No one knows for sure how they will be in their old age. My grandmother didn’t seem to struggle until her mid to late 90s. That’s a lot of years to leave on the table. Years that allowed her to meet and enjoy time with her children, grandchildren, and great-grandchildren.
Had she died at 65, I wouldn’t have even known her. Instead she was around for my entire childhood and well into adulthood.
I'd rather live through my 80s without much struggling. Longevity and quality of life until the end. And I try to live in the way that lends itself towards that.
If it's of any help to you: if TFA is true, I should be dead already. I've got the absolute most fucked up sleep schedule. Thankfully I've got a lovely wife who accepted it (to be honest as it's been like that since I was 20 y/o, she knew...).
To me burning the midnight oil is my way of life.
In a past life, two decades plus ago, I used to write books: I'd write at night, when all is quiet. I'd go buy two or three warm "croissant" at 6:30am when the shop would open, then I'd go to bed.
And I love the hours later at night that then becomes early in the morning to get work done.
Because I'm such a night owl (not to party nor drink at all), I've got a different view on, for example, city life. Or rural area life. Things are different in the middle of the night.
Last night I had something that needed solving: went to bed at 8am.
My wife shall never ever take an appointment for me in the morning.
If it's of any comfort to you, I'm still fit and made it to 53 y/o so far and my doctor laughs at me when I go see him, saying I'm totally fine.
Anyhow seeing the old wreck my fater is at 78 y/o, I kinda came to peace with the notion that it's okay'ish if I don't make it that far.
Those with fucked up sleep schedules: you're not alone.
P.S: if I wasn't such a night owl, I'd never have met my wife... Long story but the butterfly effect: 25 years ago, coming back from my editor (who was also a night own) at something like 3am I decided to stop at a club knew but to which I'd never been, for there was some forms of life still awake too. There I met a girl, which became my girlfriend for a while. I kept in touch with her and through her I met a friend: a crazy dude. And through that crazy dude I met my wife. So had I not decided to stop at 3am at that club, I'd never have met my wife. So there's that.
Well that sucks, given I have a gene variant related to delayed sleep according to 23andme.
Last year I did an experiment of sorts while unemployed for a time and found that if I just slept and woke when tired that my sleep time would naturally recess and eventually "flip" after about a month.
My entire life I've wondered why I feel incredibly tired and found waking up so difficult. Turns out that if you follow your bodies dominant sleep cycle it's a synch to wake up. Unfortunately, it doesn't work with modern life very well.
I've found my sleep regularity to be pretty malleable. It can become a habit. When I was in grad school I went to bed at midnight and woke up at 7am. Once I started running more in the mornings, I gradually shifted to going to sleep at 9pm and waking up at 5am.
The first couple days or week will feel pretty bad, but if you give yourself enough time then you'll shift your sleep schedule around. Now I get tired at 8:30pm and fall asleep at 9ish like clockwork. grad school me would have considered that insane considering I'm doing less work on average during the day. My day is just shifted now so that I do more stuff in the mornings and really relax in the afternoons, which is the opposite of before.
A key is actually giving yourself enough time to fall asleep. Most people think they can hop into bed and just get 8hrs, when you actually need to hop into bed around 30mins beforehand and really relax with a book or something.
I also think it's important to not stress about sleep a lot. Unless you're literally feeling miserable or have apnea, I think it's better to just let yourself relax if you wake up in the middle of the night. Sometimes I'll snap awake at 2am and just read for 2hrs, then get 2 more hours of sleep and generally feel fine.
People are different. What you find easy and trainable, someone else will find it doesn't require training and someone else will try as hard as they can and won't succeed.
I also have sleep drift problem and consistenyly had it for the past 7 years.
I discovered that it helps when I actually put in effort to fix my sleep schedule. Like getting off screen 1 hour before I sleep. Boxing bedtime to 23:00-08:00. And similar things.
It is just really difficult to fix for me but it doesn't feel impossible. I have made progress in last 6 months but trying different methods and only some portion of that progress stays permanent.
Also have the same experience fighting depression-like symptoms and anxiety. It just takes a lot of time and is difficult. Some people just don't have these problems and I do but this doesn't mean I am genetically attuned to be like this and I can't do anything. It is just difficult.
I have had a similar experience. I would find my sleep schedule constantly drifting later and later, which made it harder to wake up in the morning, so I would self medicate with caffeine which made me anxious, which contributed to the same cycle. But even when I stopped taking caffeine I always found it difficult to actually go to bed at the same time every day.
What finally worked for me were red light glasses. I wear the True Dark Twilights Classics (though I’m sure there are other brands on the market) for 2-3 hours before bed time and I’m actually sleepy. Way more effective than taking melatonin tablets ever was in my experience. And I haven’t even had to substantially change my screen usage either (though the glasses do make everything come out monochrome, which makes it difficult to use anything that’s not in color blind mode).
Yeah, I'm not sure about the efficacy of those, my understanding is that blocking blue and green light is more important than exposure to red light, but not an expert.
I do still use my phone, and more importantly for me my computer, basically right up until bedtime. I have probably decreased my usage some but it’s not a huge factor.
Good points, if I am careful about caffeine and do all of that it's not unmanageable. Being outdoors and camping and getting good physical activity is the best I found. But it's a struggle for me.
> Also have the same experience fighting depression-like symptoms and anxiety. It just takes a lot of time and is difficult. Some people just don't have these problems and I do but this doesn't mean I am genetically attuned to be like this and I can't do anything. It is just difficult.
Should I mention that "neurodivergence" and different sleep pattern genes have a large co-morbidity? E.g. many people with anxiety / ADHD / dyslexia / depression / etc have a very high likelihood of having delayed sleep or other genes.
You might find some benefit from an app like Wavekength[1] that uses iPhone camera to coach your light exposure, based on current+desired circadian rhythms.
I had that my entire life, and then one day started having the strangest medical condition where it is literally impossible to sleep past ~6:30am.
It sounds unbelievable but you’d have to experience it to understand. But the end result is it “fixed” the delayed sleep issue.
I’d give just about anything to be able to just sleep and keep sleeping, but on the up side now I’m an early bird with extreme regularity and quite like it.
Recalling from college neuroscience classes and subsequent reading of research, the studies show the ordinary human sleep cycle when unrestrained adds about a half hour per day, so 24.5 hours is 'natural'. Long-term studies with all time cues carefully removed ended up with subjects on a ~50 hour sleep schedule, as in awake 36-38 hours and sleeping 12-14hrs.
This is also why it is easier to travel across time zones to the west than to the east.
>Couldn’t this effect be classic cause vs correlation?
Sometimes changing the correlated item, also affects the cause, through a connecting causual change.
E.g.: "Night visits to the fridge linked to high cholesterol".
Now, that's just correlation: it's not the visiting of the fridge, it's the snacking.
But if you read that and stop visiting the fridge, you likely reduce your snacking too as a side effect, and thus lower your cholesterol, without consciously trying to address the primary cause.
I feel like your example is flawed, I just can't put my finger on it.
Maybe it's because I don't see how sleep regularity is a factor you can change as willingly as visits to the fridge, or maybe its because I don't see why people wouldn't just eat more before heading to bed.
It could also just be that I find a treatment of symptoms to be less desirable than causes.
>I don't see how sleep regularity is a factor you can change as willingly as visits to the fridge
In some cases it might be hard (e.g. insomnia), in others it might be as easy as e.g. changing your schedule, or stopping binge-watching/gaming/doomscrolling late, or some such change.
>It could also just be that I find a treatment of symptoms to be less desirable than causes.
It is more opaque.
But the point is not that it's necessarily easy. It's rather than even if X -> Y is mere correlation, by forcing yourself to fix X (even if hard), the resulting changes might also help with Y.
And technically "bad sleep" here isn't necessarily a symptom either. It can be a co-effect of the same symptom.
The article never says anything about causation. It says sleep regularity is a predictor of mortality. That means if you find someone who already has poor sleep regularity they're more likely to die sooner, not that if you force someone into a bad sleep schedule they will become more likely to die sooner.
As always with a lot of these: it's not saying causation.
You might measure the speed of your car by putting your hand out of the window and notice that the wind force on your hand is strong when the car goes fast.
Putting your hand out of the window and then blocking the wind with a book doesn't make the car slow down.
only if the book is being held by someone in the car.
Presumably, the example missed the part where they stated the book was being held in front by an outside agent, because that is the only way it would make sense.
The study is clearly about correlation and not causation, but still the term "important predictor" keeps triggering me. People can't sleep due to stress or noise or disease (e.g. coughing), and while "predictor" seems to be normal science lingo I feel it nudges the conclusion of this study into the direction of causation instead of very clearly saying that it is pure correlation.
Nobody goes to bed and wants to wake up 2 hours later.
But they choose to. Alcohol, caffeine in the afternoon, just not realizing blackout curtains matter, lights or displays on in the room... you can't help someone who isn't making bad choices, but most people can make simple choices that improve their sleep a lot!
We could pick a company car in my previous company (it's a tax thing). We could pick any color, apart from red, because the insurance forbade it - red cars get into more accidents. Somehow that must have made it all the way to the policy without someone asking "is it the red car or the kind of person that picks a red car that causes more accidents?"
I drive a "Victory Red" 2005 Chevy Silverado. I always thought it was a "safer" color for a vehicle.
I have always assumed that, being in a larger vehicle that is bright red, people would be more likely to spot the vehicle from further away, notice it out of the corner of their eye, or that I would generally be MORE visible to other drivers.
I'm sure the correlation insurance companies are looking at is that the driver's of red vehicles are the cause of the higher accident rate.
IDK. I got a hand-me-down sporty car when I was in high school, which was initially white, then I had it painted orange as a birthday gift a year or two later. Comparing the before and after, there was a noticeable shift in how other drivers responded to me, and not universally for the better. I was less likely to go unnoticed (think people trying to merge into me, or jumping out in front of me when they have a yield), but a subset of people (mostly other young men, sometimes older men driving minivans) would act significantly more aggressively. No one ever tried to race me when my car was white. It'd happen like once a week once the car was orange. People actively speeding up to avoid me passing them also increased substantially.
Because for it to be effective it must have reasonable cost compared to the benefit. The cost for such a sweeping lifestyle adjustment seems quite high, and the authors have not showed any benefit to interventions.
There are things that are causal and have little to no effect and things that are causal and have a large effect. I think determining whether and how much something matters, especially when the target audience is "all humans" is a worthwhile endeavor. So it may seem obvious to you, but many many important scientific findings were because somebody looked a little deeper at something that seemed obvious to everyone else.
I wonder how much of this is driven by confounding variables they haven't accounted for.
They do factor in shift work as a categorical variable, and employment status as a categorical variable not taking into account occupation. But probably occupation (not a variable here) interacts with sleep status. Any job that involves a lot of flying (pilot, crew, people travelling for business) get more cosmic radiation exposure, for example, and potentially more sleep disruption. Certain operations and manufacturing jobs correlated with exposure to carcinogens also likely correlate with less regular sleep, possibly in a way that isn't corrected for by the limited shift work categories.
I thought the same. If your life is so in order that you routinely sleep on the same interval, perhaps your life is not as stressful as others who sleep more chaotically
usually these studies are done across a very narrow sample of Earth's population. often from similar region or country etc. Which dont get me wrong, is a lot of stuff to process for such a study, but the number is statistically insignificant. many more similar studies would need to show identical results.
this one selected about 100k people from a dataset of around 500k. All from one country/region (UK)
furthermore they dont measure sleep but they estimate if someone was maybe asleep based data from an accelerometer. so they cannot measure what sleep state someone acheived or if they were actually really sleep or just u know staring at the ceiling in an existential crisis....
> the number is statistically insignificant ... they dont measure sleep but they estimate if someone was maybe asleep based data from an accelerometer
These two goals are kind of at odds with one another. We can only get insight into depth of sleep achieved if we bring you into a sleep clinic, but we can't do that for a significant sample size...
No they didn't. A control group inherently implies the researchers made an intervention in the first place (or else there was a "natural experiment" where people were randomly placed in group or another). That didn't happen here, as this was purely an observational study.
The confounding variable I think is most important is that many people have an internal clock that is shifted or lengthened relative to other people in the same house.
If others in the house prefer to sleep from 10-6 and you prefer to sleep from 12-6, but others start making noise a 6, your sleep quality in the last two hours is destroyed. Then over time, it just results in poor sleep regularity, as you cycle between exhaustion and trying to sleep according to your internal clock.
If you did read the paper, you'd have noticed that people who slept more regularly in this research were also wealthier, and more physically active. They did say they adjusted for these variables, but who knows. Maybe they didn't adjust them enough, maybe there are more covariates they didn't consider.
I don't know if they can have controls for "specific activity that changes their sleep schedule".
In the past few years I went from having relaxed 11AM daily meetings to rigid 8AM meetings, and my sleep has suffered immensely. But nothing else in my life has changed, so it wouldn't show up in my socioeconomic data.
Yeah, this type of observational data often falls over when you dig into the details. And yes, they say they adjusted for a number of variables, but even if hypothetically they perfectly adjusted for all possible confounding variables (highly unlikely IMO), it's possible that the causation simply runs in the other direction: poorer quality sleep and variable sleep cycles could just be a symptom of illness or being generally unhealthy, not the root underlying cause.
As my diabetes has progressed, I find myself sleeping more odd hours (it can be hard to fight off the tiredness that comes after a meal), and I can be frequently woken up my extreme lows where my body is screaming for carbs.
I kinda realize that the most important factor for personal success (whatever kind of success you want) is mental stability.
Like, John Carmack said that he NEVER burned out, never went into a dark corner (verbatim from his interview), and everyone agrees that he works like a machine. And I don't think he actually spent a lot of mental training to achieve that stability, because, he has been like that from a young age. This is THE best thing you can have in the world, if you want to achieve something, anything. If you don't have the mental toughness, you won't be able to make through that 10,000 hours (cliche, I know). I guess that's also why many self-help book talk about being consistent -- to be consistent, is to have mental stability. And I think there is a whole difference, between someone who trains his mental to stay stable for 6 months, then collapse, from someone who actually doesn't need to train and just be stable somehow.
This also leads me to realize that good sleep is one of the fundamentals of a stable mind. As a parent, I actually don't remember when was the last time I had a good sleep, and my definition of a night of good sleep is perhaps just trivial for someone else. At the same time, I consider myself lucky, because at least I don't suffer from serious mental issues. I still have a job and a house, and that's better than many out there.
This then leads me to despise the human body. It is a machine so delicate that you have to be very lucky to be super productive, whatever your definition of being productive is. It seems to ignore the input in short term (e.g. you can eat garbage food for a month and nothing really happens, or, you can sleep 4-6 hours every day for the last 6 years and still function normally), but once the long term shows up it is very hard to reverse. And there are so many theories focused on it that we have no idea which one is best for the individual. You might as well spend years doing A/B test on yourself and still have no idea what the hell is going on. Or you need to be super rich to have some medical team monitor you 7/24 to figure out what the hell is going on.
Carmack always seemed to have a really strong idea on what was important for him to work on. How much of that is mental toughness vs having a believable purpose?
Believable is important because you have to internally 100% without a doubt believe that what you're doing is the right thing to be doing now.
As soon as the "what ifs" starts to creep in for the big picture items or goals, that can destroy everything. I'm not talking about running into a technical implementation problems along the way (those can be fun), it's more like "did I pick the right language for this?" level of questions that sit in the back of your mind.
Personally when I find something to work on that I like and will have what I think is a favorable outcome, it's easy to put in 8-10 real 100% laser focused hours into a task every day, even if it spans weeks or months. I'd like to think most people can do this too, the hard part (for me at least) is having these things to work on.
You are spot on. I see all this in me, too. Very interesting to encounter your take.
I try to turn what-ifs into actions. Instead of a what if rumination it is a small task, or a small trial of something, or a move in general forward rather than not. Not even remotely close to doing this well all the time, but I notice an overall boost in mood and productivity when I reorient my mint to progress rather searching in the uncertainty space.
I sometimes think about the same. Its a sad truth that if you bad days those days may be at the worst moment. Sleep definitly helps for a good mind but also exercise!
This makes sense to me as a correlation. Mental health disorders alone seem like they’d contribute significantly.
ADHD, for example, is correlated with both sleep cycle issues and worse outcomes in life (including higher rates of crime and participation in risky activities).
Having just spent a few months reading circadian entrainment papers for a circadian rhythm app I just finished,[1] I wonder if this effect might be about circadian amplitude[2] (rather than phase, which has gotten more attention).
I have seen many doctors, including sleep specialists, regarding insomnia. They all pointed to one source as the reason for the sleep issues: stress. And they all wanted to put me on prescription sleeping pills. I said no to that. Sleeping pills can cause dependence, and they often treat the symptom rather than the underlying cause. As a software developer, I am used to finding and fixing the underlying problem instead of relying on the quick fixes these doctors were offering me.
After much research, I figured out what I believe was the underlying problem, and the fix for it. The underlying problem was magnesium deficiency. As a software developer, I spend much of the day doing mentally demanding work. This is the kind of stress the doctors were talking about. Stress can increase the body's demand for magnesium and may contribute to low magnesium levels.
The cells in our body depend on minerals such as calcium and magnesium for normal function. Calcium plays an important role in activating muscles and nerve cells, while magnesium helps regulate calcium activity and supports relaxation of muscles and the nervous system. When you are low on magnesium, your muscles may remain tense and your nervous system may have a harder time settling down. That can contribute to muscle stiffness and difficulty sleeping.
The solution, in my case, was magnesium supplements. They fixed my muscle stiffness issues and my sleep issues. A special form of magnesium called magnesium L-threonate may be especially helpful for the brain because it appears to raise brain magnesium levels more effectively than some other forms.
Magnesium is a great supplement in general. You can definitely have too much in your system and that is undesirable, but a bit before bed time along with 1-3mcg of melatonin work well for me. It is nice after workouts. I use magnesium glycinate in powder form, which is more bioavailable than some forms as well.
I also find sauna before bed is good. I have a bed chiller so I can crank up the sauna before bed and not sweat a lot. Generally if I sauna and take the aforementioned supplements I sleep well. Exercise also seems to help me out a lot. If I exercise during the day, and a 4-5 times that week in general, I tend to sleep well.
Mg or melatonin have 0 effects on me, Mg helps if I over-exercise but thats for muscles regeneration.
I dont have problems normally, just cant sleep in high altitude, 3000m is already showing mild effects. Guess what, I do/did quite a bit of mountaineering, its easy to get above 5000m in himalayas, highest I've been in tent attempting to sleep before summit push was 6000m on Aconcagua. Tried both Mg and melatonin up there over multiple nights, 0 improvements. I had highest O2 blood level measured in 5500m by doctor (mandatory there) from whole group.
Physical effort makes better sleep for literally everybody, thats age old knowledge and I havent met a single exception yet.
I wonder if that is an adaptation time problem? It takes about a month for the body to fully adjust. I live at 1500m elevation in the Denver area of Colorado, but I do recall feeling more restless during sleep at elevation before I lived here.
> One might object that they do not wish to tamper with their natural sleep, even if melatonin is a normally-secreted hormone.
> Sad to say, I would point out to such readers that they are already profoundly tampering with their natural sleep cycle, and indeed, all of Western civilization is tampering with it; most of my readers do not even sleep multiple times during the day, as ‘Nature intends’ and as humans have usually slept through history, but rather in a single 7–9 hour long block.
> [...]
> Finally, there are multiple lines of research suggesting chronic sleep deprivation is prevalent among young adults (including historical comparisons). It is striking that unemployed adults sleep a full hour longer than the employed , and that when normal adults are placed in settings without artificial light like camping or without any time indicators, they sleep longer than before - exactly as if they were sleep deprived.
I take melatonin to sleep on a redeye, but otherwise don't use it. I find the effect is similar to taking a weed edible to fall asleep— basically, my wearable registers a lengthy period of deep sleep but instead of waking up feeling refreshed and ready for action, I'm groggy and fog-headed for several hours, or dependent on coffee to reverse the lingering effects.
As someone who has never been a regular coffee consumer, I really didn't want to end up with the dual dependence of melatonin at night and then caffeine in the morning.
This thread is stimulating me to want to get my magnesium checked, but barring that I've found the most effective sleep interventions are the basic ones: get some exercise earlier in the day, and don't do screens for the last few hours before bed.
"and don't do screens for the last few hours before bed" because that will help you fall asleep more quickly? or because that will help you sleep later in the morning 6 or 7 hours later? People never seem to mention that key aspect.
For me most things I do on a screen are fairly mentally stimulating (like video games), and even the ones that aren't (like watching a movie) inhibit the feeling of sleepiness I get when I abstain. So, it's better for falling asleep quickly.
The comment above just said “sleeping pills” which is ambiguous. Melatonin is an OTC supplement. True “sleeping pills” are usually controlled substances and few doctors would prescribe them as first-line options for a patient who shows up with first time complaints of sleep problems. They won’t be prescribed long-term either. The part of the post that says doctors (plural) tried to prescribe the pills makes me think it’s not traditional sleeping pills, because in this environment you would be unlikely to find one doctor willing to prescribe scheduled sleeping pills long term at all, let alone multiple doctors pushing them.
The usual suggestions from doctors for first line treatment are more mild medications that have drowsiness as a side effect, prescribed at low dose. I would actually prefer many of these low dose options over some of the high dose melatonin supplements. Melatonin is a hormone and taking it can throw off natural production
Lots of people take diphenhydramine products as sleeping pills and they are advertised as such OTC in the US. Long term Diphenhydramine use is associated with many negative health outcomes and despite the warning labels many people become dependent on them.
Yes - I saw a very interesting video the other day that educated me a lot on Benadryl - apparently it has a lot of side effects, can cause dementia, and is probably best avoided.
The parent post was talking about doctor prescribed medications.
The reason diphenhydramine Is associated with a slight increase in dementia risk is the anticholinergic properties. This risk increase is from correlational studies on other medications with anticholinergic medicines being taken for many years by elderly people, so the risk of taking Benadryl occasionally is low to none.
The prescription alternatives like doxepin have the same antihistamine properties without the anticholinergic properties when used at the prescribed dose.
This is an example where people can get themselves into the wrong outcome by assuming anything their doctor prescribes is a last resort quick fix, but anything they can source by themself is safer and superior.
Tramadol is routinely prescribed long term where I live. I know someone with a massive bottle good for something like 6 to 12 months of daily use. (I don't know if that's a good thing but it is certainly a thing.)
This is a very important paragraph from quern's article
> There are few to no side-effects to melatonin use in adults (there is uncertainty about the risks & benefits in children & adolescents28), and it is not addictive or habit-forming like caffeine is. The usual dose for a night is 0.5-3 mg and I take 1.5mg [29]; my dose is highly likely to be too high. High doses may well be responsible for why some people try melatonin and report that it does nothing or hurts them, since in one study, the best dose for old people was 10x smaller (0.1mg or 0.3mg) and for one blind person, 0.5mg [30 31 32] . Zhdanova et al 1996 found 0.3mg & 1.0mg to affect sleep onset similarly. A study of delayed-release melatonin found with their high dose of 4mg (but not 0.4mg) elevated melatonin levels 10 hours after bedtime ( Gooneratne et al 2011) - potentially interfering with waking time.
It is difficult to find doses as small as 1mg sublingual (dissolve under the tongue) in my area. Everyone is trying to sell you 5-30mg chewables. And, I expect everyone is buying them under the assumption that more is better. But, here it explicitly is not.
The way melatonin works well for me is to wait until I'm already settled into bed and should be asleep, but I'm not. Do a couple body scans to relax for real. Try to think about something mindless. Then if I'm still awake, pop 1mg under my tongue. I'll usually wake in the morning with half of it drooled on my pillow :P
Natrol makes a 1mg gummy and Vitafusion has a peach flavored 1.5mg gummy (sold as “3mg” but the dose is “two gummies.” My kids use these. I get them on Amazon.
From your description it may be acting as a placebo -- the act of putting the pill into your mouth is what tells your subconscious to activate a sleep cycle.
I've had the same problem finding low-dose melatonin in brick-and-mortar stores, but Natrol sells a 1mg dissolving tablet on Amazon. If I need a sleep aid, I break it in half for a ~0.5mg dose, chew it with my front teeth, then hold it under my tongue for a bit before swallowing what's left.
It usually takes 15-30 minutes before I get noticeably drowsy, but I feel no more groggy the next day than if I slept sober.
For low dose melatonin, try liquid melatonin. Around here Sprouts carries it, but you gotta look a bit to find it. The bottle says 30 drop equal 3mg. So you can take small doses easily, and it absorbs under your tongue pretty quickly.
It's a bit harder to find, but I've had a good experience with liquid melatonin. Each drop contains like 0.1mg, so it's easy to dial in the small dose that you need.
I agree with Gwern in that I think for the vast majority of people, short-term melatonin supplementation is useful and can cause little harm, and it is extremely safe as far as supplements go.
But I don't think it does anyone any favors to oversell the idea that it has "few" or "no" side effects -- it has mild side effects, most commonly reported in the literature are daytime fatigue, headaches and GI symptoms, and also nightmares. Mild doesn't mean it isn't a nonstarter for some people.
It's also important to remember that there are major gaps in what we know about melatonin; notably the effects of chronic supplementation are not well-studied, but earlier final awakening has been documented and this is quite commonly reported in anecdata -- I can contribute a datapoint there, as can most people in my circles who have used it.
To be clear, melatonin is great and useful, but as someone with a rare lifelong chronic sleep disorder who is intimately familiar with this substance, I think it's most useful when we're clear on what we know, what we don't know, and what actually are the limitations on a substance.
Just because downing a bottle of it probably won't cause systemic organ failure or otherwise any kind of medical emergency in most people doesn't mean there aren't tradeoffs to consider when using it, especially if you are sleep-challenged
The evidence that humans would naturally be designed to sleep “multiple times a day” is quite mixed. “Multiple” does a lot of heavy lifting here, when basically most evidence points to two batches, following either of these patterns:
- a long uninterrupted night cycle and a short (20-60 mins) afternoon nap. Around 2pm.
- a night cycle split into two halves. With a 1-2h break (maybe up to 3h) starting around midnight to 2am.
The former is still very common, and imho stretching the definition of multiple cycles. The latter is more historical (more common when there are long winter nights and no electricity).
Also making it a “Western” problem is kinda weird? There are other cultures where single cycle sleep has existed. Even hunter-gatherer groups with little to no contact with the west. And alternatively afternoon naps are still quite common is some western areas. I guess the main thing that prevent it would be the classic work day schedule.
Everyone is different so I'm not suggesting this as a general cure-all, however I'd like to relate my own personal anecdotal experience.
I've always had insomnia since I was a kid and I just chalked it up to "being a night owl." As a teenager, I mostly solved this by living in a permanent fog during the week and "catching up" by sleeping in on the weekend. As an adult, I was suffering greatly from chronic sleep deprivation because adults (mostly) don't have much control over when they can wake up to start the day.
Around 10 years ago, I started taking 5mg melatonin. It's going to sound like I'm overselling it, but it changed my life. It _very reliably_ makes me sleepy 1-2 hours after I take it. If I forget to take it, I am fully awake until the wee hours of the morning. Is it important to note that (for me), after I take it, I have to engage in some passive activity like (calm, non-shouty) YouTube repair videos or reading. Also, the "window of sleepiness" is at most about 30 minutes and if I decide to power through it, I will come out the other side fully awake again. Melatonin does not "force" me to sleep, only highly encourages it.
I was skeptical of melatonin for the longest time. Generally, I rarely see much if any positive effect from supplements. But (for me!) this stuff really works. If anyone reading this is on the fence, I highly recommend giving it a try. (With the acknowledgement that it takes about a week to get into a solid sleep schedule if yours is currently disorganized.)
For me glycine helps amazingly. It's an amino acid that the brain needs during sleep. I take about 5 grams in water about an hour before I go to sleep. I'm not sure how much the glycinate in magnesium glycinate has the same effect.
Oddly, it has the opposite effect as sleeping pills on me, it doesn't make me sleep more but I'm more rested when I wake up. It even happened a few times that I only slept 5 hours but still could focus well at work and bike intensively for an hour in the evening, without glycine that was impossible.
At 20 euro/kg I think I'll take it for the rest of my life, and it probably will add a few years to my life.
So where's the advert link to his favourite supplement, search those phrases and there will be 200 different brands selling this same commodity
so which one is paying him commission ?
All?
Hmmmmmmm
People sharing their experience doesnt immediately mean AI-generated advert
I'm not taking either side but people don't need to directly link to their own store to benefit from increased awareness and "hype" in some product category - a rising tide lifts all boats.
"Health" and more specifically the supplement industry is just a revolving door of fads. There's also survivorship bias, those who are obvious get banned quickly.
All of those supplements are made with “magtein (r)” branded magnesium l-threonate. It all goes back to the same company and that company is the one that has supplied the “studies” that prove its effectiveness. And by “supplied” I mean that the literal vice president of the company’s research arm was an author on at least one of their studies but didn’t disclose his connections until a follow-up update to the study.
I don’t think it’s AI-generated, but it is repeating a lot of the points that are commonly repeated in supplement ads: The claim that Mg L-threonate is special originates from the person who patented it and sues anyone else who produces it. The claims that multiple doctors tried to push “sleeping pills” and they’re all bad is a common theme in communities that accept supplement research and claims unquestionably (like patented magnesium forms being superior) but have an innate distrust of doctors and medicine.
I think this is just what happens if you read a lot of supplement forums and listen to the supplement podcasts a lot: You start developing elevated beliefs about the supplements, disdainful beliefs about doctors, and think you’re making superior choices having done your own research. That last point is some times critical for the supplements working, because if you believe you’re taking something special after having cracked the mystery by listening to 50 hours of Huberman or Rhonda Patrick (as examples) then the placebo effect will supercharge the result. Having belief that you’ve solved the problem makes the effects much stronger, especially for cases like this where the underlying problem was already pointed out as being stress related.
Histamine has different pools, functions, and receptors in the body. You’re reducing it all to one single level that goes up or down with diet but that’s not how it works.
The brain histamine in your neurons is primarily synthesized from an amino acid. The histamine levels in neurons are different than the levels in mast cells.
There are a lot of degrees of hand waving in your theory that don’t work.
> Magnesium supplementation solved my sleep issues.
Which type, if you don't mind my asking? And how long did it take before you felt the benefits? I took it for a month once (forget which type) an hour before bed and nothing changed.
Magnesium Glycinate has been a game changer. My legs used to be tense to the point of cramping at night, and they’re now relaxed, enabling better sleep. I also use L-theanine as an additional supplement for a long duration deep sleep, and think it helps.
> As a software developer, I am used to finding and fixing the underlying problem instead of relying on the quick fixes these doctors were offering me.
I get what you’re saying, but I think it’s fair to view it as equivalent to drinking a protein shake after a workout. You used the resources in a productive and healthy way, now you need to replenish them.
sure if you're just taking it as a dietary supplement, but clearly OP is using it as a form of sleeping pill. which is also fine but just seems like mental gymnastics.
I can also vouch for magnesium and the l-threonate variant. I take both before bed along with glycine powder, phosphatidyl-serine, l-theanine, l-tryptophan, ashwagandha, and saffron. No melatonin, no sleeping pills. Finally getting decent sleep for over a year now.
> A special form of magnesium called magnesium L-threonate may be especially helpful for the brain because it appears to raise brain magnesium levels more effectively than some other forms.
The study that made this claim was performed by the person who patented magnesium L-threonate and sells it at a high price. They go after any company that tries to sell cheap generic versions. The study was in mice and only showed small increases.
Magnesium L-threonate doesn’t get absorbed into your body and go into your brain as a lot of the supplement podcasts and social media posts have been implying. Magnesium supplements like this dissociate into their components in your digestive tract. Magnesium and threonate get absorbed separately. So if magnesium L-threonate has some special properties, it would be because threonate does something to improve absorption or maybe has other effects in the body, but that’s a big if. Remember that the person claiming it works better has been making a lot of money off of that one study.
If you have the cash and don’t mind paying the price then there’s no reason to switch. Many people find that magnesium glycinate, which is cheap, works just as well if not better. Glycine supplementation has been found independently to improve sleep, so taking a magnesium supplement that dissociates into magnesium and glycinate might be helpful in its own way.
Magnesium builds up in the body. Some people are deficient and get strong effects from initially correcting the deficiency. Take high doses for too long and you can start accumulating enough to get into excessive magnesium range, which brings problems. That was previously a rare observation but it’s occurring more as people get into magnesium supplements from podcasts that encourage constant high dose protocols and repeat claims that everyone is severely deficient. Keep the dose moderate.
I tried magnesium before but didn’t see any effects after a week so threw in the towel. Then I read a comment by someone here that had the exact same symptoms as me (brain wouldn’t turn off), explained the underlying cause, suggested L-threonate, and explained that it’s a long-term deficiency and might take some time to build up sufficient reserves.
I have had insomnia my entire life, since I was a child. I would go to bed around midnight and fall asleep at 3am, if I was lucky. I simply could not get my brain to disengage.
Within a month of supplementation, I thought I noticed a bit of improvement. By two months, my insomnia was gone. Not better. Gone. I fall asleep within minutes now.
Trained doctors pushed opiates and benzos on me when they were very much not needed and in both cases led to dependancies and horrific withdrawals. I'm sure many others can chime in with their own similar experiences. Medical professionals are incredibly crucial to the wellbeing of society, but they have also been responsible for much suffering because they are human just like us.
Do you know they’re wrong? Please don’t invoke Dunning Kruger like this, it’s cliché and also wrong to do. There’s no indicator for whatever it is Dunning & Kruger showed, you cannot know if it applies to a single person. Their main plot showed a positive correlation between confidence and competence. Their paper has problems, their methodology has been rightly questioned, and some attempts to reproduce have failed. Plus keep in mind that, ironically, for people who are intimately familiar with the debate over DK, using it to essentially name-call someone backfires and has the opposite of the intended effect, it makes the name caller look confidently ignorant.
Those invoking Dunning-Kruger are, with high probability, an instance of just that :) (also, see the comment below that touches upon the many gaps in the original paper, which is at this point just garbage invoked by midwits). Finally, there’s a thing called heterogeneous treatment effects, which really is hard to detect at medical research scale … and placebo effects, if they help with the underlying issue without breaking the bank, and still helpful.
From my experience, it took about a month of 150mg magnesium supplementation per day to see effects, two months for my insomnia to go away entirely.
Doing a quick search for magnesium-rich foods, it seems like it would take either an unsustainable focus on eating these foods to see results on a similar timeline or an extremely prolonged timeline to see similar results.
That said, I am not a doctor or nutritionist. But my instinct is that you can get so far in the hole with a lifetime of magnesium deficiency that supplementation is by far the most time- and lifestyle-efficient to digging yourself out. Whether or not switching to magnesium-rich foods can sustain you being at correct levels will end up depending on what the size of the deficit was in the first place, but is probably worth a try.
Speaking of which, I think it's a great idea for everyone to get their vitamin levels checked. Your doctor is unlikely to order such a blood test unless you are in an extreme situation, but it's cheap (around $100) to get a pretty extensive panel done.
I did it recently and found out basically all my b vitamins were in the toilet along with my vitamin D level. I started taking a b complex vitamin and D3 supplement and found immediate improvements to brain fog and exhaustion.
A lot of doctors only want to do a more critical set like like triglycerides, c-reactive protein, cholesterol, stuff like that. I've never had a doctor proactively want to test things like b vitamin levels.
I find magnesium great - but I also like 5-HTP which I find also helps me sleep if I take it with a little food about 30 mins before bed. I find I feel a lot calmer when taking it - and it helps my ADHD - though I don't take it for too long, as I never like to take anything for too long.
The only thing I did take for a long time was Fenugreek seed extract, but recently read long term us is potentially toxic, so stopped that, but I really liked how that made me feel.
> As a software developer, I am used to finding and fixing the underlying problem instead of relying on the quick fixes these doctors were offering me.
I'm skeptical that avoidance of "relying on the quick fixes" generalizes to software developers as a whole :)
Retired software developer and my wife suggested the same and it worked. As a veteran I also believe it mostly fixed my sleep apnea episodes that I never sought formal diagnosis for before. We also do 5 mg melatonin now which helps. The magnesium oxide at bedtime is great though.
My problem is that I'm always sleepy throughout the day and when I have to go to bed at nigh, then I feel so active and energetic, as if my body tries its best to avoid sleeping.
I was in the same boat as you and it seems I solved it.
What I did :
- LSD (microdosing + a semi dose one year ago) did absolute wonders on my anxiety (which was what kept me energetic). I would then describe myself as having a general anxiety disorder and I now describe myself as chill af. It's amazing. I'm still stressed out by things but that's normal and not my default mode anymore.
- Prolonged-release melatonin keeps me asleep for the whole night
- Took the habit of reading in the bed. I'm so tired that most evenings, I have a really hard time to read 5-10 pages, I must fight to keep my eyes open.
okay, I'm curious, have you build an addiction? or do you think you can keep on reducing the dose and stop using it but still have the benefits. I've read somewhere that LSD can kind of re-wire your brain
LSD has risks, especially if you're already prone to certain kinds of mental illness (you might not know it), but addiction isn't really one of them.
Going for a walk can also rewire your brain, but doing so on LSD will probably rewire it more quickly. Whether that's good or bad depends on whether you do a good job with the rewiring. It comes down to how well you trust yourself.
I do that, it seems like a self-reinforcing pattern I end up in after messing up my sleep schedule. I take a sleep aid (like Zzzquil) for a bit to get back on schedule. Caffine before 1pm or so helps too.
This is a shifted circadian rhythm. If you get up late, you'll be sleepy late; additionally, blue-light exposure at night (from screens) suppresses melatonin production and can delay onset. The fix isn't to "go to bed early" first, it's to get up early and get exposure to sunlight then and during the day, and the sleep pressure in the evening will follow in kind. This is further facilitated by giving yourself time in the evening to wind-down away from screens, by having a ritual/routine (an hour at least) such as preparing breakfast, reading, doing yoga, whatever.
Think of it like jet lag. If you travel to the other side of the world, you rapidly shift schedule in accordance with your habits (the timing of your meals, light exposure, activity, socializing etc), whether that be night or day. These inputs more than ever influence morning-ness or evening-ness qua chronotype, with the advent of limitless evening light and entertainment.
I'm really pissed that I went through 6 cloudflare captcha loops with no result. I swear they're guarding this website from VPN users as if it's the fort knox.
What's missing is how much ability you have to sleep, rather than some sort of sometimes controllable factor like schedule. In my case, my brain wakes me up with anxiety one hour or more before the alarm rings (I never check time, I'm guessing). My room is always cold and relatively dark - not photo development dark, but not far.
The cortisol spikes are what get me. I can drink or not drink, exercise or not exercise, take magnesium or not take magnesium. The brain wants to tell me at 630 or 7 all the things that can go wrong or todos, instead of letting me sleep til 8. Sometimes it's much earlier than that.
I also wake up at the slightest sound or movement. It's been like this since I was a child. I'm defective, and all the bro science Youtube videos with top 10 science -based 'hacks' don't solve the problem. Know what does? Anti anxiety medication, but doctors don't prescribe benzos anymore.
I do bi/tri phase sleep, 6 hours at night, and 1-2 naps a day (I work remotely so allows me to nap when I want) This is the best, sleep when you need to you body knows best.
Do you think our ancestors slept exactly 8 hours a night from 10pm to 6am? No they slept when they wanted.
> Do you think our ancestors slept exactly 8 hours a night from 10pm to 6am?
Yeah I pretty much do expect that (but more like 6 or 7). They were awake a few hours after sunset by fire light, then get up fairly early. I certainly don't imagine them napping during the day, when they could be working together to get food, unless it's a climate where it's too hot to do anything in the middle of the day.
Studies of modern hunter gatherers seem to back this up e.g. [1]
It's widely known that Victorians would have two sleeps over night, with a productive period in the middle, but this seems to be a misconception based on a passing remark in one court case. Even if true, this is a post-industrial society with unhealthily long working hours and I don't think we should be copying their sleep patterns.
Watch male lions they sleep when they want, laze about all day until they need to eat. Or you can be a deer caught in the corporate wage slave, alarm clock prisoner headlights.
I've tried this but naps make me groggy for the rest of the day, or sometimes I get confused thinking it's the next day. What's your secret to waking up refreshed from a nap?
My PhD advisor likes to drink a coffee just prior to falling asleep. That way the caffiene slowly kicks in and wakes him up. I can't do this--I already have trouble sleeping and I feel the effects of coffee quickly.
But to answer your question-- for me, washing my face helps a lot. I don't know why. Not that I nap all that often.
I have epilpsy, with an implanted device that both acts like a pacemaker and records my brainwaves.
Basically my doctor's biggest concern right now is making sure I don't die in my sleep because of something the device records that I and my wife never even know happened. Its a point of debate right now how much to disrupt my life with side-effects to do that.
I read the abstract, pretty interesting. I did a word search for "wake" looking for if they talked at all about early waking times being correlated with overall regularity, as that has been my personal experience. Unfortunately they didn't talk about it, or if they did I couldn't find it.
I am also curious about this. The best sleep I ever had was when I was teaching an early morning class. Part of my morning routine is a short run, so this meant I was regularly waking up at 5am. I fell asleep regularly at 9pm when I was on this schedule. I use a sleep band [1] to track sleep, and it was the only time when I've been able to consistently get "high scores" on it.
The only thing that has worked for me to keep my sleep regular is to go outside first thing in the morning and sit for 15-20 minutes. Rain or shine. Even if it's cold or cloudy.
This has been game changing and keeps me on a regular sleep routine.
Seconding that the time you get up, and light exposure then and during the day, has a massive impact. If you habitually sleep in late, then "going to bed early" does not work as you'll lack sleep pressure. It's putting the cart before the horse. You have to treat it the same way we do jet lag; when we travel to the other side of the world, we adjust by just gritting through the morning. Takes few days to shift.
193 comments
[ 3.3 ms ] story [ 62.2 ms ] threadHad she died at 65, I wouldn’t have even known her. Instead she was around for my entire childhood and well into adulthood.
To me burning the midnight oil is my way of life.
In a past life, two decades plus ago, I used to write books: I'd write at night, when all is quiet. I'd go buy two or three warm "croissant" at 6:30am when the shop would open, then I'd go to bed.
And I love the hours later at night that then becomes early in the morning to get work done.
Because I'm such a night owl (not to party nor drink at all), I've got a different view on, for example, city life. Or rural area life. Things are different in the middle of the night.
Last night I had something that needed solving: went to bed at 8am.
My wife shall never ever take an appointment for me in the morning.
If it's of any comfort to you, I'm still fit and made it to 53 y/o so far and my doctor laughs at me when I go see him, saying I'm totally fine.
Anyhow seeing the old wreck my fater is at 78 y/o, I kinda came to peace with the notion that it's okay'ish if I don't make it that far.
Those with fucked up sleep schedules: you're not alone.
P.S: if I wasn't such a night owl, I'd never have met my wife... Long story but the butterfly effect: 25 years ago, coming back from my editor (who was also a night own) at something like 3am I decided to stop at a club knew but to which I'd never been, for there was some forms of life still awake too. There I met a girl, which became my girlfriend for a while. I kept in touch with her and through her I met a friend: a crazy dude. And through that crazy dude I met my wife. So had I not decided to stop at 3am at that club, I'd never have met my wife. So there's that.
Last year I did an experiment of sorts while unemployed for a time and found that if I just slept and woke when tired that my sleep time would naturally recess and eventually "flip" after about a month.
My entire life I've wondered why I feel incredibly tired and found waking up so difficult. Turns out that if you follow your bodies dominant sleep cycle it's a synch to wake up. Unfortunately, it doesn't work with modern life very well.
The first couple days or week will feel pretty bad, but if you give yourself enough time then you'll shift your sleep schedule around. Now I get tired at 8:30pm and fall asleep at 9ish like clockwork. grad school me would have considered that insane considering I'm doing less work on average during the day. My day is just shifted now so that I do more stuff in the mornings and really relax in the afternoons, which is the opposite of before.
A key is actually giving yourself enough time to fall asleep. Most people think they can hop into bed and just get 8hrs, when you actually need to hop into bed around 30mins beforehand and really relax with a book or something.
I also think it's important to not stress about sleep a lot. Unless you're literally feeling miserable or have apnea, I think it's better to just let yourself relax if you wake up in the middle of the night. Sometimes I'll snap awake at 2am and just read for 2hrs, then get 2 more hours of sleep and generally feel fine.
I discovered that it helps when I actually put in effort to fix my sleep schedule. Like getting off screen 1 hour before I sleep. Boxing bedtime to 23:00-08:00. And similar things.
It is just really difficult to fix for me but it doesn't feel impossible. I have made progress in last 6 months but trying different methods and only some portion of that progress stays permanent.
Also have the same experience fighting depression-like symptoms and anxiety. It just takes a lot of time and is difficult. Some people just don't have these problems and I do but this doesn't mean I am genetically attuned to be like this and I can't do anything. It is just difficult.
What finally worked for me were red light glasses. I wear the True Dark Twilights Classics (though I’m sure there are other brands on the market) for 2-3 hours before bed time and I’m actually sleepy. Way more effective than taking melatonin tablets ever was in my experience. And I haven’t even had to substantially change my screen usage either (though the glasses do make everything come out monochrome, which makes it difficult to use anything that’s not in color blind mode).
Might have to try that myself. Do you still use your phone/tablet/etc or does it also encourage you to use them less?
I do still use my phone, and more importantly for me my computer, basically right up until bedtime. I have probably decreased my usage some but it’s not a huge factor.
> Also have the same experience fighting depression-like symptoms and anxiety. It just takes a lot of time and is difficult. Some people just don't have these problems and I do but this doesn't mean I am genetically attuned to be like this and I can't do anything. It is just difficult.
Should I mention that "neurodivergence" and different sleep pattern genes have a large co-morbidity? E.g. many people with anxiety / ADHD / dyslexia / depression / etc have a very high likelihood of having delayed sleep or other genes.
Disclaimer: I made the app.
[1] https://www.impulsearc.com/wavelength/
It sounds unbelievable but you’d have to experience it to understand. But the end result is it “fixed” the delayed sleep issue.
I’d give just about anything to be able to just sleep and keep sleeping, but on the up side now I’m an early bird with extreme regularity and quite like it.
It's it really? What if you go to bed at 6am? Will you really still wake up 30 mins later?
Recalling from college neuroscience classes and subsequent reading of research, the studies show the ordinary human sleep cycle when unrestrained adds about a half hour per day, so 24.5 hours is 'natural'. Long-term studies with all time cues carefully removed ended up with subjects on a ~50 hour sleep schedule, as in awake 36-38 hours and sleeping 12-14hrs.
This is also why it is easier to travel across time zones to the west than to the east.
Perhaps someone who has a consistent schedule is hypothetically more likely to make healthier choices on average?
Sometimes changing the correlated item, also affects the cause, through a connecting causual change.
E.g.: "Night visits to the fridge linked to high cholesterol".
Now, that's just correlation: it's not the visiting of the fridge, it's the snacking.
But if you read that and stop visiting the fridge, you likely reduce your snacking too as a side effect, and thus lower your cholesterol, without consciously trying to address the primary cause.
Maybe it's because I don't see how sleep regularity is a factor you can change as willingly as visits to the fridge, or maybe its because I don't see why people wouldn't just eat more before heading to bed.
It could also just be that I find a treatment of symptoms to be less desirable than causes.
In some cases it might be hard (e.g. insomnia), in others it might be as easy as e.g. changing your schedule, or stopping binge-watching/gaming/doomscrolling late, or some such change.
>It could also just be that I find a treatment of symptoms to be less desirable than causes.
It is more opaque.
But the point is not that it's necessarily easy. It's rather than even if X -> Y is mere correlation, by forcing yourself to fix X (even if hard), the resulting changes might also help with Y.
And technically "bad sleep" here isn't necessarily a symptom either. It can be a co-effect of the same symptom.
At least they aren’t shift workers
You might measure the speed of your car by putting your hand out of the window and notice that the wind force on your hand is strong when the car goes fast.
Putting your hand out of the window and then blocking the wind with a book doesn't make the car slow down.
Keyword: "associated"
...yes it does?
Presumably, the example missed the part where they stated the book was being held in front by an outside agent, because that is the only way it would make sense.
Nobody goes to bed and wants to wake up 2 hours later.
On the other hand racing stripes have zero impact, but do correlate to the speed of the car.
I have always assumed that, being in a larger vehicle that is bright red, people would be more likely to spot the vehicle from further away, notice it out of the corner of their eye, or that I would generally be MORE visible to other drivers.
I'm sure the correlation insurance companies are looking at is that the driver's of red vehicles are the cause of the higher accident rate.
But what they are saying is, it would be valuable if it was causative wiggles eyebrows
Last sentence of the abstract:
> Sleep regularity may be a simple, effective target for improving general health and survival.
But why would it NOT be? Seems stupid for us to have evolved into beings that need our sleep to be irregular.
Technically the book would add drag and the car would slow down but likely imperceptibly to a mere mortal
They do factor in shift work as a categorical variable, and employment status as a categorical variable not taking into account occupation. But probably occupation (not a variable here) interacts with sleep status. Any job that involves a lot of flying (pilot, crew, people travelling for business) get more cosmic radiation exposure, for example, and potentially more sleep disruption. Certain operations and manufacturing jobs correlated with exposure to carcinogens also likely correlate with less regular sleep, possibly in a way that isn't corrected for by the limited shift work categories.
this one selected about 100k people from a dataset of around 500k. All from one country/region (UK)
furthermore they dont measure sleep but they estimate if someone was maybe asleep based data from an accelerometer. so they cannot measure what sleep state someone acheived or if they were actually really sleep or just u know staring at the ceiling in an existential crisis....
These two goals are kind of at odds with one another. We can only get insight into depth of sleep achieved if we bring you into a sleep clinic, but we can't do that for a significant sample size...
If others in the house prefer to sleep from 10-6 and you prefer to sleep from 12-6, but others start making noise a 6, your sleep quality in the last two hours is destroyed. Then over time, it just results in poor sleep regularity, as you cycle between exhaustion and trying to sleep according to your internal clock.
In the past few years I went from having relaxed 11AM daily meetings to rigid 8AM meetings, and my sleep has suffered immensely. But nothing else in my life has changed, so it wouldn't show up in my socioeconomic data.
like "garbage collection"
Like, John Carmack said that he NEVER burned out, never went into a dark corner (verbatim from his interview), and everyone agrees that he works like a machine. And I don't think he actually spent a lot of mental training to achieve that stability, because, he has been like that from a young age. This is THE best thing you can have in the world, if you want to achieve something, anything. If you don't have the mental toughness, you won't be able to make through that 10,000 hours (cliche, I know). I guess that's also why many self-help book talk about being consistent -- to be consistent, is to have mental stability. And I think there is a whole difference, between someone who trains his mental to stay stable for 6 months, then collapse, from someone who actually doesn't need to train and just be stable somehow.
This also leads me to realize that good sleep is one of the fundamentals of a stable mind. As a parent, I actually don't remember when was the last time I had a good sleep, and my definition of a night of good sleep is perhaps just trivial for someone else. At the same time, I consider myself lucky, because at least I don't suffer from serious mental issues. I still have a job and a house, and that's better than many out there.
This then leads me to despise the human body. It is a machine so delicate that you have to be very lucky to be super productive, whatever your definition of being productive is. It seems to ignore the input in short term (e.g. you can eat garbage food for a month and nothing really happens, or, you can sleep 4-6 hours every day for the last 6 years and still function normally), but once the long term shows up it is very hard to reverse. And there are so many theories focused on it that we have no idea which one is best for the individual. You might as well spend years doing A/B test on yourself and still have no idea what the hell is going on. Or you need to be super rich to have some medical team monitor you 7/24 to figure out what the hell is going on.
Believable is important because you have to internally 100% without a doubt believe that what you're doing is the right thing to be doing now.
As soon as the "what ifs" starts to creep in for the big picture items or goals, that can destroy everything. I'm not talking about running into a technical implementation problems along the way (those can be fun), it's more like "did I pick the right language for this?" level of questions that sit in the back of your mind.
Personally when I find something to work on that I like and will have what I think is a favorable outcome, it's easy to put in 8-10 real 100% laser focused hours into a task every day, even if it spans weeks or months. I'd like to think most people can do this too, the hard part (for me at least) is having these things to work on.
I try to turn what-ifs into actions. Instead of a what if rumination it is a small task, or a small trial of something, or a move in general forward rather than not. Not even remotely close to doing this well all the time, but I notice an overall boost in mood and productivity when I reorient my mint to progress rather searching in the uncertainty space.
ADHD, for example, is correlated with both sleep cycle issues and worse outcomes in life (including higher rates of crime and participation in risky activities).
[1] https://www.impulsearc.com/wavelength/
[2] e.g. https://www.nature.com/articles/s41540-023-00300-w
I have seen many doctors, including sleep specialists, regarding insomnia. They all pointed to one source as the reason for the sleep issues: stress. And they all wanted to put me on prescription sleeping pills. I said no to that. Sleeping pills can cause dependence, and they often treat the symptom rather than the underlying cause. As a software developer, I am used to finding and fixing the underlying problem instead of relying on the quick fixes these doctors were offering me.
After much research, I figured out what I believe was the underlying problem, and the fix for it. The underlying problem was magnesium deficiency. As a software developer, I spend much of the day doing mentally demanding work. This is the kind of stress the doctors were talking about. Stress can increase the body's demand for magnesium and may contribute to low magnesium levels.
The cells in our body depend on minerals such as calcium and magnesium for normal function. Calcium plays an important role in activating muscles and nerve cells, while magnesium helps regulate calcium activity and supports relaxation of muscles and the nervous system. When you are low on magnesium, your muscles may remain tense and your nervous system may have a harder time settling down. That can contribute to muscle stiffness and difficulty sleeping.
The solution, in my case, was magnesium supplements. They fixed my muscle stiffness issues and my sleep issues. A special form of magnesium called magnesium L-threonate may be especially helpful for the brain because it appears to raise brain magnesium levels more effectively than some other forms.
I also find sauna before bed is good. I have a bed chiller so I can crank up the sauna before bed and not sweat a lot. Generally if I sauna and take the aforementioned supplements I sleep well. Exercise also seems to help me out a lot. If I exercise during the day, and a 4-5 times that week in general, I tend to sleep well.
I dont have problems normally, just cant sleep in high altitude, 3000m is already showing mild effects. Guess what, I do/did quite a bit of mountaineering, its easy to get above 5000m in himalayas, highest I've been in tent attempting to sleep before summit push was 6000m on Aconcagua. Tried both Mg and melatonin up there over multiple nights, 0 improvements. I had highest O2 blood level measured in 5500m by doctor (mandatory there) from whole group.
Physical effort makes better sleep for literally everybody, thats age old knowledge and I havent met a single exception yet.
I found gwern's take on Melatonin interesting: https://gwern.net/melatonin
A small excerpt:
> One might object that they do not wish to tamper with their natural sleep, even if melatonin is a normally-secreted hormone.
> Sad to say, I would point out to such readers that they are already profoundly tampering with their natural sleep cycle, and indeed, all of Western civilization is tampering with it; most of my readers do not even sleep multiple times during the day, as ‘Nature intends’ and as humans have usually slept through history, but rather in a single 7–9 hour long block.
> [...]
> Finally, there are multiple lines of research suggesting chronic sleep deprivation is prevalent among young adults (including historical comparisons). It is striking that unemployed adults sleep a full hour longer than the employed , and that when normal adults are placed in settings without artificial light like camping or without any time indicators, they sleep longer than before - exactly as if they were sleep deprived.
As someone who has never been a regular coffee consumer, I really didn't want to end up with the dual dependence of melatonin at night and then caffeine in the morning.
This thread is stimulating me to want to get my magnesium checked, but barring that I've found the most effective sleep interventions are the basic ones: get some exercise earlier in the day, and don't do screens for the last few hours before bed.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9424753/
The usual suggestions from doctors for first line treatment are more mild medications that have drowsiness as a side effect, prescribed at low dose. I would actually prefer many of these low dose options over some of the high dose melatonin supplements. Melatonin is a hormone and taking it can throw off natural production
The reason diphenhydramine Is associated with a slight increase in dementia risk is the anticholinergic properties. This risk increase is from correlational studies on other medications with anticholinergic medicines being taken for many years by elderly people, so the risk of taking Benadryl occasionally is low to none.
The prescription alternatives like doxepin have the same antihistamine properties without the anticholinergic properties when used at the prescribed dose.
This is an example where people can get themselves into the wrong outcome by assuming anything their doctor prescribes is a last resort quick fix, but anything they can source by themself is safer and superior.
Tramadol is routinely prescribed long term where I live. I know someone with a massive bottle good for something like 6 to 12 months of daily use. (I don't know if that's a good thing but it is certainly a thing.)
> There are few to no side-effects to melatonin use in adults (there is uncertainty about the risks & benefits in children & adolescents28), and it is not addictive or habit-forming like caffeine is. The usual dose for a night is 0.5-3 mg and I take 1.5mg [29]; my dose is highly likely to be too high. High doses may well be responsible for why some people try melatonin and report that it does nothing or hurts them, since in one study, the best dose for old people was 10x smaller (0.1mg or 0.3mg) and for one blind person, 0.5mg [30 31 32] . Zhdanova et al 1996 found 0.3mg & 1.0mg to affect sleep onset similarly. A study of delayed-release melatonin found with their high dose of 4mg (but not 0.4mg) elevated melatonin levels 10 hours after bedtime ( Gooneratne et al 2011) - potentially interfering with waking time.
It is difficult to find doses as small as 1mg sublingual (dissolve under the tongue) in my area. Everyone is trying to sell you 5-30mg chewables. And, I expect everyone is buying them under the assumption that more is better. But, here it explicitly is not.
The way melatonin works well for me is to wait until I'm already settled into bed and should be asleep, but I'm not. Do a couple body scans to relax for real. Try to think about something mindless. Then if I'm still awake, pop 1mg under my tongue. I'll usually wake in the morning with half of it drooled on my pillow :P
It usually takes 15-30 minutes before I get noticeably drowsy, but I feel no more groggy the next day than if I slept sober.
But I don't think it does anyone any favors to oversell the idea that it has "few" or "no" side effects -- it has mild side effects, most commonly reported in the literature are daytime fatigue, headaches and GI symptoms, and also nightmares. Mild doesn't mean it isn't a nonstarter for some people.
It's also important to remember that there are major gaps in what we know about melatonin; notably the effects of chronic supplementation are not well-studied, but earlier final awakening has been documented and this is quite commonly reported in anecdata -- I can contribute a datapoint there, as can most people in my circles who have used it.
To be clear, melatonin is great and useful, but as someone with a rare lifelong chronic sleep disorder who is intimately familiar with this substance, I think it's most useful when we're clear on what we know, what we don't know, and what actually are the limitations on a substance.
Just because downing a bottle of it probably won't cause systemic organ failure or otherwise any kind of medical emergency in most people doesn't mean there aren't tradeoffs to consider when using it, especially if you are sleep-challenged
- a long uninterrupted night cycle and a short (20-60 mins) afternoon nap. Around 2pm. - a night cycle split into two halves. With a 1-2h break (maybe up to 3h) starting around midnight to 2am.
The former is still very common, and imho stretching the definition of multiple cycles. The latter is more historical (more common when there are long winter nights and no electricity).
Also making it a “Western” problem is kinda weird? There are other cultures where single cycle sleep has existed. Even hunter-gatherer groups with little to no contact with the west. And alternatively afternoon naps are still quite common is some western areas. I guess the main thing that prevent it would be the classic work day schedule.
I've always had insomnia since I was a kid and I just chalked it up to "being a night owl." As a teenager, I mostly solved this by living in a permanent fog during the week and "catching up" by sleeping in on the weekend. As an adult, I was suffering greatly from chronic sleep deprivation because adults (mostly) don't have much control over when they can wake up to start the day.
Around 10 years ago, I started taking 5mg melatonin. It's going to sound like I'm overselling it, but it changed my life. It _very reliably_ makes me sleepy 1-2 hours after I take it. If I forget to take it, I am fully awake until the wee hours of the morning. Is it important to note that (for me), after I take it, I have to engage in some passive activity like (calm, non-shouty) YouTube repair videos or reading. Also, the "window of sleepiness" is at most about 30 minutes and if I decide to power through it, I will come out the other side fully awake again. Melatonin does not "force" me to sleep, only highly encourages it.
I was skeptical of melatonin for the longest time. Generally, I rarely see much if any positive effect from supplements. But (for me!) this stuff really works. If anyone reading this is on the fence, I highly recommend giving it a try. (With the acknowledgement that it takes about a week to get into a solid sleep schedule if yours is currently disorganized.)
Oddly, it has the opposite effect as sleeping pills on me, it doesn't make me sleep more but I'm more rested when I wake up. It even happened a few times that I only slept 5 hours but still could focus well at work and bike intensively for an hour in the evening, without glycine that was impossible.
At 20 euro/kg I think I'll take it for the rest of my life, and it probably will add a few years to my life.
Hmmmmmmm
People sharing their experience doesnt immediately mean AI-generated advert
"Health" and more specifically the supplement industry is just a revolving door of fads. There's also survivorship bias, those who are obvious get banned quickly.
I think this is just what happens if you read a lot of supplement forums and listen to the supplement podcasts a lot: You start developing elevated beliefs about the supplements, disdainful beliefs about doctors, and think you’re making superior choices having done your own research. That last point is some times critical for the supplements working, because if you believe you’re taking something special after having cracked the mystery by listening to 50 hours of Huberman or Rhonda Patrick (as examples) then the placebo effect will supercharge the result. Having belief that you’ve solved the problem makes the effects much stronger, especially for cases like this where the underlying problem was already pointed out as being stress related.
For me, avoiding high histamine foods as well as histamine liberators had helped tremendously.
The theory:
Anti-histamines like Benadryl make you sleepy by blocking histamine.
Well, instead of blocking the histamine, get rid of it in the first place by avoiding histamine foods (for example aged or preserved meats).
The brain histamine in your neurons is primarily synthesized from an amino acid. The histamine levels in neurons are different than the levels in mast cells.
There are a lot of degrees of hand waving in your theory that don’t work.
Which type, if you don't mind my asking? And how long did it take before you felt the benefits? I took it for a month once (forget which type) an hour before bed and nothing changed.
Much more deep sleep with Glycinate, some folks don’t like it because they feel too groggy after waking.
Bro Science, HN Edition in one sentence. Nice.
I don't know what the hell I was taking too much of, but I didn't have a good way to test it. I wish the body had some indicators.
The study that made this claim was performed by the person who patented magnesium L-threonate and sells it at a high price. They go after any company that tries to sell cheap generic versions. The study was in mice and only showed small increases.
Magnesium L-threonate doesn’t get absorbed into your body and go into your brain as a lot of the supplement podcasts and social media posts have been implying. Magnesium supplements like this dissociate into their components in your digestive tract. Magnesium and threonate get absorbed separately. So if magnesium L-threonate has some special properties, it would be because threonate does something to improve absorption or maybe has other effects in the body, but that’s a big if. Remember that the person claiming it works better has been making a lot of money off of that one study.
If you have the cash and don’t mind paying the price then there’s no reason to switch. Many people find that magnesium glycinate, which is cheap, works just as well if not better. Glycine supplementation has been found independently to improve sleep, so taking a magnesium supplement that dissociates into magnesium and glycinate might be helpful in its own way.
Magnesium builds up in the body. Some people are deficient and get strong effects from initially correcting the deficiency. Take high doses for too long and you can start accumulating enough to get into excessive magnesium range, which brings problems. That was previously a rare observation but it’s occurring more as people get into magnesium supplements from podcasts that encourage constant high dose protocols and repeat claims that everyone is severely deficient. Keep the dose moderate.
I tried magnesium before but didn’t see any effects after a week so threw in the towel. Then I read a comment by someone here that had the exact same symptoms as me (brain wouldn’t turn off), explained the underlying cause, suggested L-threonate, and explained that it’s a long-term deficiency and might take some time to build up sufficient reserves.
I have had insomnia my entire life, since I was a child. I would go to bed around midnight and fall asleep at 3am, if I was lucky. I simply could not get my brain to disengage.
Within a month of supplementation, I thought I noticed a bit of improvement. By two months, my insomnia was gone. Not better. Gone. I fall asleep within minutes now.
As a software developer, I am a much better doctor than actual trained doctors, and am definitely immune to any placebo effects.
Do you know they’re wrong? Please don’t invoke Dunning Kruger like this, it’s cliché and also wrong to do. There’s no indicator for whatever it is Dunning & Kruger showed, you cannot know if it applies to a single person. Their main plot showed a positive correlation between confidence and competence. Their paper has problems, their methodology has been rightly questioned, and some attempts to reproduce have failed. Plus keep in mind that, ironically, for people who are intimately familiar with the debate over DK, using it to essentially name-call someone backfires and has the opposite of the intended effect, it makes the name caller look confidently ignorant.
Or is there a "maximum low level deficit" which you will never leave with just eating the right stuff?
(Like VitamineD deficit - it can get so low, that you cant fix it by "just going more into the sun")
Doing a quick search for magnesium-rich foods, it seems like it would take either an unsustainable focus on eating these foods to see results on a similar timeline or an extremely prolonged timeline to see similar results.
That said, I am not a doctor or nutritionist. But my instinct is that you can get so far in the hole with a lifetime of magnesium deficiency that supplementation is by far the most time- and lifestyle-efficient to digging yourself out. Whether or not switching to magnesium-rich foods can sustain you being at correct levels will end up depending on what the size of the deficit was in the first place, but is probably worth a try.
Same as with VitD, seems like - at some point, your level is just that low that you cant restore it by "just eating right", you need more firepower
I did it recently and found out basically all my b vitamins were in the toilet along with my vitamin D level. I started taking a b complex vitamin and D3 supplement and found immediate improvements to brain fog and exhaustion.
There are some horrifying case studies where people took like too much zinc, or copper, or some other thing for years and got really really messed up.
I'm skeptical that avoidance of "relying on the quick fixes" generalizes to software developers as a whole :)
Most magnesium doesn't cross the blood brain barrier, such as the one you tried.
Try magnesium threonate, which does.
- two pieces of fruit per day
- two portions of vegetables per day
- half an hour of outside sunshine per day
- twice per week exercise until you sweat
- no sleep during the day
- get out of bed every morning around the same time
- no processed food!
What I did :
- LSD (microdosing + a semi dose one year ago) did absolute wonders on my anxiety (which was what kept me energetic). I would then describe myself as having a general anxiety disorder and I now describe myself as chill af. It's amazing. I'm still stressed out by things but that's normal and not my default mode anymore.
- Prolonged-release melatonin keeps me asleep for the whole night
- Took the habit of reading in the bed. I'm so tired that most evenings, I have a really hard time to read 5-10 pages, I must fight to keep my eyes open.
Going for a walk can also rewire your brain, but doing so on LSD will probably rewire it more quickly. Whether that's good or bad depends on whether you do a good job with the rewiring. It comes down to how well you trust yourself.
Think of it like jet lag. If you travel to the other side of the world, you rapidly shift schedule in accordance with your habits (the timing of your meals, light exposure, activity, socializing etc), whether that be night or day. These inputs more than ever influence morning-ness or evening-ness qua chronotype, with the advent of limitless evening light and entertainment.
The cortisol spikes are what get me. I can drink or not drink, exercise or not exercise, take magnesium or not take magnesium. The brain wants to tell me at 630 or 7 all the things that can go wrong or todos, instead of letting me sleep til 8. Sometimes it's much earlier than that.
I also wake up at the slightest sound or movement. It's been like this since I was a child. I'm defective, and all the bro science Youtube videos with top 10 science -based 'hacks' don't solve the problem. Know what does? Anti anxiety medication, but doctors don't prescribe benzos anymore.
Some more discussion then: https://news.ycombinator.com/item?id=42022151
Do you think our ancestors slept exactly 8 hours a night from 10pm to 6am? No they slept when they wanted.
Yeah I pretty much do expect that (but more like 6 or 7). They were awake a few hours after sunset by fire light, then get up fairly early. I certainly don't imagine them napping during the day, when they could be working together to get food, unless it's a climate where it's too hot to do anything in the middle of the day.
Studies of modern hunter gatherers seem to back this up e.g. [1]
It's widely known that Victorians would have two sleeps over night, with a productive period in the middle, but this seems to be a misconception based on a passing remark in one court case. Even if true, this is a post-industrial society with unhealthily long working hours and I don't think we should be copying their sleep patterns.
[1] https://www.sciencedirect.com/science/article/pii/S096098221...
But to answer your question-- for me, washing my face helps a lot. I don't know why. Not that I nap all that often.
I get the study design is not causal and all, but this R^2 looks very underfit for a study that claims a stronger predictor?
Basically my doctor's biggest concern right now is making sure I don't die in my sleep because of something the device records that I and my wife never even know happened. Its a point of debate right now how much to disrupt my life with side-effects to do that.
[1] https://www.garmin.com/en-US/p/1650098/
This has been game changing and keeps me on a regular sleep routine.