Sleep is Lindy... obesity and constant wakefulness are not.
The sad fact is that people will be pressured into taking this.
E: Lindy was probably the wrong term. But still, it's like Chesterton's fence. We are far from fully understanding human biology... and deleting sleep will lead to unknown effects. All power to those who try, I guess.
It sounds to me like something that's quite dangerious. Maybe it helps people with narcolepsy but maybe it will be another thing people abuse like amphetamines?
Not to take away from the broader point, but modafinil is lumped in with methylphenidate as a stimulant that "increase[s] the activity of neurotransmitters such as dopamine and norepinephrine". Modafinil does also stimulate the orexin system and is part of why it's so effective for wakefulness and not as a stimulant in the medium/long-term.
The article is about modulating orexins in the brain. Orexin receptor agonism was thought to be a mechanism of modafinil/armodafinil but this isn't mentioned anywhere in the article. Modafinil is mentioned as a mere stimulant. It sort of makes me want to dismiss the article as manufactured hype for a new class of modafinil successors.
I think the real question with Ozempic is.....why are so many people's bodies not producing enough natural GLP-1 in the first place?
Ozempic is for sure a miracle for some who really need it but for many I think they would be better off by solving that problem at the source (likely gut bacteria based and consuming a better mix of prebiotic fibers). Increase your natural levels of GLP-1
As an aside, are there any habitual modafinil takers here? I had a period in college where I took it very rarely when I had to cram. Worked pretty well.
Imagine a cure for sleep, it would be a big productivity gain for society if people could work way more hours or spend more hours consuming every day and not even be tired.
I just want something that increases deep sleep -- I think just tricking the brain to control sleep is probably not enough -- it's likely a two way street.
"Ozempic moment" seems like a manufactured buzzword in this context. A new modafinil variant is nothing like Ozempic. The thing that was actually interesting about Ozempic wasn't its windfall profits, it was the fact that it is a new class of drugs, and the fact that it's able to rather directly target a habit without wreaking havoc on the body. Part of the article mentions there is hope it may be useful for depression, ADHD, and addiction, but whether any of this is actually actually effective is up in the air. Lots of things are in "pharmaceutical companies hope it can treat mental illness" status... but trying to cast an image of being on the verge of a breakthrough is big pharma's whole marketing.
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[ 29.8 ms ] story [ 96.2 ms ] threadThe sad fact is that people will be pressured into taking this.
E: Lindy was probably the wrong term. But still, it's like Chesterton's fence. We are far from fully understanding human biology... and deleting sleep will lead to unknown effects. All power to those who try, I guess.
FTFY
If I'm not mistaken there was an experiment using fruit flies where they fed them antioxidants and that made them not die from lack of sleep.
The article seems to imply this is not the case. Do you have a source that says that Orexin agonism is the mechanism of action for modafinil?
Ozempic is for sure a miracle for some who really need it but for many I think they would be better off by solving that problem at the source (likely gut bacteria based and consuming a better mix of prebiotic fibers). Increase your natural levels of GLP-1
- Ozempic For Sleep https://www.isaak.net/sleepless/ (November 2024)
It is the same author from https://news.ycombinator.com/item?id=41742432
He recently founded https://capable.com, also related