The weirdest thing I read about was weightlifters taking viagra to increase their blood flow when working out at the gym. Hopefully they shower at home.
cancer is a big word, arimidex is just an aromatase inhibitor that prevents androgens from turning into estrogen, that also helps prevent spread of some types of cancer. Amazon is full of turkey tail supplements, that's also a prescription cancer medicine in Japan
Suprised this article doesn't mention nitric oxide or vasodilation? Is that how it works. It boosts nitric oxide signaling, acts as a vasodilator, and improves endothelial function. Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.
As usual, without double blind studies, this is playing with fire… maybe the people taking have better health because of the extra exercise that goes with an active sex life.
I would imagine the sex itself isn’t super relevant in terms of exercise. But people who seek out medical treatment (or enhancement) likely take better care of themselves in general.
But I would be surprised if there were not a measurable increase in health markers for men who take Cialis. Pretty much any drug that reduces blood pressure is going to have a positive effect on longevity for the average male population (but not the sub-population who have low blood pressure).
>people who seek out medical treatment (or enhancement) likely take better care of themselves in general.
That was immediately my thought as well, the population of men who seek out ED medications have to be very distinctly different than the population of men in general.
Fascinating! I have non-hearing damage induced Tinnitus and Bipolar Disorder and have been interesting in my PDE genetics for sometime as a link to my issues. It seems I have a natural inhibition of many PDE genes (PDE4B specifically, but I have some less studied changes in my PDE5A genetics which suggests an inhibition there as well).
Sildenafil has been know to make BP people relapse in one case...
Also avoid things that increase blood pressure and do more thing that improve your cardiovascular system. No amount of drug will make up for decades of abuse
Very interesting. Since you've spent some time thinking about it, what's your hypothesis of the connection between high blood pressure and dementia? Any interesting links you could share?
Maybe high blood pressure causing more pressure in the blood vessels of the brain, leading to a lifetime or decades of cumulative damage?
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[ 29.9 ms ] story [ 1660 ms ] threadTadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor.
Help to live longer was the main objective since the beginning.
[0] https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History
https://www.webmd.com/vitamins-supplements/l-citrulline#uses
Add deep breathing to that list too, believe it or not!
But I would be surprised if there were not a measurable increase in health markers for men who take Cialis. Pretty much any drug that reduces blood pressure is going to have a positive effect on longevity for the average male population (but not the sub-population who have low blood pressure).
That was immediately my thought as well, the population of men who seek out ED medications have to be very distinctly different than the population of men in general.
Thus this very well might be a yardstick, not an actual benefit.
Sildenafil has been know to make BP people relapse in one case...
https://academic.oup.com/ijnp/article/7/4/525/707950?login=f...
And also investigated with some mood issues...
https://link.springer.com/article/10.1007/s00213-023-06361-3
Zinc and Magnesium are cofactors for all the PDE genes and those have helped me, specifically the zinc.
I have a feeling that low GTP is causing issues in ED since Cyclic GMP is made from GTP.
Every time I read about a drug reducing dementia risk or increasing longevity I look it up to see if it lowers blood pressure. Never fails.
Cialis does.
Also avoid things that increase blood pressure and do more thing that improve your cardiovascular system. No amount of drug will make up for decades of abuse
Maybe high blood pressure causing more pressure in the blood vessels of the brain, leading to a lifetime or decades of cumulative damage?
OTOOH, I take beet juice powder, which is to increase blood flow pre-run, so I would not be surprised if folks “leveled up” to a pharmaceutical.