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Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory gene, IGF2, through targeted DNA methylation editing. These findings highlight that aging brains can regain function through precise molecular intervention.
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"In mice", I thought to myself. But then I read the article - and how wrong I was!
Looking forward to seeing the same generation of biohackers who previously CRISPRed their lactose intolerance to now CRISPR their hippocampi!
Funny how nobody has used CRISPR to make the body naturally produce caffeine…
I don't necessarily want to live forever, but god I would love to have a quick brain for the rest of my life.
It’s about our quality of life.. not about longevity.
With my luck it'd replay that one time I did the stupid thing in high school more frequently.
Not with regard to the acute mental decline of Alz or dementia, which seemingly are a lot of trauma for many involved, but perhaps there is some adaptive function to slight memory loss with aging? Maybe old people don't want to remember everything? Idk.

If reincarnation is real, that involves a total memory loss at the terminal age limit, so that is somehow adaptive, allowing a new growth of life. Maybe slight memory loss in the aged allows a refresh or new growth of life. A sort of lightening of the burden, perhaps? To let the aged evolve into a new phase of life? Letting go of the past?

There could be something to that. The wisdom of the elderly may be related to an ability of such pruning to permit sight of the forest for the trees, the gaining of perspective.

My aunt suffers from memory loss. I sincerely hope breakthroughs like this can make a real difference soon.
Whenever I see these articles on HN, I'm now primed into thinking "it means rats brains" and I'm usually right. I truly appreciate the research in this and other fields (e.g. Alzheimer), but clickbait titles like those give false hopes to readers who may have friends or relatives suffering from real conditions. Please make it clear that we're talking about _rats_ and it may take years for those researches to be available to us _human beings_.
Basically a state that is believed to be a "good state", and anything outside of that state is a "bad state". Its like changing the air filter on a car when it's not running right, but it just happened to need an air filter but the real problem is the fuel injector and the rubber hoses deteriorating.
I guess in 10 years I'll forget to check whether they are at a phase 1 trial.