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tl;dr: "One in 15,000 males is born and grows up as a girl. .. this group is up to 50% larger than previously assumed"
I'm shocked to find out that sex is more complicated than gender identity, and that there might be a bimodal distribution at play. I have been lied to.
> “It is very upsetting for people who have grown up and lived for years believing that they are of a particular sex to suddenly discover that they are actually of the opposite sex. This can be a relief but can also be a loss. For most people it comes as a shock that upends their whole identity. Coping with this can take years,”

I find this statement odd. Haven't we already established that chromosomes do not determine gender? What more is there to cope with beyond a simple genetic abnormality. It's not like discovering this means they suddenly have to register as the opposite gender or use a different bathroom. It's like taking a 13andme test and finding it hard to cope that you're 10% asian.

To be more precise than the headline:

People with disorders of sex development such as Morris or Swyer syndrome have XY chromosomes, but they have female external genitalia, because the sexual development that would normally be triggered by XY chromosomes is somehow suppressed.

Very interesting. Relates to conversations I've had recently regarding trans people in sports. Turns out that conversation isn't simple, because gender is way more complex than the binary M/F options society has tried to act like it is.

Between reasons like in this article, or being born intersex, etc, there are definitely people with female chromosomes who have competed in men's sports, or people with female sex organs and male chromosomes that have competed in female sports. I don't know what the "fairness" answer is, but these are real people.

It's simple

XX division

Unlimited division for everyone else

I know this is a hot button issue but this kind of thinking drives me nuts in general. The number they quote is 1 in 15000. That is an irrelevantly small number and says nothing about the conclusions for the majority of the population. if this was a different issue that wasnt politically charged you would look at the data and conclude the concersation is very simple and there are a bunch of very rare corner cases one needs to be aware of and that would be the end of it.
The headline is rather reductive, presumably to be more provocative. The actual frequency of these conditions is hard to measure for several reasons, but other studies generally do not indicate rates this high.

The headline implies that this singular study from the Danish Cytogenetic Central Registry voids previous studies and takes their place as the new, singular source of truth. That's not how epidemiology works, though, so this study should be considered another data point with associated sampling bias, not a refutation of previous statistics.

These cases are the result of genetic variants, so sampling within a single region (as is the case with this study) can't be extrapolated to the entire population.

This is especially true if you're drunk and a US Marine stationed overseas...
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One in 15k. That suggests that there are roughly 22k females who were born male in the USA.

That is a high enough number that, were they to gather somewhere, you'd notice them, but a low enough number that trying to create laws to give them special treatment is political suicide.