's my own personal read on canon law that giving birth in such an environment, to the point where the civil authorities are saying "please don't", would present an unacceptable risk to the child, and thus be immoral, and thus be a sin.
[1]: http://catholicstraightanswers.com/what-is-the-churchs-posit...
[2]: http://www2.loras.edu/~CatholicHE/Arch/Sexuality/Genetic_dis...
Don't expect a sudden 180 on birth control. The advice for people will be to abstain.
Which is a well-proven failed strategy.
Why does sex seem to get a pass for "you can't control your biological impulses" when other drives don't?
- We're driven to eat as well, and have a growing problem with obesity. At least, when you eat too much, you're only harming yourself. Yet, we (the society "we") tut at the obese, in some cases make fun of them. "Why can't you control yourself?" we say. "Put down the fork!" says another.
- We have a drive to be social, yet humans are pretty well controlled when it comes to expressing that drive at the wrong times in the wrong places.
- It's expected to be protective of your family, but in another time, that would have meant meting out lethal punishment to an interloper. Now, doing that lands you a prison sentence.
Without moralizing on any of this:
The drive to reproduce, we somehow don't expect people to stop screwing when it's likely that doing so will have really awful consequences for a perfectly innocent life. Either now, in the case of a virus causing congenital defects, or in other cases, such as not being able to support a child. We throw our hands up, say "welp, abstience doesn't work, knock yourselves out", and try to work around the problem with birth control (something which still has a <100% chance of stopping unwanted births)
Why is this? Surrender to the implacable force of human nature doesn't seem to be the answer, seeing as how we've at least partially tamed most other impulses, or at least refused to give up.
WRT socializing, we definitely have norms about controlling the drive to socialize, but I don't know many people who advocate complete isolation.
Similarly with sex. What you characterize as a "you can't control biological impulses" position usually specifically targets abstinence - that is not a fight you can win. But those same people are often totally in favor of more limited control of the sex drive. Laws against rape (statutory or otherwise), norms against romances on the workplace or military service where a power imbalance exists, norms against just plain moving too fast with someone new - these are all very broadly supported.
Teens: Don't have sex till later, you don't want babies yet.
Women in this country: Don't have sex till later, you don't want babies with birth defects.
Church: Don't have sex till later (marriage), you'll offend God
So what is the substantial difference between the socially accepted "don't have sex in the military, wait till you're out" and the quickly becoming socially unaccepted "don't have sex for this set period of time"? You just did it right here, characterizing it as a fight you can't win.
It seems... strange, to expect responsibility and prioritization of biological goals from people at some times and not others.
[1](http://www.army.mil/article/138222/Army_updates_reg_defining...)
That point being, that sexual activity in the armed forces is still controlled and sometimes that drive cannot be satisfied for relatively long periods, and this is commonly accepted.
But the kinds and degrees of control that work successfully are totally different from the kinds that you're suggesting. The "seizing on an ambiguity" is actually seizing on the fact that the policies you claim support abstinence's effectiveness are not policies of abstinence.
This is really, really simple. Are you not supposed to have sexual contact for X period of time? If yes, you are abstinent for that period. The period varies, sometimes longer, sometimes shorter, but the definition still applies.
If X period is repeating on and off on semi-regular schedule, then it's not an abstinence policy. That's just scheduling sex. If it's a single continuous period, then it might be an abstinence policy.
Or in other words, it needs to be semi permanent.
Let's just take the first example - teens who do not want to get pregnant.
I'm not sure what you find strange about this. Teenagers will feel the desire to have sex, but they (and/or their families) will be aware that having a baby at a young age can limit your freedom later in life. Thus, teenagers are told to either wait until they are older to have sex, or be sure to use contraception.
> It seems... strange, to expect responsibility and prioritization of biological goals from people at some times and not others.
Control over our base biological goals is a key part of what makes us civilised.
> At least, when you eat too much, you're only harming yourself.
That's not true, just as "if you smoke / drink you're only harming yourself". Provided you have a family you're putting them at risk of your early death. You're both passing down more likely obesity when pregnant (2015 study, but don't have time to google it now) and teaching kids the behaviour that likely leads to obesity for them too.
So yeah, you're actually harming your family not just yourself.
You probably have ancestors who could control their eating, but you have no ancestors who successfully controlled their sex drive. Most of our DNA probably comes from the most sexually active/driven humans that ever existed. Humans who could control it or were not as sexually driven didn't shape our DNA as much.
A woman can get raped and end up pregnant. She can have zero interest in sex and still reproduce.
"Evolution" favors those who survive long enough to reproduce. Merely being born is not sufficient. If you have 20 kids and none of them live to adulthood, your genes die out. There is a correlation (that seems to run two ways) between having fewer kids and having them survive. Cultures with high child mortality also have high birth rates. So fucking like rabbits does not by itself ensure survival.
Generally speaking, the human race places a high value on a faithful woman. A woman who is faithful is more likely to get support from the father of her children, thus her children are more likely to thrive. Most likely, "bastard" is a swear word or insult because, historically, having a child out of wedlock tended to doom both mother and child to extreme poverty.
Etc.
That isn't really the problem. The problem is more complicated than that. It includes:
Delusion: Modern peoples think birth control is more reliable than it really is.
Guilt: I have seen studies that indicate that certain populations of women have a high incidence of pregnancy because they feel planning for sex makes them a slut, but just getting swept away with emotion makes it "love" and that is somehow OK. So, birth control is proof that "I am a slut."
Religion: Some religions (Catholic church) forbid use if birth control.
I am sure I could add to that list, but I have other things I need to do.
This is what I mean - we can obviously prioritize our needs and put a lid on biological drives when social needs demand for, pretty much everything else. Why is it so strange to expect that same restraint when it comes to sex?
Claiming that sex is the biological drive that gets a pass compared to all others is completely detached from reality.
And the "advocating abstinence doesn't work" position isn't something that comes about out of nowhere and bias that sex is special, its the result of studies of how well that messaging works Manifestly, empirically, abstinence advocacy is generally ineffective.
That same conclusion does not seem to apply to eating, socializing, and other base drives.
When such a greater good demands we abstain and we don't, we can justly be called selfish. It's something one needs to work on and struggle. Instead of waffling between prudery and licentiousness, one should work on one's sexual prudence (called the virtue of chastity, but the word, I fear, is uncool and infected with cooties, say the cool kids). It involves endurance, mindfulness, and possibly suffering.
Robin Williams once joked that god gave man two heads but just enough blood to operate one at a time. There's something to that.
On the other hand that means the opposite situation for those born in 2018-year, which also is not normal. (Overpopulated classes some 7 years later, at the very least.)
So, yeah. This year starts pretty crazy.
You're asking how they will implement a policy to recommend something? Probably with some advertising and public service announcements I guess.
Why does that puzzle you so much?
That still comes with a big asterisk since 80% cases of the disease in the general population are asymptomatic[4]. But(!) pregnant women are at increased risk for many diseases.
[1] https://www.cia.gov/library/publications/the-world-factbook/...
[2] http://journals.plos.org/plosone/article?id=10.1371/journal....
[3] who carried to term
[4] https://www.washingtonpost.com/world/the_americas/brazilians...
If it's something like "only a risk during the second trimester", then that 28% chance becomes "100% during second trimester".
Aedes aegypti seems to be spreading in the US, with recent sightings in Sounthern and Central California -- not to mention natural populations in the South. So yeah, it could be really bad.
Do you see where I'm coming from? I'm not saying this couldn't be a point to spread this virus around the world. However I'm not seeing any information that confirms this is a real risk other than people from around the world will be going into a live infection region. It takes much more that people simply visiting this area to make this into a Zika virus pandemic.
Likewise, depending on how effective the government's urging will be, imagine being one of the few children born during those two years, having only 3 other children in your class through your entire primary and secondary education (I'm not sure what the El Salvador schooling program actually is, so these are large assumptions; but I imagine at this point, not entirely outside the realm of possibility).
Seems a high risk if you get pregnant in El Salvador at any time.
[0]: http://www.theguardian.com/global-development/2015/dec/17/el...
It's pretty much Saudi-Arabia levels of cultural villainy.
Is the virus just like the flu where we kill it and life goes on? Or is the virus like herpes where it gets repressed but permanently there?
Because if so then women should get sick on purpose, wait to get better. Then not have to worry anymore.
Just not worth the risk to go down there (Yes, my wife is pregnant)
Horrifying and I hope the impact can be reduced for the people living in the affected countries.