Well I never said I thought it was going to work in the long run. However, most revenue comes from business API use. I could certainly imagine some kind of legislation that makes it much harder for businesses to…
My read is that OpenAI & Anthropic have realized they are reaching model capabilities that cannot be monetized due to various risks. E.g., an engineer deploys an agent over the weekend that decides, when stuck on a…
Current evolved Cas9 (CRISPR) variants are highly efficient and relatively unconstrained in terms of their human genome targeting coverage. Smaller nucleases and higher targeting specificity would be useful. But…
I dont disagree. Clearly AI leans on the cumulative cognitive labor of humanity without porpper attribution. This is in part due to the design of these sytems. Information is compressed into the weightspace in ways we…
We're at a point where I assume that whatever I read is something the "author" endorses, but may not have written. And that may be more important than the specific words an author may have chosen themselves. I doubt we…
Mathematicians insist that in many cases the route toward solving a problem is more valuable than solving the problem itself. This may have been true, and may still be true for now, but this seems to implicitly assume…
Isnt the sensory grounding even in abstract cases some (limited) intuition that simulates in a mental world model?
I wonder, how does distillation deal with unprobed spaces in the knowledge landscape? Is a distilled model worse in some niche area that was not probed? Presumably, this is why frontier labs dont distill their own…
I wonder how much of the sloppy feeling is created by the knowledge that its AI generated.
Accelerationists may argue that the eroding of proper attribution and proof verification by humans is a meaningless short term struggle of a dying field. Mathematics seems to be entering an era where human + machine…
If you take the ambitions of robotics and AI companies seriously then what they are trying to create is the equivalent of unleashing 100 million cloned copies of the smartest and most well adjusted people you know upon…
Couldn't Google just do it better though?
I'm a genetic engineer at a large pharma company. We corrected the HTT gene in patient derived iPSCs in the lab. The region is a long repeat sequence of which a section needs to be deleted. Because of this the locus is…
One would probably engineer these cells with a killswitch, such as doxycycline induced Caspase9 https://pmc.ncbi.nlm.nih.gov/articles/PMC1895037/. The transgene engineering is totally possible without a viral vector. We…
Let me clarify that I dont think any of what I described is a given. I think its one of the more likely outcomes of our future. I think its prudent to own a small amount of Bitcoin (or basket of cryptocurrencies) in…
Bitcoin is the only immutable peer to peer system ever created (barring advances in quantum computing, and even then the protocol can be updated). In a world headed toward web 3.0, generative AI content & virtual…
I added my credentials to address the "malicious scientist" scenario that some people may associate with leaked genetic information. You dont need an individual's genome to create rather dangerous gentic weaponry. For…
The impact of lifestyle is undeniable and large. Good genes will not protect your body from alcoholism. And if I were a betting man, I would bet against determinism emerging from a better understanding of combinatorial…
We are on the cusp of being able to plow through vast quantities of literature and data in an instant using multimodal machine learning models. Journal articles are written for people. The landscape is changing. We are…
[flagged]
Randomness just introduces branch points into the linear flow of deterministic states. Since you do not control the branch points or create them, this does not give you free will.
There is only so much that you can get out of tinkering with naturally evolved proteins. I suspect that these kind of tools can be used to generate smaller & brighter FP's in the near future.
Very nice work. We need brighter fluorescent protein tags that are more compact, in particular in the far red spectrum. The size of current fluorescent protein coding DNA sequences is out of reach of prime editing and…
Well I never said I thought it was going to work in the long run. However, most revenue comes from business API use. I could certainly imagine some kind of legislation that makes it much harder for businesses to…
My read is that OpenAI & Anthropic have realized they are reaching model capabilities that cannot be monetized due to various risks. E.g., an engineer deploys an agent over the weekend that decides, when stuck on a…
Current evolved Cas9 (CRISPR) variants are highly efficient and relatively unconstrained in terms of their human genome targeting coverage. Smaller nucleases and higher targeting specificity would be useful. But…
I dont disagree. Clearly AI leans on the cumulative cognitive labor of humanity without porpper attribution. This is in part due to the design of these sytems. Information is compressed into the weightspace in ways we…
We're at a point where I assume that whatever I read is something the "author" endorses, but may not have written. And that may be more important than the specific words an author may have chosen themselves. I doubt we…
Mathematicians insist that in many cases the route toward solving a problem is more valuable than solving the problem itself. This may have been true, and may still be true for now, but this seems to implicitly assume…
Isnt the sensory grounding even in abstract cases some (limited) intuition that simulates in a mental world model?
I wonder, how does distillation deal with unprobed spaces in the knowledge landscape? Is a distilled model worse in some niche area that was not probed? Presumably, this is why frontier labs dont distill their own…
I wonder how much of the sloppy feeling is created by the knowledge that its AI generated.
Accelerationists may argue that the eroding of proper attribution and proof verification by humans is a meaningless short term struggle of a dying field. Mathematics seems to be entering an era where human + machine…
Accelerationists may argue that the eroding of proper attribution and proof verification by humans is a meaningless short term struggle of a dying field. Mathematics seems to be entering an era where human + machine…
If you take the ambitions of robotics and AI companies seriously then what they are trying to create is the equivalent of unleashing 100 million cloned copies of the smartest and most well adjusted people you know upon…
Couldn't Google just do it better though?
I'm a genetic engineer at a large pharma company. We corrected the HTT gene in patient derived iPSCs in the lab. The region is a long repeat sequence of which a section needs to be deleted. Because of this the locus is…
One would probably engineer these cells with a killswitch, such as doxycycline induced Caspase9 https://pmc.ncbi.nlm.nih.gov/articles/PMC1895037/. The transgene engineering is totally possible without a viral vector. We…
Let me clarify that I dont think any of what I described is a given. I think its one of the more likely outcomes of our future. I think its prudent to own a small amount of Bitcoin (or basket of cryptocurrencies) in…
Bitcoin is the only immutable peer to peer system ever created (barring advances in quantum computing, and even then the protocol can be updated). In a world headed toward web 3.0, generative AI content & virtual…
I added my credentials to address the "malicious scientist" scenario that some people may associate with leaked genetic information. You dont need an individual's genome to create rather dangerous gentic weaponry. For…
The impact of lifestyle is undeniable and large. Good genes will not protect your body from alcoholism. And if I were a betting man, I would bet against determinism emerging from a better understanding of combinatorial…
We are on the cusp of being able to plow through vast quantities of literature and data in an instant using multimodal machine learning models. Journal articles are written for people. The landscape is changing. We are…
We are on the cusp of being able to plow through vast quantities of literature and data in an instant using multimodal machine learning models. Journal articles are written for people. The landscape is changing. We are…
[flagged]
Randomness just introduces branch points into the linear flow of deterministic states. Since you do not control the branch points or create them, this does not give you free will.
There is only so much that you can get out of tinkering with naturally evolved proteins. I suspect that these kind of tools can be used to generate smaller & brighter FP's in the near future.
Very nice work. We need brighter fluorescent protein tags that are more compact, in particular in the far red spectrum. The size of current fluorescent protein coding DNA sequences is out of reach of prime editing and…