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I don't really understand what it says. As a layman in this topic, I'm curious if modifications like that can cause other effects?
This is interesting news, for the lack of a better word. I've met more than one person with downs syndrome. They have definitely enriched my life and shown me a different way of looking at the world.
Interesting, I wonder what else this might lead too! Encouraging we might be getting somewhere.

I used to live near a Down syndrome center where a bunch of folks lived and I remember this one lady who was kitted out with Britney Spears everything, lunchbox, t-shirt, hat, and headphones. Everyday I passed by the bus stop she would be dancing her heart out to a Britney track waiting for the bus and it made my world a little brighter.

I read the abstract but I'm still a bit confused. Will this help people who have down syndrome? Or is it a way to help future pregnancies?
This is fantastic news!
It was well on its way to being eliminated in much of the First World through screening during pregnancy at around 2-3 months. Alot of mothers were electing to terminate the pregnancy and perhaps try again.

Especially much of Europe which didn't quite have the moral objections against abortion that the US does, save for a few countries who still have substantial observant Catholics such as Ireland and Poland.

Here's a story about Iceland https://www.abc.net.au/news/2024-05-01/iceland-prenatal-test...

Hear me out: what if instead of subtracting one we added another one to even it out?
Can we remove the down side but keep the joy?
You can be joyous right now, just remove one self from all the negativity.
If I already have down syndrome, would this still work as an adult?
How would that even work, it feels like the body/brain would have to be reshaped?
I think it is worth a separate research that modern definition of progressive thought considers eliminating/treating a genetic malfunction "unethical".
It's not very long ago that race was considered a "genetic malfunction".

People are still looking for a genetic link to autism.

This would only be applicable to in-vitro fertilization, in which case there's no point in trying to remove the extra chromosome when you could just find another sperm donor that doesn't have Down Syndrome.
Using subtle sequence variants to distinguish and eliminate only the supernumerary chromosome, without harming the normal ones... I think that precision is a technical marvel
Down syndrome presents in different ways.

I wanted to respond to multiple comments with the touching speech of Frank Stephen (a man affected by Down syndrome) before the US Congress in 2017, so I'm posting it to the top level instead.

It's a complex issue but I think listening to Stephen will add a valuable perspective.

https://m.youtube.com/watch?v=vtS91Jd5mac&pp=0gcJCfwAo7VqN5t...

One person’s “cognitive impairment” is another’s empathy enhancement.
That's a very zero-sum way of looking at this.
This research gives me a bit of hope. Although it’s still early and far from clinical use, it’s encouraging to see new treatment ideas emerging. I really hope we see more progress like this in the future that can truly help patients and their families.
The comments on this here make me a bit scared tbh and shows yet again what a bubble this is. You people need to get out more and socialize with actual people.