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There is a great podcast with the entire team + Noland on yt. It is ~ 8h long, but IMO it's worth the time. You get to hear things from the perspective of the chief brain surgeon, hardware team, software team, and of course Noland himself. I really recommend it, to get a better understanding of what's possible, what they had to do to get there, and how impactful this kind of research is for people with terrible conditions.
Still the same depraved head of neurosurgery, Dr. Matthew MacDougall, who said: "If tomorrow laws were changed and the FDA said okay you can do some of this early experimentation in willing human participants that would be a very interesting option I think there would be a lot of people that would step up." [1]

That is basically the textbook definition of unethical medical practice, so unquestionably far over the line of acceptable practice that you would have to be willfully ignorant to defend it, and they think it would be exciting if it were not banned.

[1] https://www.youtube.com/watch?v=3ZGItIAUQmI&t=5239s

I love and hate this type of Lex Friedman interviews. Several factors give out when there's a podcast that is posted uncut with a 8 hour length that I'd like to listen to. Wish he cut them!
This tech is incredible but it will be very divisive. Leadership of the current leading company notwithstanding, novel implants such as pacemakers have also undergone a stage of social caution that I would very much expect to surface for brain-interface devices as well, if not more fervently due to an increasing mistrust in technology's utility in our lives.

I am personally hopeful for this technology. I know it will be able to improve the lives of loved ones who both need and want it. I am also afraid of a technology that can decide my thoughts one way or another...

That said, I'll take two.

Divisive is an understatement.

If this tech could be made to work flawlessly, it would be the gate to all the SciFi cyborg stuff, including body enhancements, "telepathy", etc.

Also, as a "side effect", it would open a path to fully immersive VR, as in Matrix, Snow Crash, Neuromancer, etc - with all the upsides and downsides of those scenarios.

All that "just" from hooking up motor and sensor neurons. And then people would probably start and mess with neurons that are involved in cognitive functions and the consciousness.

If generative AI had potential for cultish behavior, I think that will pale in comparison to this stuff.

It killed the vast majority of animals used for testing. Two would probably yield that result for you
I did not see any breakthroughs in neural link patents. Have they solved neural scaring?
Not sure but they did manage to make the patients say that it had changed their lives. :smirk:
There are flexible electrodes, rather than rigid arrays. The idea was that this would reduce scarring. I'm not aware of the exact results of the trials, but it works better than rigid arrays for longevity of recording.
This appears to be at least a partial solve for it.

Older implants are notorious for having that issue - and while scarring doesn't appear to hurt the brain all that much, it sure does hurt the connectivity.

The usual "bed of nails" Utah array typically deteriorates massively within 6 months. Neuralink's very first human implant has lasted for what, a year and a half already? It had issues with dislodged electrodes, which must have hurt the interface quality, but it still remains usable. That's a damn good sign.

so this is like MCP but for neurons?

can they wire up the neurons that control ear twitch muscles to something useful e.g. "Open terminal" shortcut?

>can they wire up the neurons [...] to something useful e.g. "Open terminal" shortcut?

Pretty much. You could do something like that with non-invasive consumer-grade BCIs already though. What we really need to see is more distinct "keypresses" you can listen for. It's my understanding that something like "imagining pushing/pulling a heavy object" can be read clearly enough, while "twitching your left ear" gets lost in the noise.

It's a long way to go before we can replace the 400 keystrokes per minute, 104/105 distinct keys bandwidth of a keyboard.

With the ear twitch muscles, it would probably be easier to use muscle sensors, which are a lot cheaper and easier to use (stick them on the skin), instead of delving inside someone's brain
Have there been any reviews by independent experts? This reads like a promo piece, in particular I'm not sure why the fluff bits about Musk "being a regular guy" are relevant. Most of the linked sources are either other Fortune puff pieces or Neuralink press releases.
Neuralink is amazing technology and watching videos of participants who have completely different abilities and freedom with Neuralink implants is mind blowing. It’s sad that many want to dismiss these amazing achievements just because it’s an Elon Musk founded company. At some point you simply have to acknowledge his success (and his team’s), and hope they get further with all of this.

For those interested in their clinical trials:

https://neuralink.com/trials/

Is it okay to be skeptically appreciative of Neuralink's technological breakthroughs while hoping that, due to its association with Elon, that the technology and talent decides to go elsewhere?

Could be for saltiness over his politics. Could be for skepticism that he can deliver (robotaxi, Mars, etc). Could be for wariness that he'll turn it to shit like USDS, Twitter, and Tesla's finances.

I'd expect that right now it's life changing in a positive way for many recipients.

- The people getting it are in very rough shape and even a tiny bit of improved ability to control their environment is a tremendous gift to them - Musk seems to be busy playing with his other toys - We're far to early in this tech's progress for enshitification to start

Much as I dislike Musk, for the sake of all the people with debilitating conditions that this could help, I wish him phenomenal success with this project.

OTOH, I don't trust him to manage this as a product in an ethical way. What's the DBI equivalent of locking you in a car to drown?

It’s actually the other way around. Musk is getting a ton of attention even for stuff that’s inferior to what other teams are doing.
Everyone who has ever worked in security: “Ain’t no way”.
I’m not convinced this would apply to OpSec people who are physically unable to move any limbs. Pro and cons of course, but..
Yeah, there is a whole interesting story about the Thoratec Heartmate II bloodbpump ("artificial heart") implant and Dick Chaney. Can't be having a back door into the VPs heart implant...
A computer virus that can access brains is a scary thought and I'm not sure what would alleviate that concern for me.

That said, if you need this, the security side of it is a secondary concern to the very immediate quality of life improvement.

I think anyone who chooses to undergo the first few trials of a new operation like this, and is informed about the risks, is very brave. I do not know much of anything about medical science, but my impression is that we are still very, very far from having a deep grasp of how both the brain and the immune system work. Ultimately, to the body an implant is simply a foreign object.

Many tech professionals work on projects that effect people's lives in very serious ways. But a lot of folk seem to feel a bit of meaninglessness in this career and the threshold of making a mistake isn't very high. If it's an off day, sloppy work yesterday can be fixed with another PR.

Building something that is meant to attach to someone's brain would be quite the burden to carry.

> Ultimately, to the body an implant is simply a foreign object.

I get your point but, there's a lot of foreign objects going in by the way of various pores and openings. Biological beings are surprisingly resilient & fragile at the same time.

> would be quite the burden to carry

only if you care

The kind of amount of regulation around this makes me think they are not in that big of a danger, especially as previous devices in this class are way more invasive than Neuralink. I remember that even in their earliest own presentations the width of the "wires" is fraction to previous solutions
Once again, regulation getting in the way of innovation in the name of "safety". Why can't we just sacrifice the vulnerable so I can think messages to my iPhone!
> I think anyone who chooses to undergo the first few trials of a new operation like this, and is informed about the risks, is very brave.

Brave and/or incredibly desperate.

I'll let other blind people go first, but I'm definitely some one that would love, love, love to be able to see. Driving, knowing body language, playing any and every video game out there, shoot yeah!
Why would you not go first? If you are blind it cannot be worse (well it can, but there are always risks).

My wife went through semi-expetimental therapy (at that time) for her MS. It was tough but ultimately a net benefit.

It all depends on what is at stake - I would consider Ozempic for some weight loss but prefer, for now, go for no sugar and moderate portions. This is not life changing for me so I indeed prefer people who will benefit way more from it to go first.

From what I've read, if you are blind from birth, but visual signals were suddenly restored, your brain wouldn't know how to process them. Blind from birth = blind forever. I'm not certain though.
> I'll let other desperate people go first

FTFY.

The exact same comment I would write. Waitin for generation two of any of this kind of tech.
I'm sure it has; and I'm sure it will again, and again, with every single software update.
My son has cerebral palsy, doesn't talk and has poor motor skills. I certainly hope this technology progresses.
I am rooting for success in the general field, but Elon's claims ranging from self-driving cars to autonomous taxi fleets to government cost savings of hundreds of billions need to all be viewed with skepticism. I'll need to see a a lot more than one patient.
The 1-st human that has undergone a partial stroggification?
Once the technology is replicated and perfected by somebody outside of Neuralink. I would potentially consider it. Also, the entire technology landscape would need to be changed.

I don't want brain implants to be owned by the wealthy, as it currently exists. Elon Musk and PR team can fuck off.

I think that the negativity here is unfortunate. The reality is that it’s very hard to see a normal VC level return on the $100M+ Elon and friends have invested here. And don’t let anyone fool you - this is the fundamental reason the BCI field has moved slowly.

If Neuralink proceeds to a scenario where quadriplegic patients can get reliable (ie lifelong) control of their computers for less than $100k that will be a huge win for them for a cost that no one else was willing to pay.

To be clear, at that order of magnitude they might make back their investment, but it won’t be 10x or 100x, and the potential healthy-brain-connected-to-the-AI play is much less rooted in reality than Teslas all becoming taxis.

Worst case scenario is that Elon loses interest and pulls the plug and Mr Arbaugh loses continued tech support a la a google product. I think that’s the one question I wish the author had asked…

VCs don't actually like risk, and can't distinguish snake-oil from groundbreaking inventions - more news at 11
Don’t forget, we are currently running “Elon is bad” narrative.

Apparently, many people listen.

Too much marketing speak without the demo. I have read this long article and did read some more related content on the internet, so let me summarize it for you.

With Neuralink,

- Noland can control cursor of his computer - He can schedule calendar meetings - He can control his purifier, television, etc. - He can play games like mario kart

I could only find this demo on the internet where Noland plays chess - https://x.com/i/broadcasts/1ypJdkXjaLNGW

There's a lot of both negativity and positivity here. I think both are warranted and important. I'm not generally a fan of Musk and think most of his ventures are overhyped. I also understand that Neuralink committed a series of horrific acts against macaques to develop this device and they ought to be investigated and have what they did shown to the public for scrutiny.

That said, as someone who has undergone screening for a neurodegenerative disease (thankfully I tested negative), I'm fairly confident in saying that it's an awful thing to experience and any technology that can provide more autonomy is invaluable. When I had to confront the possibility that I might have MS or ALS, I literally said "Neuralink probably shouldn't have killed those monkeys but, fuck it, they're already dead so they better hurry up. I don't want to live like that."

I hope we can develop further treatments more ethically and in a way that doesn't result in dystopian brain adverts of course, but even this level of technology is miraculous.

Love to see it. Wonder if Neuralink ever comes up with less invasive tech that could be used for fun like Emotiv EPOC, but even if they don't, maybe getting one implanted will be as normal as getting a tattoo or a piercing give some years. Because I see this being desirable for "normal" people pretty much already!
>it seems to me that only science, aided by human decency, common sense, farsightedness, and concern for the unfortunate and the poor, offers the world any hope in its present morass.

Oliver Sachs