Russell manages to give a laugh at even the most disturbing topics. Here is is his show about the huge industry of blood extraction. https://youtu.be/82pOL361zUk
Russell is using conspiratorial populist fear mongering to pivot into a new career. "Big Pharma Billionare Politician pedophile boogeyman don't want you to know they're coming to get you"
this above article is kind of inflammatory, however, this paper is incredibly interesting.
I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mechanism to moving factors that will cause up regulation, etc, is very novel.
honestly one of my favourite papers in the last five years, I am obsessed.
Modifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers.
A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pills and injections are perpetually 5 years out.
I'm aware of at least one that was able to halt or reverse alzheimers in a 200 patient trial, but folded after they couldnt get funding to move forward.
sorry! maybe it's just my thoughts on the matter that have changed. i understand that you can have drugs move through the glymphatic system, but maybe i was just unaware that you can move a whole host of other cell proliferation factors through the glymphatic system also!
To be clear I was talking about a drug that increase the fluid movement rate/duration/frequency of the glymphatic filtering, which allow to improve the quantity of cleaning.
If you're talking about the effect of the glymphatic system on the repartition of Neurotrophics, I have no idea :)
There's a fair bit of literature suggesting that there's more to it than the production rate. Metabolite delivery and removal also depends on the dynamic pressure and frequency response of the system. That is to say, to get the appropriate pulsatile flow the brain can't be too rigid or too flaccid
This is one that I thought was compelling.[1] The trial ultimately failed but if you read the results the post-hoc analysis, it showed promise in mild and moderate subgroups of the ITT population. Most drugs today don't even target mild AD, but go after pre-symptomatic patients.
There was also benefit across most measures, but just not of statistical significance.
The trial had some major problems with appropriate controls, and is widely cited as a poster child for why the FDA should not require a control group to undergo invasive brain-surgery, and how this can taint the results.
It also showed a 89% reduction in amyloid Beta, the same proxy measure Biogen's aducanumab was recently approved based on.
Thanks for checking. Alzheimer Management By Albumin Replacement (AMBAR) treatment has shown efficacy in slowing the progression of moderate & advanced stages disease [0, 1].
Yeah, is totally absurd that given the health care and social cost of of Alzheimer's we're not taking Broad shotgun approach to investigating potential remedies.
There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.
yes yes I know that increasing CSF flow is not that novel (anymore e.g. last couple of years). you can increase it with cerebral blood flow, and you can do this with sleep, respiration, visual stimuli, etc.
however, the ideas of 1) replacing csf from young to older mice and 2) the idea that there are factors in CSF that are being delivered to other areas of the brain and promoting cell proliferation: that's pretty novel.
all of the literature right now points to csf in terms of waste clearance and csf is painted as almost a river that picks up components and moves waste (e.g. amyloid beta) from the periarterial areas in the parenchyma and then out through the perivenous areas into the lymphatic system. and this means that the idea of delivery of promoting factors is really interesting.
In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.
Not quite the same, but there exists a nootrooic called Cerebrolysin which is made from enzymatically treated pig brain peptides, including all sorts of brain growth factors.
I wonder if taking something with brain growth factors makes you more or less likely to suffer from more serious consequences if you have brain trauma. ie Are you more or less likely to have a serious concussion after hitting your head.
I cannot answer your question but growth factors are extremely effective after a concussion/AVC/TBI/stroke.
People and doctors are extremely uneducated and therefore people that have TBI will have high persistent damage. The truth is, most of the damage is generally not done during the trauma, but during the weeks/month following it.. And those damages can be for the most part prevented by taking protectors, which as I said, isn't done in practice because science bad
Generally speaking, brain growth factors are protective against and regenerative of brain damage/atrophy. You could call them pro-neuronal-function factors.
This makes me wonder about transmission of diseases such as prions in that kind of transfusion though. Perhaps better to understand the fundamental process and synthesize the core chemicals involved (if it comes to that).
It is so frustrating that the end result is years away. I hope that they don’t just look for some equivalent micro drug but perform experiments with the actual growth factor in human test subjects.
Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results.
Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it?
I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session?
Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.
My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf.
It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
It is that simple to some extent, recycling and resource control is a major factor in aging.
Targets:
Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin.
The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators.
BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
https://mitolab.com/product/vismotech-skq1-bromide-solution-...
You should always coadminister (take at the same time or a bit before) NAC (600mg+)
SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process.
Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect.
I don't understand why dilluting it would work here - either its filterable and it would get filtered regardless (e.g. drinking water would be enough) or it wont be and the dillutant would just be filtered
A personal experience that comes to mind is when my childhood cat developed kidney disease.
She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
I had a cat when I was in my 20s that got into a fight some eve...
Its face got infected and blew up. It was $8,000 for surgery, and I couldnt afford it - so had to put her down... but I did love that cat, and I would have paid it if I had it...
Pet insurances are very useful for such situations. They cover you for big surgeries and make those small procedures almost invisible in your monthly budgets.
My cat had (likely) something similar and needed to regularly be given subcutaneous saline fluid. He learned pretty quick to associate me stabbing him, with him feeling better. That kind of thing becomes easy once you get into the routine.
You've jogged my memory, it was subcutaneous not intravenous for my childhood cat as well. The saline would form a bulge under the skin before diffusing into the body. It wasn't something I did myself, we were bringing our cat to the vet to have it done until my parents tired of it.
Honestly I don't really know what all was checked. We brought her into the vet when she wasn't eating and behaving lethargically, they said her kidneys were failing and we'd have to bring her in regularly for saline bags or learn to administer them ourselves.
I believe there are good health reasons to donate. I forget the details, but it stimulates positive processes in the body. I think the effect is marginal, but it's nice to know you get a small personal bonus from doing something nice for other people.
I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.
But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.
That doesn't seem right. Sperm and eggs are created by cell division too. In some sense you come from a line of cells that extends long before your birth. If cell division "wore out" after some number of divides you should be already worn out.
I've seen the claim that the correlation between increasing paternal age and the incidence of various congenital disorders has exactly this etiology.
I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might not be a surprise to see it demonstrated that the cause is in fact the accumulation of errors in the genome that's half-duplicated during spermatogenesis.
Regardless - at some point "you" (or cells and genetic information that would become you) were an egg. At some point that egg was an egg, and that egg was an egg, and so on all the way up n generations to asexual and single celled organisms.
Well yeah, but if complex self-replicating organisms aren't also very good at self-repairing, they don't self-replicate very long.
Individuals do get less good at it over time, though. The structures described earlier as "shortening" are called telomeres [1], and they do actually do that, as a result of DNA copying being a physically somewhat destructive process. They're purely structural rather than informatic, though, and everyone starts out with a fresh set.
Not just congenital disorders, but mental health disorders as well. It's been known for a while that paternal age is a risk factor for schizophrenia.
I had an internship at the New York State Psychiatric Institute (before I moved into software development). Paternal age was used as one factor in determining if people were at risk for psychotic breaks (schizophrenic prodromes) by one of the assessment tools they developed.
I only need to live long enough for one form of eternal life to transpire. Cyborg body, brain transplant to a clone, reversal of aging. I don't mind helping out others while I wait :-)
A while ago I read about marrow donation. Turns out I had all kinds of misconceptions (thought it waa invasive and painful). I'll definitely try to donate when I get my health back in order.
It was not enjoyable, but I'd do it again. The emotional side of it was way more difficult than the physical side. I'd recommend getting benzos for the actual donation day.
May be a stupid question but how confident are we that we understand memory in mice? Is memory as humans perceive it the same as what mice perceive it?
you can classify memory into many different components, and how memory in mice translates into humans is not extremely clear.
we can do experiments that do fear conditioning, or classic conditioning and operant conditioning, but the translation from mice to humans is definitely not clear cut. I think this is one of the biggest weaknesses of the paper actually
We do not understand memory of humans nor of mices nor of C.elegans. The question of the neural code is an unsolved problem with close to zero progress.
However we don't need to,
The regions and deficits in memory processing are highly preserved/correlated between mammals.
They are many potent Nootropics for memory, such as Dihexa and prl, those are called hypermnesics.
A classical one is choline, found in eggs and overlap with the nicotine impact on intelligence
> My Stem Cells My Choice
We need a political movement
Strong agree but I'm not aware wether adult stem cells can be grown into whole organs.
It's true that e.g the spleen can respawn after ablation so definitely not impossible.
Although of course the graal is your sperm, it is a DNA that is 0 years old, you can't make it any younger! Growing fœtuses without brains might be a real possibility and the ultimate medecine breakthrough.
Note that your eyeball metabolism can be significantly rejuvenated, e.g retinalamin often reverse blindness in humans. Or Skq1/visomiten. Glaucoma and macular degeneration are totally solved problems.
As for myself I want to shrink my eyeballs (myopia) but this is not pharmacologically doable (because extremely undefunded) although Berberine do very significantly slow the myopia progress.
These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.
This is why the SV billionaires need to create the metaverse. The matrix had a the right idea, just keep the young plugged in to VR and use machines to do the dirty work.
I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people? We just saw the Jeffrey Epstein thing unfold, and who-knows what well-connected old-money/old-power folks were serviced by him and Ghislaine Maxwell. If they could extend their life and get their pickings of young girls, you bet they'd do it.
This old-eating-the-young thing has been going on for time immemorial. It's encoded into our mythology, of Saturn eating his children so that they wouldn't usurp him. And it's not just our (i.e. Western) culture either.
> I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people?
No, It’s because Peter Thiel was (perhaps still is) reportedly interested in it, and that was a big enough story to be eventually lampooned by the comedy show Silicon Valley.
Death is the ultimate equalizer. We take solace in the fact that no matter how rich, brutal, tyrannical, comically-villainous one is, death will surely come for us all.
The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
I think it's the exact opposite. The day being old is no longer a disease and a path to inevitable death will be one of the greatest things to ever happen to humanity, now and forever into the future. Especially if you can retain a youthful, healthy brain and body no matter how old you are.
An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.
Pretty sure the possible world being lamented in the GP comment is not "everyone gets to live forever and stay healthy and youthful" but instead "there exist expensive, parasitic procedures which will allow some rich people to have drastically extended lifespans."
You can be almost sure that once the underlying mechanism is known, the necessary stuff will be synthetised instead of being transferred from a young person to an older one. If only to guarantee stable supply, consistent quality and rule out accidental transmission of various pathogens from the donor.
As a computer i find your trust in technology amusing.
The underlying mechanism of a heart, for example, is known. But they still search for pigs to take hearts for transplant.
I dunno, we understand the underlying mechanism of blood pretty well, but we’re still a long way off from being able to (economically) synthesize blood for transfusion.
An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.
Tyrants aren't even forever even if they never die of old age. After all, tyrants can meet their end through constantly replacing their followers with yes-men to the point of becoming increasingly detached from reality. This may prevent them from noticing certain features of reality such as military incompetence of their force.
All I can say is I wholeheartedly disagree. It has some pragmatic utility in replacing stale, antiquated ideologies, but the costs vastly outweigh the benefits, and there are always future solutions that can help retain such things to a degree: e.g. you can no longer vote or run for office if you're above the age of 110, or whatever.
Death is just a thing that happens. Whether it is horrible, sad, a relief or a reason to celebrate depends on whom you ask about whose death at which point in time.
The suicide of Hitler certainly was a horrible tragedy to his close family and those who believed into him — for many others it was a reason to celebrate. Similarily death of a young family member can be traumatic to the max, while the death of grandmother which everybody (including herself) already accepted and comes after a live well lived can be even have a certain beauty to it.
For me, death is not the main problem, but the long, drawn out period of slowly coming apart definitely is. I would very much prefer not to spend last 15 years of my life crippled from multiple degenerative diseases of old age.
Most of the longevity research is trying to stretch healthspan. Stretching lifespan as such is a nice side effect.
Having watched my mum, and now my dad decline in old age I couldn't agree more.
I don't like the idea of dying, but the slow slide into immobile sinility is positively terrifying.
I'm in my 40s. I've resolved to look after my health not to live longer, but to extend my health for as long as possible. I'm determined to stay active, mobile and socially/intelectually engaged for as long as I can, partly for my self, but also for my kids.
Huge worry for me as well. Let me remind everyone that aging is mostly about entropy, the exact same thing that causes an engine to inevitably wear out and break down happening to you and just like an engine fixing can't ever be as simple as just applying on procedure to all engines, because a million different things can go wrong, and there are a billion different unique people each with slightly different ways to break down. We're starting to go down a road of designer medicine and it seems very possible to me that some day we'll live in a world that a billionaire willing to spend millions a year can solve their aging. Employ a team of researchers to figure out what's breaking and put it right, but that the average person never will be
Isn't memory also improved by novelty? For instance, your memories before and after a major life event (say, a surgery) are likely going to be more vivid than your memories around an average day (say, day 4000 sitting in a cage). This makes evolutionary sense--novel events should take up more of your limited memory resources than events you've encountered thousands of times before. It also makes me wonder about the methodology behind this paper.
On the other hand, just being able to rest whenever you need and get enough sleep and have time for exersize and great food (which rich people have) is already a huge competitive advantage. So a similar effect as this would produce is definitely already happening.
There's a number of comments here poking fun at the "conspiracy theory" aspect of this. Do people really believe it is a "crazy idea" that ultra rich amoral people would fund research into controversial life and health extension, even at the expense at younger people?
157 comments
[ 2.9 ms ] story [ 152 ms ] threadI was imagining Elon and Jeff keeping a stable with the equivalent of vampire "blood bags".
From the juices of the dying"
Shriekback, Nemesis, 1985.
I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mechanism to moving factors that will cause up regulation, etc, is very novel.
honestly one of my favourite papers in the last five years, I am obsessed.
A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pills and injections are perpetually 5 years out.
I'm aware of at least one that was able to halt or reverse alzheimers in a 200 patient trial, but folded after they couldnt get funding to move forward.
There was also benefit across most measures, but just not of statistical significance.
The trial had some major problems with appropriate controls, and is widely cited as a poster child for why the FDA should not require a control group to undergo invasive brain-surgery, and how this can taint the results.
It also showed a 89% reduction in amyloid Beta, the same proxy measure Biogen's aducanumab was recently approved based on.
https://n.neurology.org/content/neurology/71/3/202.full.pdf
[0] https://doi.org/10.1080/14737175.2021.1960823
[1] https://doi.org/10.1002/alz.12137
There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.
I obviously have biases and an axe to grind, but these are my opinions.
however, the ideas of 1) replacing csf from young to older mice and 2) the idea that there are factors in CSF that are being delivered to other areas of the brain and promoting cell proliferation: that's pretty novel.
all of the literature right now points to csf in terms of waste clearance and csf is painted as almost a river that picks up components and moves waste (e.g. amyloid beta) from the periarterial areas in the parenchyma and then out through the perivenous areas into the lymphatic system. and this means that the idea of delivery of promoting factors is really interesting.
In all seriousness, I wonder if this can be synthesized. A transport layer for brain conductivity, just replace the fluid. Maybe create an even better fluid than what the young hosts have.
Jiffy Brain franchises on the way.
"The solution to pollution is dilution"
I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session?
Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.
It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
https://news.ycombinator.com/item?id=25427090
The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators.
BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/
Google Skq1 on pubmed to see how great it is
A personal experience that comes to mind is when my childhood cat developed kidney disease.
She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
J/K
---
I had a cat when I was in my 20s that got into a fight some eve...
Its face got infected and blew up. It was $8,000 for surgery, and I couldnt afford it - so had to put her down... but I did love that cat, and I would have paid it if I had it...
Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
>Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
Those particular symptoms are common (in cats at least) to feline hyperthyroidism, which is significantly more common than feline diabetes.
Not saying it wasn't Diabetes, but Hyperthyroidism seems more likely.
But gently cutting your arm open and draining a pint into the sink will do the trick!
I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might not be a surprise to see it demonstrated that the cause is in fact the accumulation of errors in the genome that's half-duplicated during spermatogenesis.
Individuals do get less good at it over time, though. The structures described earlier as "shortening" are called telomeres [1], and they do actually do that, as a result of DNA copying being a physically somewhat destructive process. They're purely structural rather than informatic, though, and everyone starts out with a fresh set.
[1] https://en.m.wikipedia.org/wiki/Telomere
I had an internship at the New York State Psychiatric Institute (before I moved into software development). Paternal age was used as one factor in determining if people were at risk for psychotic breaks (schizophrenic prodromes) by one of the assessment tools they developed.
[1] https://www.lifespan.io/news/recombinant-serum-albumin-incre...
you can classify memory into many different components, and how memory in mice translates into humans is not extremely clear.
we can do experiments that do fear conditioning, or classic conditioning and operant conditioning, but the translation from mice to humans is definitely not clear cut. I think this is one of the biggest weaknesses of the paper actually
I would like an account of various bodily components, grown from my personal stem-cells, for injection / growth / use as I see fit.
My Stem Cells My Choice.
---
(for example, I want to regrow my eyeballs.)
Note that your eyeball metabolism can be significantly rejuvenated, e.g retinalamin often reverse blindness in humans. Or Skq1/visomiten. Glaucoma and macular degeneration are totally solved problems. As for myself I want to shrink my eyeballs (myopia) but this is not pharmacologically doable (because extremely undefunded) although Berberine do very significantly slow the myopia progress.
This is why the SV billionaires need to create the metaverse. The matrix had a the right idea, just keep the young plugged in to VR and use machines to do the dirty work.
This old-eating-the-young thing has been going on for time immemorial. It's encoded into our mythology, of Saturn eating his children so that they wouldn't usurp him. And it's not just our (i.e. Western) culture either.
No, It’s because Peter Thiel was (perhaps still is) reportedly interested in it, and that was a big enough story to be eventually lampooned by the comedy show Silicon Valley.
As conspiracy theory, it predates Trump/Qanon, we’ve had David Icke with his adrenochrome from children sucking reptilian royalties
Surely this will give more fuel to the conspiratorial fire.
The day old-gizzards figure out how to sip on young-people juice and live forever, we are truly screwed.
An old tyrannical movie villain dies and a to-be old tyrannical movie villain is born. Billions of people shouldn't be sentenced to death just because the world might be a bit better off if a few people weren't immortal.
You can be almost sure that once the underlying mechanism is known, the necessary stuff will be synthetised instead of being transferred from a young person to an older one. If only to guarantee stable supply, consistent quality and rule out accidental transmission of various pathogens from the donor.
Tyrants aren't even forever even if they never die of old age. After all, tyrants can meet their end through constantly replacing their followers with yes-men to the point of becoming increasingly detached from reality. This may prevent them from noticing certain features of reality such as military incompetence of their force.
The suicide of Hitler certainly was a horrible tragedy to his close family and those who believed into him — for many others it was a reason to celebrate. Similarily death of a young family member can be traumatic to the max, while the death of grandmother which everybody (including herself) already accepted and comes after a live well lived can be even have a certain beauty to it.
Death is not that simple.
Most of the longevity research is trying to stretch healthspan. Stretching lifespan as such is a nice side effect.
We aren't likely to live forever anyway.
I don't like the idea of dying, but the slow slide into immobile sinility is positively terrifying.
I'm in my 40s. I've resolved to look after my health not to live longer, but to extend my health for as long as possible. I'm determined to stay active, mobile and socially/intelectually engaged for as long as I can, partly for my self, but also for my kids.
My kid: Sure, pops, why?
Me：Well, I have a little favor to ask…
https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to...