I wish there was something like LEAN for biology. But there just isn't nearly enough data to build anything close to a good drug discovery simulator. To have a LEAN for drug discovery, we would need to simulate human…
It helps with bureaucracy and pipeline generation. That's valuable and frees up time and effort for scientists. But it's not generating new ideas or solving problems like in math/engineering. The problem is that biology…
Claude will just choose similar toolings as everyone. Orchestration is a really nice tool to have and this can definitely empower non-technical bench biologists. But the bottleneck isn't using the tools or even…
It orchestrated available open source tools to de novo generate and assess the designs. It is still really impressive that it has enough theory to use the tools correctly, but it isn't generating the residues from…
Yeah the calibration is really what makes it useful in practice for quick, small decisions. Asking a LLM to give scores to a problem will yield inconsistently scaled/anchored results that changes at a whim. The blog is…
They are going to run out of real world data very soon. AI labs need to hire non-cynical domain experts to build physical hardware/automation that can generate experimental data. They are hard to find though. Most…
I am getting the exact opposite experience. But it is probably because I am in a domain where code/software is a tool, not the product. I find myself learning exponentially faster and more. For example, I am working…
I don't disagree with Bambu from an operational standpoint, but disagree with their handling of this. They are offering a cloud infrastructure that allows users to remote control the printer via their software. If they…
I have a data science/engineering background. From my perspective, using AI is like mining the solution space for optimality. The solution space is the combinatorics of the billions of parameters and their…
I AI coded an entire platform for my work. It works great for me. I also recognize that this is not something I want to make into a commercial product because it was so easy that there's just no value. I think this…
Yeah this is the simpler and also effective strategy. A lot of people are building sophisticated AST RAG models. But you really just need to ask Claude to generally build a semantic index for each large-ish piece of…
Just write a Claude OS already.
I did this in the beginning and realized I never went back to it. I think we have to learn to embrace the chaos. We can try to place a couple of anchors in the search space by having Claude summarize the code base every…
Were there any discussion from either company about giving government access to consumer data from the the consumer product?
It's a different skillset and way of thinking. Engineers tend to think vertically deep on technical problems. With AI, you have to think horizontally broad and vertically up on the architectural problem. The trick is to…
Pretty cool technique using complementary overhangs and toehold sequences to generate a 3-way heteroduplex, ligate knick, and then remove barcode duplex. They don't give much details on how the barcode duplex is removed…
I am unsure of the impact of this to the regular consumer as this seems like a pretty niche area. But it's kinda shitty that interpersonal relationships of two companies are impacting their customers negatively. The…
It reeks a bit of tech self importance. From an overall business context, you balance time/effort vs short/long term reward and design or fix things when you need to. There are many dials to manipulate in a business to…
So the queen can lay 3 types: hybrid female, Ibiricus male, structor male. Did they do karyotyping? Is it actually that the queen somehow removed its own genetic material from the nuclei or does it somehow get silenced…
The haplotype phasing strategy is the key method here. The phasing method is described in a previous paper: https://www.nature.com/articles/s10038-022-01049-6
I think this sentiment has probably been echoed through the ages. It feels like there's an assumption that we've reached some kind of a complexity ceiling and compressing complexity below us will just make us dumb? What…
It might not be the mainstream on HN, but most popular polls I've seen show similar trends of a lesser proportion of people wanting to live longer, citing the same societal collapse concerns. In any case, whether…
This isn't an unpopular opinion. I would argue this is the mainstream argument. I think all medical advances benefit the wealthy first and then becomes more affordable over time. The term "aging" seems to trigger a lot…
Learning biology is a great insight to how humans think about complex systems. We tend to utilize a reductionist and engineering approach to figure out how things work. This is a perfectly valid approach when building…
I don’t think we are going to agree on this. At the end of the day we are really just disagreeing on how seriously we should take AI-ification of software engineering. I take a lighter stance that it’s mostly harmless…
I wish there was something like LEAN for biology. But there just isn't nearly enough data to build anything close to a good drug discovery simulator. To have a LEAN for drug discovery, we would need to simulate human…
It helps with bureaucracy and pipeline generation. That's valuable and frees up time and effort for scientists. But it's not generating new ideas or solving problems like in math/engineering. The problem is that biology…
Claude will just choose similar toolings as everyone. Orchestration is a really nice tool to have and this can definitely empower non-technical bench biologists. But the bottleneck isn't using the tools or even…
It orchestrated available open source tools to de novo generate and assess the designs. It is still really impressive that it has enough theory to use the tools correctly, but it isn't generating the residues from…
Yeah the calibration is really what makes it useful in practice for quick, small decisions. Asking a LLM to give scores to a problem will yield inconsistently scaled/anchored results that changes at a whim. The blog is…
They are going to run out of real world data very soon. AI labs need to hire non-cynical domain experts to build physical hardware/automation that can generate experimental data. They are hard to find though. Most…
I am getting the exact opposite experience. But it is probably because I am in a domain where code/software is a tool, not the product. I find myself learning exponentially faster and more. For example, I am working…
I don't disagree with Bambu from an operational standpoint, but disagree with their handling of this. They are offering a cloud infrastructure that allows users to remote control the printer via their software. If they…
I have a data science/engineering background. From my perspective, using AI is like mining the solution space for optimality. The solution space is the combinatorics of the billions of parameters and their…
I AI coded an entire platform for my work. It works great for me. I also recognize that this is not something I want to make into a commercial product because it was so easy that there's just no value. I think this…
Yeah this is the simpler and also effective strategy. A lot of people are building sophisticated AST RAG models. But you really just need to ask Claude to generally build a semantic index for each large-ish piece of…
Just write a Claude OS already.
I did this in the beginning and realized I never went back to it. I think we have to learn to embrace the chaos. We can try to place a couple of anchors in the search space by having Claude summarize the code base every…
Were there any discussion from either company about giving government access to consumer data from the the consumer product?
It's a different skillset and way of thinking. Engineers tend to think vertically deep on technical problems. With AI, you have to think horizontally broad and vertically up on the architectural problem. The trick is to…
Pretty cool technique using complementary overhangs and toehold sequences to generate a 3-way heteroduplex, ligate knick, and then remove barcode duplex. They don't give much details on how the barcode duplex is removed…
I am unsure of the impact of this to the regular consumer as this seems like a pretty niche area. But it's kinda shitty that interpersonal relationships of two companies are impacting their customers negatively. The…
It reeks a bit of tech self importance. From an overall business context, you balance time/effort vs short/long term reward and design or fix things when you need to. There are many dials to manipulate in a business to…
So the queen can lay 3 types: hybrid female, Ibiricus male, structor male. Did they do karyotyping? Is it actually that the queen somehow removed its own genetic material from the nuclei or does it somehow get silenced…
The haplotype phasing strategy is the key method here. The phasing method is described in a previous paper: https://www.nature.com/articles/s10038-022-01049-6
I think this sentiment has probably been echoed through the ages. It feels like there's an assumption that we've reached some kind of a complexity ceiling and compressing complexity below us will just make us dumb? What…
It might not be the mainstream on HN, but most popular polls I've seen show similar trends of a lesser proportion of people wanting to live longer, citing the same societal collapse concerns. In any case, whether…
This isn't an unpopular opinion. I would argue this is the mainstream argument. I think all medical advances benefit the wealthy first and then becomes more affordable over time. The term "aging" seems to trigger a lot…
Learning biology is a great insight to how humans think about complex systems. We tend to utilize a reductionist and engineering approach to figure out how things work. This is a perfectly valid approach when building…
I don’t think we are going to agree on this. At the end of the day we are really just disagreeing on how seriously we should take AI-ification of software engineering. I take a lighter stance that it’s mostly harmless…