The Smith chart is the electrical engineer's favorite: https://en.wikipedia.org/wiki/Smith_chart You either love it or hate it, depending on how well your electromagnetics class was taught.
Unpaywalled: https://archive.is/dmp0m
The cynical part of me wonders: if this has been a promising approach for 10+ years, why weren't they able to secure VC funding years ago (or nonprofit biomedical research funding from places like the Gates Foundation…
Thanks for the response! This is very cool and sounds like a reasonable plan. Best of luck!
I am totally onboard with the premise (as a TechBio-adjacent person), and some of the approaches you're taking (focused domain-specific models like Orthrus, rather than massive foundation models like Evo2). I'm curious…
There are biotech companies like Eikon Therapeutics (https://www.eikontx.com/ ) where super-resolution microscopy in living cells is a central part of the platform. There is also one widespread approach that isn't…
A thread from yesterday about why gene therapy hasn't reached its potential: https://news.ycombinator.com/item?id=44573193
DeepMind/Google does a lot more than the other places that most HN readers would think about first (Amazon, Meta, etc). But there is a lot of excellent work with equal ambition and scale happening in pharma and biotech,…
Very cool. There are also methods that allow you to extract some notion of motion from variability in CryoEM data, e.g. CryoDRGN-ET [1]. I'm curious if you've worked with any of those models and how they relate to NMR…
thought this was about tracing neural circuits in the brain and was disappointed.
Detailed New England Journal of Medicine article about this case: https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 And an Editorial piece (more technical than the NYT):…
It is possible that they are licensing technology that was developed in academic science and are raising money to scale it up and get it ultra-standarized for commercial scale. I agree that the modern Silicon Valley…
Indeed, now is the moment to step on the gas in biotech. The past 15 years have been nothing short of extraordinary in the field. We finally have the tools needed to effectively measure biology, manipulate biology, and…
It is worth mentioning that China is heavily investing in biotechnology and they are getting genuinely good at the more commodified parts of the industry. This blog post [1] is long and aimed at a biotech expert…
Lots of biotech companies are working on immunosuppressant-free islet-equivalent transplantation. Two examples off the top of my head: Sana recently announced islet cell transplantation without immunosuppression (press…
1) Creative projects beget creative projects. When you start working on one project, you'll have ideas for a dozen more, and probably one of those might actually be a good project idea to continue exploring and refining…
I am pretty sure that the CGP Grey video was the core inspiration for this article. Nearly every image in the article was featured in the YouTube video, which predates the article by ~4 years.
Have you looked into Nebula Genomics? They will do 30X coverage WGS for $299, and will give you the underlying data so you can analyze it on your own (in addition to their analyses). Link:…
Nebula Genomics: https://nebula.org/whole-genome-sequencing/
I would recommend the edX Introduction to Biology course [0]. It is a simplified version of the introductory biology course at MIT, that doesn't _focus_ on naming/defining things in biology. Instead, it uses the lenses…
The Vital Question, by Nick Lane is a pretty good book that takes a thermodynamics first approach to this question.
Mostly agreed. In my eyes, the takeaway from this piece is not that neuroscience is futile and that we should give up, but rather that we now should redouble efforts on analysis methods to make sense of the large,…
The stories in this piece really highlight the importance of having these tough conversations with family members about what you want to happen for your own medical care if the worst happened. I really enjoyed Being…
On the topic of describing the events of the code (cardiopulmonary resuscitation) in great detail, there have been studies showing that bringing the family into the room during a code leads to decreased PTSD for the…
Grape juice is the notorious one here. It doesn't have a very strong taste on its own, so when blended basically serves as a not-technically-added-sugar source of added sugar.
The Smith chart is the electrical engineer's favorite: https://en.wikipedia.org/wiki/Smith_chart You either love it or hate it, depending on how well your electromagnetics class was taught.
Unpaywalled: https://archive.is/dmp0m
The cynical part of me wonders: if this has been a promising approach for 10+ years, why weren't they able to secure VC funding years ago (or nonprofit biomedical research funding from places like the Gates Foundation…
Thanks for the response! This is very cool and sounds like a reasonable plan. Best of luck!
I am totally onboard with the premise (as a TechBio-adjacent person), and some of the approaches you're taking (focused domain-specific models like Orthrus, rather than massive foundation models like Evo2). I'm curious…
There are biotech companies like Eikon Therapeutics (https://www.eikontx.com/ ) where super-resolution microscopy in living cells is a central part of the platform. There is also one widespread approach that isn't…
A thread from yesterday about why gene therapy hasn't reached its potential: https://news.ycombinator.com/item?id=44573193
DeepMind/Google does a lot more than the other places that most HN readers would think about first (Amazon, Meta, etc). But there is a lot of excellent work with equal ambition and scale happening in pharma and biotech,…
Very cool. There are also methods that allow you to extract some notion of motion from variability in CryoEM data, e.g. CryoDRGN-ET [1]. I'm curious if you've worked with any of those models and how they relate to NMR…
thought this was about tracing neural circuits in the brain and was disappointed.
Detailed New England Journal of Medicine article about this case: https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 And an Editorial piece (more technical than the NYT):…
It is possible that they are licensing technology that was developed in academic science and are raising money to scale it up and get it ultra-standarized for commercial scale. I agree that the modern Silicon Valley…
Indeed, now is the moment to step on the gas in biotech. The past 15 years have been nothing short of extraordinary in the field. We finally have the tools needed to effectively measure biology, manipulate biology, and…
It is worth mentioning that China is heavily investing in biotechnology and they are getting genuinely good at the more commodified parts of the industry. This blog post [1] is long and aimed at a biotech expert…
Lots of biotech companies are working on immunosuppressant-free islet-equivalent transplantation. Two examples off the top of my head: Sana recently announced islet cell transplantation without immunosuppression (press…
1) Creative projects beget creative projects. When you start working on one project, you'll have ideas for a dozen more, and probably one of those might actually be a good project idea to continue exploring and refining…
I am pretty sure that the CGP Grey video was the core inspiration for this article. Nearly every image in the article was featured in the YouTube video, which predates the article by ~4 years.
Have you looked into Nebula Genomics? They will do 30X coverage WGS for $299, and will give you the underlying data so you can analyze it on your own (in addition to their analyses). Link:…
Nebula Genomics: https://nebula.org/whole-genome-sequencing/
I would recommend the edX Introduction to Biology course [0]. It is a simplified version of the introductory biology course at MIT, that doesn't _focus_ on naming/defining things in biology. Instead, it uses the lenses…
The Vital Question, by Nick Lane is a pretty good book that takes a thermodynamics first approach to this question.
Mostly agreed. In my eyes, the takeaway from this piece is not that neuroscience is futile and that we should give up, but rather that we now should redouble efforts on analysis methods to make sense of the large,…
The stories in this piece really highlight the importance of having these tough conversations with family members about what you want to happen for your own medical care if the worst happened. I really enjoyed Being…
On the topic of describing the events of the code (cardiopulmonary resuscitation) in great detail, there have been studies showing that bringing the family into the room during a code leads to decreased PTSD for the…
Grape juice is the notorious one here. It doesn't have a very strong taste on its own, so when blended basically serves as a not-technically-added-sugar source of added sugar.